Asset profile
bb21217
Cell therapy
Evidence outlook · program status
Discontinued (2022), in favor of a successor program
bb21217 was the second BCMA-directed CAR T candidate under the bluebird bio/2seventy bio collaboration with Bristol Myers Squibb. 2seventy's FY2022 10-K states that, after reviewing the Phase 1 CRB-402 data and in light of Abecma (ide-cel), 2seventy and BMS do not intend to pursue further development. The successor product named by the source is Abecma, so the program was superseded rather than failed outright. The trials below are preserved as the program's evidence history; no evidence signal is assigned to a program the sponsor has stopped.
How the evidence outlook works ↗
Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
92 competitors in this universe: 32 direct rivals (same mechanism and indication), 0 same-class, 60 same-indication; 77 further along in development.
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| Bb21217: this drug | Phase 1 | Cell therapy | BCMA | ||
| Belantamab Mafodotin | Approved | Antibody–drug conjugate | BCMA | ||
| Ciltacabtagene Autoleucel | Approved | Cell therapy | BCMA | ||
| Idecabtagene Vicleucel | Approved | Cell therapy | BCMA | ||
| Anitocabtagene Autoleucel | Phase 3 | Cell therapy | BCMA | ||
| Equecabtagene Autoleucel | Phase 3 | Cell therapy | BCMA | ||
| HRC0202 | Phase 2 | Cell therapy | BCMA | ||
| PHE885 | Phase 2 | Cell therapy | BCMA | ||
| AZD4045 | Phase 1/2 | Cell therapy | BCMA | ||
| BCMA CAR-NK (Hrain) | Phase 1/2 | Cell therapy | BCMA | ||
| BCMA CAR-NK (Shenzhen Pregene Biopharma) | Phase 1/2 | Cell therapy | BCMA | ||
| BCMA-CART (Bioray Laboratories) | Phase 1/2 | Cell therapy | BCMA | ||
| BCMA-Targeted Prime CAR-T Cells (Chongqing Precision Biotech) | Phase 1/2 | Cell therapy | BCMA | ||
| GSK2857914 | Phase 1/2 | Monoclonal antibody | BCMA | ||
| Pamlectabart Tismanitin | Phase 1/2 | Adc (anti-bcma Antibody-targeted Amanitin Conjugate) | BCMA | ||
| SENL103 | Phase 1/2 | Cell therapy | BCMA |
…and 77 more. Research shows the complete landscape.
Unlock the full comparison
Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
Compare head-to-head
26 further head-to-head pairs are tracked; the rosters on each shared mechanism and indication page list every rival in the race.
Upcoming events
No upcoming readouts on record for this asset.
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.