Asset profile

Motixafortide

Peptide

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Approvedregulatory verdict

Evidence outlook

Approved: Multiple Myeloma

Regulatory approval supersedes design-level evidence grading; the trials behind approval are preserved below as the drug's evidence history.

track record: Weak signal

Also in development:Pancreatic Cancer · Phase 2

How the evidence outlook works ↗

Competitive landscape

66 competitors in this universe: 3 direct rivals (same mechanism and indication), 1 same-class, 62 same-indication.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
Motixafortide: this drugApprovedPeptideCXCR4
PlerixaforApprovedSmall moleculeCXCR4
Burixafor (TG-0054)Phase 2Small moleculeCXCR4
GPC-100Phase 2Small moleculeCXCR4
AD-214Phase 1Antibody-derived scaffoldCXCR4
Belantamab MafodotinApprovedAntibody–drug conjugateBCMA
BortezomibApprovedSmall moleculeProteasome
CarfilzomibApprovedSmall moleculeProteasome
Ciltacabtagene AutoleucelApprovedCell therapyBCMA
DaratumumabApprovedMonoclonal antibodyCD38
DenosumabApprovedMonoclonal antibodyRANKL
ElotuzumabApprovedMonoclonal antibodySLAMF7 (CS1/CD319)
ElranatamabApprovedMultispecific antibodyBCMA x CD3
Idecabtagene VicleucelApprovedCell therapyBCMA
IsatuximabApprovedMonoclonal antibodyCD38
IxazomibApprovedSmall moleculeProteasome

…and 51 more. Research shows the complete landscape.

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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(5 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2026 (1)
December 2026 (1)
Phase 4Multiple MyelomaRecruiting
Est. primary completion 2026-12-31 · NCT07101445 · CT.gov ↗
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2028 (3)
January 2028 (1)
Phase 1Sickle Cell DiseaseRecruiting
Est. primary completion 2028-01 · NCT06442761 · CT.gov ↗
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June 2028 (1)
Phase 2Pancreatic CancerActive not recruiting
Est. primary completion 2028-06 · NCT04543071 · CT.gov ↗
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August 2028 (1)
Phase 2Acute Myeloid Leukemia, Measurable Residual DiseaseRecruiting
Est. primary completion 2028-08-02 · NCT07392970 · CT.gov ↗
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2029 (1)
December 2029 (1)
Phase 1Sickle Cell DiseaseRecruiting
Est. primary completion 2029-12 · NCT06506461 · CT.gov ↗
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See the full readout calendar ↗

All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 3 (2)
Phase 2 (9)
Phase 1/2 (5)
Phase 1 (6)
Phase 4 (1)