Asset profile

Benralizumab · Fasenra

Monoclonal antibody

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Approvedregulatory verdict

Evidence outlook

Approved: Asthma

Regulatory approval supersedes design-level evidence grading; the trials behind approval are preserved below as the drug's evidence history.

track record: Reliable signal

Also in development:Chronic Obstructive Pulmonary Disease · Phase 3

How the evidence outlook works ↗

Competitive landscape

96 competitors in this universe: 0 direct rivals (same mechanism and indication), 0 same-class, 96 same-indication.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
Benralizumab (Fasenra): this drugApprovedMonoclonal antibodyIL-5 receptor alpha, IL-5 receptor alpha (IL5RA) on eosinophils/basophils, IL-5 receptor alpha (IL-5Rα / CD125); Fc region additionally engages FcγRIIIa on NK cells (ADCC)
Aclidinium Bromide (Tudorza Pressair)ApprovedSmall moleculeMuscarinic acetylcholine receptor (M3)
Aclidinium Bromide / Formoterol Fumarate (Duaklir Pressair)ApprovedSmall moleculeMuscarinic acetylcholine receptor (M3), Beta-2 adrenergic receptor
Albuterol (Armstrong Albuterol HFA)ApprovedSmall moleculeBeta-2 adrenergic receptor
Albuterol / Budesonide (Airsupra)ApprovedCombinationBeta-2 adrenergic receptor, Glucocorticoid receptor, Glucocorticoid receptor / Beta-2 adrenergic receptor
Albuterol HFA (Armstrong's)ApprovedSmall moleculeBeta-2 adrenergic receptor
Albuterol HFA (Proventil HFA)ApprovedSmall moleculeBeta-2 adrenergic receptor
Albuterol Sulfate (Armstrong)ApprovedSmall moleculeBeta-2 adrenergic receptor
Albuterol Sulfate (Provenetil-HFA)ApprovedSmall moleculeBeta-2 adrenergic receptor
AminophyllineApprovedSmall moleculePhosphodiesterase (multi-subtype)
Beclomethasone (QVAR)ApprovedSmall moleculeGlucocorticoid receptor
Beclomethasone Dipropionate / Formoterol Fumarate / GlycopyrrolateApprovedSmall moleculeGlucocorticoid receptor / Beta-2 adrenergic receptor / Muscarinic M3 receptor (ICS/LABA/LAMA triple combination)
Budesonide (Pulmicort)ApprovedSmall moleculeGlucocorticoid receptor agonist
Budesonide / Formoterol Fumarate (SYMBICORT)ApprovedCombinationGlucocorticoid receptor; Beta-2 adrenergic receptor
Budesonide / Glycopyrrolate / Formoterol Fumarate (Breztri Aerosphere)ApprovedSmall moleculeGlucocorticoid receptor; Muscarinic M3; Beta-2 adrenergic
Ciclesonide (Alvesco)ApprovedSmall moleculeGlucocorticoid receptor

…and 81 more. Research shows the complete landscape.

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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(9 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2026 (2)
October 2026 (1)
Phase 4AsthmaActive not recruiting
Est. primary completion 2026-10-19 · NCT03953300 · CT.gov ↗
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December 2026 (1)
Phase 3AsthmaActive not recruiting
Est. primary completion 2026-12-23 · NCT05692180 · CT.gov ↗
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2027 (2)
June 2027 (1)
Phase 4AsthmaRecruiting
Est. primary completion 2027-06-30 · NCT06385236 · CT.gov ↗
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September 2027 (1)
Phase 4AsthmaEnrolling by invitation
Est. primary completion 2027-09-01 · NCT07654842 · CT.gov ↗
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2028 (2)
February 2028 (1)
Phase 3Eosinophilic Granulomatosis With Polyangiitis (EGPA), Hypereosinophilia Syndrome (HES)Recruiting
Est. primary completion 2028-02-20 · NCT06512883 · CT.gov ↗
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November 2028 (1)
Phase 3AsthmaRecruiting
Est. primary completion 2028-11-03 · NCT06750289 · CT.gov ↗
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2029 (2)
January 2029 (1)
Phase 2DRESS SyndromeNot yet recruiting
Est. primary completion 2029-01-05 · NCT06734884 · CT.gov ↗
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December 2029 (1)
Phase 3AsthmaRecruiting
Est. primary completion 2029-12-27 · NCT07444567 · CT.gov ↗
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2034 (1)
September 2034 (1)
Early phase / not applicableRhinosinusitis Chronic, Nasal PolypsRecruiting
Est. primary completion 2034-09-02 · NCT06501807 · CT.gov ↗
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See the full readout calendar ↗

All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 3 (35)
Phase 2/3 (2)
Phase 2 (17)
Phase 1 (4)
Phase 4 (12)
Early phase / not applicable (3)
Used as active comparator (1)