Mechanism
Thymidylate synthase (TS), dihydrofolate reductase (DHFR), GARFT
Assets acting on this target.
- Class
- Multi-targeted antifolate chemotherapy (pemetrexed)
- Pathway
- Inhibits folate-dependent enzymes required for de novo thymidine and purine nucleotide biosynthesis, blocking DNA replication
Research
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