Asset profile

CM512

Multispecific antibody

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Earlyevidence

Evidence outlook

Mid-stage studies underway, no completed readout

Phase 2 studies are registered but none has completed a readout, so no evidence signal is assigned yet. The first graded signal arrives with a completed confirmatory readout.

Also in development:Chronic Obstructive Pulmonary Disease · Phase 2

How the evidence outlook works ↗

Competitive landscape

104 competitors in this universe: 1 direct rival (same mechanism and indication), 1 same-class, 102 same-indication; 59 further along in development.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
CM512: this drugPhase 2Multispecific antibodyTSLP + IL-13
JNJ-95597528Phase 2UndisclosedTSLP + IL-13
LunsekimigPhase 3Antibody-derived scaffoldTSLP + IL-13
Abrocitinib (Cibinqo)ApprovedSmall moleculeJAK1
Aclidinium Bromide (Tudorza Pressair)ApprovedSmall moleculeMuscarinic acetylcholine receptor (M3)
Aclidinium Bromide / Formoterol Fumarate (Duaklir Pressair)ApprovedSmall moleculeMuscarinic acetylcholine receptor (M3), Beta-2 adrenergic receptor
Baricitinib (Olumiant)ApprovedSmall moleculeJAK, JAK1/2
Benralizumab (Fasenra)ApprovedMonoclonal antibodyIL-5 receptor alpha, IL-5 receptor alpha (IL-5Rα / CD125); Fc region additionally engages FcγRIIIa on NK cells (ADCC), IL-5 receptor alpha (IL5RA) on eosinophils/basophils
Budesonide / Glycopyrrolate / Formoterol Fumarate (Breztri Aerosphere)ApprovedSmall moleculeGlucocorticoid receptor; Muscarinic M3; Beta-2 adrenergic
Crisaborole (Eucrisa)ApprovedSmall moleculePDE4
DepemokimabApprovedMonoclonal antibodyIL-5
Difamilast (Moizerto / Adquey)ApprovedSmall moleculePDE4
Dupilumab (Dupixent)ApprovedMonoclonal antibodyIL-4R-alpha
Ensifentrine (Ohtuvayre)ApprovedSmall moleculePDE3/PDE4
Fluticasone Furoate / Umeclidinium / Vilanterol (Trelegy Ellipta)ApprovedSmall moleculeMuscarinic acetylcholine receptor (M3), Beta-2 adrenergic receptor, Glucocorticoid receptor, Glucocorticoid receptor / Beta-2 adrenergic receptor / Muscarinic M3 receptor (ICS/LABA/LAMA triple combination)
Glycopyrrolate / Formoterol Fumarate (Bevespi Aerosphere)ApprovedSmall moleculeMuscarinic acetylcholine receptor (M3), Beta-2 adrenergic receptor

…and 89 more. Research shows the complete landscape.

Research

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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(5 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2026 (1)
November 2026 (1)
Phase 2Chronic Spontaneous Urticaria (CSU)Recruiting
Est. primary completion 2026-11-02 · NCT07166211 · CT.gov ↗
What to watch
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2027 (2)
July 2027 (1)
Phase 2AsthmaRecruiting
Est. primary completion 2027-07-21 · NCT07011524 · CT.gov ↗
What to watch
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December 2027 (1)
Phase 2Atopic DermatitisRecruiting
Est. primary completion 2027-12 · NCT07230483 · CT.gov ↗
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2028 (2)
March 2028 (1)
Phase 2Chronic Obstructive Pulmonary DiseaseNot yet recruiting
Est. primary completion 2028-03-17 · NCT06980142 · CT.gov ↗
What to watch
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May 2028 (1)
Phase 2Chronic Rhinosinusitis With Nasal PolyposisNot yet recruiting
Est. primary completion 2028-05-31 · NCT07519577 · CT.gov ↗
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See the full readout calendar ↗

All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 2 (7)
Phase 1 (1)