Asset profile

Teclistamab

Multispecific antibody

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Approvedregulatory verdict

Evidence outlook

Approved: Multiple Myeloma

Regulatory approval supersedes design-level evidence grading; the trials behind approval are preserved below as the drug's evidence history.

Phase 2 portion's primary endpoint is overall response rate (shown); interim data cutoff April 2024, before study completion. Single-arm, no comparator.

track record: Weak signal

How the evidence outlook works ↗

Competitive landscape

71 competitors in this universe: 10 direct rivals (same mechanism and indication), 1 same-class, 60 same-indication.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
Teclistamab: this drugApprovedMultispecific antibodyBCMA x CD3
ElranatamabApprovedMultispecific antibodyBCMA x CD3
LinvoseltamabApprovedMultispecific antibodyBCMA x CD3
BCD-248Phase 3Multispecific antibodyBCMA x CD3
CM336Phase 3Multispecific antibodyBCMA x CD3
EtentamigPhase 3Multispecific antibodyBCMA x CD3
F182112Phase 3Multispecific antibodyBCMA x CD3
GR1803Phase 3Multispecific antibodyBCMA x CD3
TQB2934Phase 3Multispecific antibodyBCMA x CD3
YKST02Phase 2Multispecific antibodyBCMA x CD3
REGN5459Phase 1/2Multispecific antibodyBCMA x CD3
CizutamigPhase 1Multispecific antibodyBCMA x CD3
Belantamab MafodotinApprovedAntibody–drug conjugateBCMA
BortezomibApprovedSmall moleculeProteasome
CarfilzomibApprovedSmall moleculeProteasome
Ciltacabtagene AutoleucelApprovedCell therapyBCMA

…and 56 more. Research shows the complete landscape.

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Unlock the full comparison

Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Compare head-to-head

4 further head-to-head pairs are tracked; the rosters on each shared mechanism and indication page list every rival in the race.

Upcoming events

(39 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2026 (4)
November 2026 (2)
Phase 2Multiple MyelomaRecruiting
Est. primary completion 2026-11 · NCT06505369 · CT.gov ↗
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Phase 4Multiple MyelomaActive not recruiting
Est. primary completion 2026-11-03 · NCT07030517 · CT.gov ↗
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December 2026 (2)
Phase 1Multiple MyelomaRecruiting
Est. primary completion 2026-12-31 · NCT06465316 · CT.gov ↗
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Phase 2AL AmyloidosisRecruiting
Est. primary completion 2026-12-31 · NCT06935162 · CT.gov ↗
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2027 (10)
January 2027 (2)
Phase 2Severe Rapidly Progressive Interstitial Lung Disease Associated With Anti-MDA5Not yet recruiting
Est. primary completion 2027-01 · NCT07631208 · CT.gov ↗
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Phase 2AL AmyloidosisRecruiting
Est. primary completion 2027-01-31 · NCT07079423 · CT.gov ↗
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March 2027 (1)
Phase 1/2Multiple MyelomaRecruiting
Est. primary completion 2027-03-31 · NCT04068597 · CT.gov ↗
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April 2027 (1)
Phase 1Multiple MyelomaActive not recruiting
Est. primary completion 2027-04-07 · NCT04108195 · CT.gov ↗
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June 2027 (1)
Phase 2Multiple MyelomaActive not recruiting
Est. primary completion 2027-06 · NCT05572229 · CT.gov ↗
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August 2027 (1)
Phase 2Multiple MyelomaRecruiting
Est. primary completion 2027-08 · NCT05972135 · CT.gov ↗
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December 2027 (4)
Phase 2Multiple MyelomaRecruiting
Est. primary completion 2027-12 · NCT05231629 · CT.gov ↗
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Phase 1ABO Blood Type Incompatible Kidney TransplantationNot yet recruiting
Est. primary completion 2027-12-31 · NCT07706205 · CT.gov ↗
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Phase 1Recurrent Plasmablastic Lymphoma, Refractory Plasmablastic LymphomaRecruiting
Est. primary completion 2027-12-31 · NCT07332507 · CT.gov ↗
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Phase 2Multiple MyelomaRecruiting
Est. primary completion 2027-12-31 · NCT07657312 · CT.gov ↗
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2028 (8)
February 2028 (1)
Phase 2Multiple MyelomaRecruiting
Est. primary completion 2028-02-28 · NCT06948084 · CT.gov ↗
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April 2028 (2)
Phase 3Multiple MyelomaRecruiting
Est. primary completion 2028-04 · NCT05243797 · CT.gov ↗
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Phase 2Multiple MyelomaActive not recruiting
Est. primary completion 2028-04-26 · NCT06353022 · CT.gov ↗
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July 2028 (1)
Phase 2Multiple MyelomaRecruiting
Est. primary completion 2028-07-30 · NCT07638683 · CT.gov ↗
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August 2028 (1)
Phase 1Multiple MyelomaRecruiting
Est. primary completion 2028-08-08 · NCT07105059 · CT.gov ↗
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September 2028 (2)
Phase 2AL AmyloidosisActive not recruiting
Est. primary completion 2028-09 · NCT06649695 · CT.gov ↗
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Phase 2Multiple MyelomaRecruiting
Est. primary completion 2028-09-15 · NCT05695508 · CT.gov ↗
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December 2028 (1)
Phase 2Multiple MyelomaRecruiting
Est. primary completion 2028-12-31 · NCT06100237 · CT.gov ↗
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2029 (7)
January 2029 (1)
Phase 2Multiple MyelomaNot yet recruiting
Est. primary completion 2029-01-01 · NCT07757412 · CT.gov ↗
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March 2029 (1)
Phase 1/2Multiple MyelomaRecruiting
Est. primary completion 2029-03-31 · NCT07463807 · CT.gov ↗
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April 2029 (1)
Phase 2Multiple MyelomaRecruiting
Est. primary completion 2029-04 · NCT07107529 · CT.gov ↗
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June 2029 (1)
Phase 1Multiple MyelomaRecruiting
Est. primary completion 2029-06-01 · NCT07581704 · CT.gov ↗
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July 2029 (1)
Phase 2Multiple MyelomaActive not recruiting
Est. primary completion 2029-07-31 · NCT06171685 · CT.gov ↗
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August 2029 (1)
Phase 2Multiple MyelomaRecruiting
Est. primary completion 2029-08 · NCT06993675 · CT.gov ↗
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November 2029 (1)
Phase 2Multiple MyelomaNot yet recruiting
Est. primary completion 2029-11-01 · NCT06880601 · CT.gov ↗
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2030 (3)
April 2030 (1)
Phase 2Multiple MyelomaNot yet recruiting
Est. primary completion 2030-04-01 · NCT07029776 · CT.gov ↗
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July 2030 (1)
Phase 2Multiple MyelomaRecruiting
Est. primary completion 2030-07-31 · NCT05469893 · CT.gov ↗
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September 2030 (1)
Phase 2Multiple MyelomaActive not recruiting
Est. primary completion 2030-09-02 · NCT06577025 · CT.gov ↗
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2031 (4)
February 2031 (1)
Phase 3Multiple MyelomaNot yet recruiting
Est. primary completion 2031-02-14 · NCT07671287 · CT.gov ↗
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April 2031 (1)
Phase 3Multiple MyelomaRecruiting
Est. primary completion 2031-04-30 · NCT05552222 · CT.gov ↗
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June 2031 (1)
Phase 3Multiple MyelomaNot yet recruiting
Est. primary completion 2031-06 · NCT07740486 · CT.gov ↗
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October 2031 (1)
Phase 2Amyloid Light-chain AmyloidosisRecruiting
Est. primary completion 2031-10 · NCT07110844 · CT.gov ↗
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2032 (1)
November 2032 (1)
Phase 2Plasma Cell LeukemiaRecruiting
Est. primary completion 2032-11-06 · NCT07605416 · CT.gov ↗
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2033 (1)
June 2033 (1)
Phase 3Multiple MyelomaRecruiting
Est. primary completion 2033-06 · NCT07649525 · CT.gov ↗
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2036 (1)
December 2036 (1)
Phase 4Multiple MyelomaNot yet recruiting
Est. primary completion 2036-12 · NCT07474961 · CT.gov ↗
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See the full readout calendar ↗

All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 3 (8)
Phase 2 (29)
Phase 1/2 (4)
Phase 1 (11)
Phase 4 (3)
Early phase / not applicable (2)
Used as active comparator (3)
Appears in other studies (1)