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Alectinib · Alecensa

Small molecule

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Approvedregulatory verdict

Evidence outlook

Approved: Non-Small Cell Lung Cancer (label: ALK-positive)

Regulatory approval supersedes design-level evidence grading; the trials behind approval are preserved below as the drug's evidence history.

track record: Partial signal

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Competitive landscape

65 competitors in this universe: 5 direct rivals (same mechanism and indication), 0 same-class, 60 same-indication.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
Alectinib (Alecensa): this drugApprovedSmall moleculeALK
BrigatinibApprovedSmall moleculeALK
CeritinibApprovedSmall moleculeALK
EnsartinibApprovedSmall moleculeALK
Neladalkib NVL-655Phase 3Small moleculeALK
AQUA07Phase 1Small moleculeALK
Afatinib (Gilotrif)ApprovedSmall moleculeEGFR/HER1, HER2, HER4
Alymsys (bevacizumab-Maly)ApprovedMonoclonal antibodyVEGF-A
AmivantamabApprovedMultispecific antibodyEGFR x c-MET
AtezolizumabApprovedMonoclonal antibodyPD-L1
BAT1706 (Avzivi)ApprovedMonoclonal antibodyVEGF-A
BAY2927088 (Hyrnuo)ApprovedSmall moleculeHER2 (ERBB2) exon 20 insertions and point mutations; also mutant-selective EGFR
BevacizumabApprovedMonoclonal antibodyVEGF-A, Vascular Endothelial Growth Factor Inhibitor
Bevacizumab-Awwb (MVASI)ApprovedMonoclonal antibodyVEGF-A
BinimetinibApprovedSmall moleculeMEK1/2
CapmatinibApprovedSmall moleculeMET

…and 50 more. Research shows the complete landscape.

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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(21 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2026 (5)
November 2026 (3)
Phase 2/3Non-Small Cell Lung CancerActive not recruiting
Est. primary completion 2026-11-18 · NCT05987956 · CT.gov ↗
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Phase 2Advanced Cancer, Solid Tumor, Haematological MalignancyRecruiting
Est. primary completion 2026-11-25 · NCT05159245 · CT.gov ↗
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Phase 2Non-Small Cell Lung CancerRecruiting
Est. primary completion 2026-11-30 · NCT04302025 · CT.gov ↗
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December 2026 (2)
Phase 1/2Non-Small Cell Lung CancerRecruiting
Est. primary completion 2026-12-01 · NCT05713006 · CT.gov ↗
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Phase 2Non-Small Cell Lung CancerRecruiting
Est. primary completion 2026-12-24 · NCT04322890 · CT.gov ↗
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2027 (3)
June 2027 (1)
Phase 2/3Non-Small Cell Lung CancerActive not recruiting
Est. primary completion 2027-06-30 · NCT03178552 · CT.gov ↗
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September 2027 (1)
Phase 2Cancer, Tumors, Neoplasm, NeoplasiaRecruiting
Est. primary completion 2027-09 · NCT02925234 · CT.gov ↗
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December 2027 (1)
Phase 2Rare TumourNot yet recruiting
Est. primary completion 2027-12-31 · NCT06692491 · CT.gov ↗
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2028 (2)
February 2028 (1)
Phase 1/2Non-Small Cell Lung CancerRecruiting
Est. primary completion 2028-02-28 · NCT05987644 · CT.gov ↗
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July 2028 (1)
Phase 3CancerActive not recruiting
Est. primary completion 2028-07-05 · NCT03768063 · CT.gov ↗
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2029 (6)
January 2029 (3)
Early phase / not applicableNon-Small Cell Lung CancerNot yet recruiting
Est. primary completion 2029-01 · NCT06709274 · CT.gov ↗
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Phase 1/2Non-Small Cell Lung CancerActive not recruiting
Est. primary completion 2029-01-01 · NCT03202940 · CT.gov ↗
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Phase 1/2Bone CancerNot yet recruiting
Est. primary completion 2029-01-15 · NCT07560410 · CT.gov ↗
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April 2029 (1)
Phase 2Cancer, Tumors, Neoplasms, NeoplasiaRecruiting
Est. primary completion 2029-04-30 · NCT04341181 · CT.gov ↗
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October 2029 (2)
Phase 2/3Haematological Malignancy, Malignant Neoplasm, Lymphoproliferative Disorders, Neoplasms by Histologic Type, Neoplasms by Site, Cancer …Recruiting
Est. primary completion 2029-10 · NCT05770037 · CT.gov ↗
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Phase 2/3Haematological Malignancy, Solid TumourRecruiting
Est. primary completion 2029-10 · NCT05722886 · CT.gov ↗
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2030 (1)
June 2030 (1)
Phase 3Non-Small Cell Lung CancerActive not recruiting
Est. primary completion 2030-06-16 · NCT05170204 · CT.gov ↗
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2031 (1)
August 2031 (1)
Phase 1Anaplastic Lymphoma Kinase, Anaplastic Large Cell LymphomaRecruiting
Est. primary completion 2031-08-08 · NCT07001384 · CT.gov ↗
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2032 (2)
February 2032 (1)
Phase 1/2ALK Fusion-positive Solid or CNS TumorsActive not recruiting
Est. primary completion 2032-02-28 · NCT04774718 · CT.gov ↗
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September 2032 (1)
Phase 2Solid TumorsActive not recruiting
Est. primary completion 2032-09-25 · NCT04589845 · CT.gov ↗
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2038 (1)
December 2038 (1)
Phase 2Metastatic Colorectal CancerRecruiting
Est. primary completion 2038-12-31 · NCT05725200 · CT.gov ↗
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See the full readout calendar ↗

All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 3 (8)
Phase 2/3 (4)
Phase 2 (24)
Phase 1/2 (10)
Phase 1 (10)
Phase 4 (1)
Early phase / not applicable (3)
Used as active comparator (2)
Appears in other studies (4)