Asset profile
pemetrexed · Alimta
Small molecule
Evidence outlook
Approved: Non-Small Cell Lung Cancer
Regulatory approval supersedes design-level evidence grading; the trials behind approval are preserved below as the drug's evidence history.
track record: Partial signal
How the evidence outlook works ↗
Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
60 competitors in this universe: 0 direct rivals (same mechanism and indication), 0 same-class, 60 same-indication.
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| Pemetrexed (Alimta): this drug | Approved | Small molecule | Thymidylate synthase (TS), dihydrofolate reductase (DHFR), GARFT, Thymidylate synthase (TS) | ||
| Afatinib (Gilotrif) | Approved | Small molecule | EGFR/HER1, HER2, HER4 | ||
| Alectinib (Alecensa) | Approved | Small molecule | ALK | ||
| Alymsys (bevacizumab-Maly) | Approved | Monoclonal antibody | VEGF-A | ||
| Amivantamab | Approved | Multispecific antibody | EGFR x c-MET | ||
| Atezolizumab | Approved | Monoclonal antibody | PD-L1 | ||
| BAT1706 (Avzivi) | Approved | Monoclonal antibody | VEGF-A | ||
| BAY2927088 (Hyrnuo) | Approved | Small molecule | HER2 (ERBB2) exon 20 insertions and point mutations; also mutant-selective EGFR | ||
| Bevacizumab | Approved | Monoclonal antibody | VEGF-A, Vascular Endothelial Growth Factor Inhibitor | ||
| Bevacizumab-Awwb (MVASI) | Approved | Monoclonal antibody | VEGF-A | ||
| Binimetinib | Approved | Small molecule | MEK1/2 | ||
| Brigatinib | Approved | Small molecule | ALK | ||
| Capmatinib | Approved | Small molecule | MET | ||
| Cemiplimab | Approved | Monoclonal antibody | PD-1 | ||
| Ceritinib | Approved | Small molecule | ALK | ||
| Crizotinib | Approved | Small molecule | ALK, ROS1, MET/HGFR, and RON |
…and 45 more. Research shows the complete landscape.
Unlock the full comparison
Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
Upcoming events
(187 total)
Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.
2026 (25)
October 2026 (4)
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November 2026 (3)
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December 2026 (18)
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2027 (64)
January 2027 (5)
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February 2027 (5)
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March 2027 (2)
April 2027 (4)
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May 2027 (5)
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June 2027 (10)
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July 2027 (3)
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August 2027 (5)
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September 2027 (5)
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October 2027 (7)
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November 2027 (7)
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December 2027 (6)
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2028 (36)
January 2028 (1)
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February 2028 (3)
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March 2028 (2)
April 2028 (4)
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May 2028 (6)
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June 2028 (1)
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July 2028 (2)
August 2028 (3)
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September 2028 (3)
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October 2028 (3)
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November 2028 (3)
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December 2028 (5)
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2029 (30)
January 2029 (4)
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February 2029 (3)
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March 2029 (3)
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April 2029 (4)
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May 2029 (5)
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June 2029 (2)
August 2029 (1)
September 2029 (3)
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October 2029 (1)
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November 2029 (2)
2030 (18)
January 2030 (4)
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February 2030 (1)
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April 2030 (1)
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May 2030 (3)
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June 2030 (1)
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July 2030 (3)
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September 2030 (1)
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November 2030 (2)
December 2030 (2)
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2031 (6)
January 2031 (1)
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April 2031 (1)
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August 2031 (1)
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October 2031 (2)
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December 2031 (1)
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2032 (4)
January 2032 (2)
2033 (2)
2035 (1)
December 2035 (1)
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2039 (1)
April 2039 (1)
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All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.