Asset profile
Sintilimab
Monoclonal antibody
Evidence outlook · results not reported
ORIENT-3 (NCT03150875) · Non-small Cell Lung Cancer
The lead study's design has limits that temper confidence (see the rationale below), and its results have not been reported. This tier describes the design, not an outcome.
ORIENT-3 (NCT03150875): The trial randomized 290 participants to sintilimab or active docetaxel control, with 145 versus 135 participants included in the reported overall-survival analysis, but treatment was open-label rather than blinded. Results were not posted at the time of grading; the key result shown was recorded subsequently from the registry record.
How the evidence outlook works ↗
Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
83 competitors in this universe: 22 direct rivals (same mechanism and indication), 1 same-class, 60 same-indication; 61 further along in development.
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| Sintilimab: this drug | Phase 3 | Monoclonal antibody | PD-1 | ||
| Cemiplimab | Approved | Monoclonal antibody | PD-1 | ||
| Nivolumab | Approved | Monoclonal antibody | PD-1 | ||
| Opdivo Qvantig | Approved | Monoclonal antibody | PD-1 | ||
| Pembrolizumab | Approved | Monoclonal antibody | PD-1 | ||
| Pembrolizumab Berahyaluronidase Alfa | Approved | Monoclonal antibody | PD-1 | ||
| Retifanlimab | Approved | Monoclonal antibody | PD-1 | ||
| Toripalimab | Approved | Monoclonal antibody | PD-1 | ||
| Abp 234 | Phase 3 | Monoclonal antibody | PD-1 | ||
| Balstilimab | Phase 3 | Monoclonal antibody | PD-1 | ||
| Camrelizumab | Phase 3 | Monoclonal antibody | PD-1 | ||
| Cetrelimab | Phase 3 | Monoclonal antibody | PD-1 | ||
| CT-P51 | Phase 3 | Small molecule | PD-1 | ||
| Dostarlimab | Phase 3 | Monoclonal antibody | PD-1 | ||
| Enlonstobart | Phase 3 | Monoclonal antibody | PD-1 | ||
| MB12 | Phase 3 | Monoclonal antibody | PD-1 |
…and 68 more. Research shows the complete landscape.
Unlock the full comparison
Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
Compare head-to-head
16 further head-to-head pairs are tracked; the rosters on each shared mechanism and indication page list every rival in the race.
Upcoming events
(171 total)
Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.
2026 (27)
October 2026 (3)
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November 2026 (1)
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December 2026 (23)
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2027 (75)
January 2027 (1)
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February 2027 (1)
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March 2027 (4)
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April 2027 (7)
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May 2027 (6)
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June 2027 (9)
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July 2027 (9)
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August 2027 (2)
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September 2027 (6)
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October 2027 (6)
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November 2027 (2)
December 2027 (22)
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2028 (33)
January 2028 (2)
March 2028 (4)
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April 2028 (3)
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May 2028 (1)
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June 2028 (9)
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July 2028 (2)
August 2028 (1)
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September 2028 (3)
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October 2028 (2)
December 2028 (6)
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2029 (23)
January 2029 (2)
February 2029 (1)
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March 2029 (2)
April 2029 (2)
May 2029 (1)
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June 2029 (4)
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July 2029 (3)
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September 2029 (3)
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October 2029 (1)
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December 2029 (4)
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2030 (8)
January 2030 (1)
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April 2030 (1)
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May 2030 (2)
June 2030 (1)
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July 2030 (1)
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December 2030 (2)
2031 (3)
January 2031 (1)
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May 2031 (1)
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December 2031 (1)
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2033 (1)
June 2033 (1)
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2036 (1)
June 2036 (1)
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All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.