Asset profile

fluticasone propionate

Small molecule

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Approvedregulatory verdict

Evidence outlook

Approved: Asthma

Regulatory approval supersedes design-level evidence grading; the trials behind approval are preserved below as the drug's evidence history.

track record: Partial signal

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Competitive landscape

80 competitors in this universe: 9 direct rivals (same mechanism and indication), 11 same-class, 60 same-indication.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
Fluticasone Propionate: this drugApprovedSmall moleculeGlucocorticoid receptor
Albuterol / Budesonide (Airsupra)ApprovedCombinationBeta-2 adrenergic receptor, Glucocorticoid receptor, Glucocorticoid receptor / Beta-2 adrenergic receptor
Beclomethasone (QVAR)ApprovedSmall moleculeGlucocorticoid receptor
Ciclesonide (Alvesco)ApprovedSmall moleculeGlucocorticoid receptor
Fluticasone FuroateApprovedSmall moleculeGlucocorticoid receptor
Fluticasone Furoate / Umeclidinium / Vilanterol (Trelegy Ellipta)ApprovedSmall moleculeMuscarinic acetylcholine receptor (M3), Beta-2 adrenergic receptor, Glucocorticoid receptor, Glucocorticoid receptor / Beta-2 adrenergic receptor / Muscarinic M3 receptor (ICS/LABA/LAMA triple combination)
Fluticasone Furoate / VilanterolApprovedSmall moleculeBeta-2 adrenergic receptor, Glucocorticoid receptor, Glucocorticoid receptor / Beta-2 adrenergic receptor
Fluticasone Propionate / Salmeterol (Advair HFA)ApprovedCombinationGlucocorticoid receptor, Beta-2 adrenergic receptor, Glucocorticoid receptor / Beta-2 adrenergic receptor
Lodotra (Rayos)Approved—Glucocorticoid receptor
Ciclesonide (XRP1526)Phase 3Small moleculeGlucocorticoid receptor
Budesonide (Entocort EC)Approved—Glucocorticoid receptor
Budesonide (Ortikos)Approved—Glucocorticoid receptor
Budesonide (targeted-Release) (TARPEYO / Nefecon)ApprovedSmall moleculeGlucocorticoid receptor
Budesonide (Uceris Rectal Foam)Approved—Glucocorticoid receptor
Budesonide MMX (Uceris)Approved—Glucocorticoid receptor
Halobetasol Propionate Foam (Lexette)ApprovedSmall moleculeGlucocorticoid receptor

…and 65 more. Research shows the complete landscape.

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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(9 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2026 (1)
October 2026 (1)
Phase 4HealthyActive not recruiting
Est. primary completion 2026-10-31 · NCT02476825 · CT.gov ↗
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2027 (6)
January 2027 (1)
Phase 2/3Skin Inflammation, Allergic Contact DermatitisActive not recruiting
Est. primary completion 2027-01-01 · NCT05535738 · CT.gov ↗
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May 2027 (1)
Phase 4Acute Wheezing Disorders in Infants Aged 0 to 24 MonthsNot yet recruiting
Est. primary completion 2027-05-31 · NCT07675252 · CT.gov ↗
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June 2027 (2)
Phase 2Eustachian Tube DysfunctionRecruiting
Est. primary completion 2027-06-30 · NCT05275686 · CT.gov ↗
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Phase 2Bronchiolitis Obliterans Syndrome, Bronchiolitis Obliterans, Lung Diseases, Chronic Graft Versus Host DiseaseRecruiting
Est. primary completion 2027-06-30 · NCT05922761 · CT.gov ↗
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September 2027 (1)
Phase 4AsthmaNot yet recruiting
Est. primary completion 2027-09 · NCT07664527 · CT.gov ↗
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December 2027 (1)
Phase 3Chronic CoughRecruiting
Est. primary completion 2027-12 · NCT07582549 · CT.gov ↗
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2028 (2)
August 2028 (1)
Phase 3Chronic Obstructive Pulmonary DiseaseNot yet recruiting
Est. primary completion 2028-08 · NCT06234345 · CT.gov ↗
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December 2028 (1)
Phase 3AsthmaRecruiting
Est. primary completion 2028-12-30 · NCT05776927 · CT.gov ↗
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See the full readout calendar ↗

All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 3 (67)
Phase 2/3 (6)
Phase 2 (37)
Phase 1 (38)
Phase 4 (67)
Early phase / not applicable (13)
Used as active comparator (37)
Studied as part of a combination product (40)
Appears in other studies (333)