Asset profile
Osimertinib · Tagrisso
Small molecule
Approvedregulatory verdict
Evidence outlook
Approved: Non-Small Cell Lung Cancer
Regulatory approval supersedes design-level evidence grading; the trials behind approval are preserved below as the drug's evidence history.
How the evidence outlook works ↗
Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
102 competitors in this universe: 41 direct rivals (same mechanism and indication), 1 same-class, 60 same-indication.
Unlock with Research ↗
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| Osimertinib (Tagrisso): this drug | Approved | Small molecule | EGFR | ||
| Gefitinib | Approved | Small molecule | EGFR | ||
| Lazertinib | Approved | Small molecule | EGFR | ||
| Sunvozertinib | Approved | Small molecule | EGFR | ||
| Alflutinib | Phase 3 | Small molecule | EGFR | ||
| Almonertinib | Phase 3 | Small molecule | EGFR | ||
| Befotertinib | Phase 3 | Small molecule | EGFR | ||
| BPI-7711 | Phase 3 | Small molecule | EGFR | ||
| CPO301 | Phase 3 | Antibody–drug conjugate | EGFR | ||
| FHND9041 | Phase 3 | Small molecule | EGFR | ||
| Icotinib | Phase 3 | Small molecule | EGFR | ||
| JMT101 | Phase 3 | Monoclonal antibody | EGFR | ||
| Limertinib | Phase 3 | Small molecule | EGFR, EGFR T790M (resistant mutant, selective over wild-type EGFR) | ||
| PLB1004 | Phase 3 | Small molecule | EGFR | ||
| SH-1028 | Phase 3 | Small molecule | EGFR | ||
| TY-9591 | Phase 3 | Small molecule | EGFR |
…and 87 more. Research shows the complete landscape.
Research
Unlock with Research ↗Unlock the full comparison
Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
Compare head-to-head
vs Gefitinib · Non-Small Cell Lung Cancervs Lazertinib · Non-Small Cell Lung Cancervs Almonertinib · Non-Small Cell Lung Cancervs BPI-7711 · Non-Small Cell Lung Cancervs Icotinib · Non-Small Cell Lung Cancervs SH-1028 · Non-Small Cell Lung Cancer
7 further head-to-head pairs are tracked; the rosters on each shared mechanism and indication page list every rival in the race.
Upcoming events
(91 total)
Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.
2026 (13)
November 2026 (2)
December 2026 (11)
Phase 1Non-Small Cell Lung CancerRecruiting
Est. primary completion 2026-12 · NCT07315113 · CT.gov ↗
What to watch
Phase 2Non-Small Cell Lung CancerActive not recruiting
Est. primary completion 2026-12 · NCT03909334 · CT.gov ↗
What to watch
Phase 1/2Metastatic Lung Non-Small Cell Carcinoma, Refractory Lung Non-Small Cell Carcinoma …Active not recruiting
Est. primary completion 2026-12-02 · NCT04285671 · CT.gov ↗
What to watch
Phase 3Non-Small Cell Lung CancerNot yet recruiting
Est. primary completion 2026-12-12 · NCT07376382 · CT.gov ↗
What to watch
Phase 2Non-Small Cell Lung CancerRecruiting
Est. primary completion 2026-12-24 · NCT04322890 · CT.gov ↗
What to watch
Phase 1Advanced Lung Non-Small Cell Carcinoma, Metastatic Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8 …Recruiting
Est. primary completion 2026-12-27 · NCT04762199 · CT.gov ↗
What to watch
Phase 1/2Non-Small Cell Lung CancerRecruiting
Est. primary completion 2026-12-30 · NCT06109558 · CT.gov ↗
What to watch
Phase 1Solid Tumor, AdultActive not recruiting
Est. primary completion 2026-12-31 · NCT06507306 · CT.gov ↗
What to watch
Phase 1Metastatic Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8, Stage IVB Lung Cancer AJCC v8Recruiting
Est. primary completion 2026-12-31 · NCT04780568 · CT.gov ↗
What to watch
Phase 2Non-Small Cell Lung CancerRecruiting
Est. primary completion 2026-12-31 · NCT07322783 · CT.gov ↗
What to watch
Phase 4Non-Small Cell Lung CancerActive not recruiting
Est. primary completion 2026-12-31 · NCT04413201 · CT.gov ↗
What to watch
2027 (35)
January 2027 (1)
Phase 1/2Non-Small Cell Lung CancerActive not recruiting
Est. primary completion 2027-01-31 · NCT04743505 · CT.gov ↗
What to watch
February 2027 (3)
Phase 2Lung Non-Small Cell CarcinomaRecruiting
Est. primary completion 2027-02-01 · NCT07323641 · CT.gov ↗
What to watch
Phase 3CancerActive not recruiting
Est. primary completion 2027-02-22 · NCT05629234 · CT.gov ↗
What to watch
Phase 1Metastatic Lung Non-Small Cell Carcinoma, Recurrent Lung Non-Small Cell Carcinoma, Stage III Lung Non-Small Cell Cancer AJCC v7 …Active not recruiting
Est. primary completion 2027-02-28 · NCT02503722 · CT.gov ↗
What to watch
March 2027 (1)
Phase 3Non-Small Cell Lung CancerNot yet recruiting
Est. primary completion 2027-03-26 · NCT06380348 · CT.gov ↗
What to watch
April 2027 (1)
Phase 2Lung Non-Small Cell Carcinoma, Recurrent Lung Non-Small Cell Carcinoma, Stage IIIB Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8 …Active not recruiting
Est. primary completion 2027-04-01 · NCT03410043 · CT.gov ↗
What to watch
May 2027 (2)
June 2027 (8)
Phase 1Lung CancerActive not recruiting
Est. primary completion 2027-06 · NCT03567642 · CT.gov ↗
What to watch
Phase 2Non-Small Cell Lung CancerRecruiting
Est. primary completion 2027-06 · NCT07485452 · CT.gov ↗
What to watch
Phase 1Non-Small Cell Lung CancerNot yet recruiting
Est. primary completion 2027-06-01 · NCT06557096 · CT.gov ↗
What to watch
Phase 1Metastatic Lung Non-Small Cell Carcinoma, Recurrent Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8Active not recruiting
Est. primary completion 2027-06-30 · NCT02496663 · CT.gov ↗
What to watch
Phase 1/2Solid TumorNot yet recruiting
Est. primary completion 2027-06-30 · NCT07612137 · CT.gov ↗
What to watch
Phase 2Recurrent Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8Recruiting
Est. primary completion 2027-06-30 · NCT05642572 · CT.gov ↗
What to watch
Phase 2Non-Small Cell Lung CancerActive not recruiting
Est. primary completion 2027-06-30 · NCT03392246 · CT.gov ↗
What to watch
Phase 2Advanced Lung Non-Small Cell Carcinoma, Recurrent Lung Non-Small Cell Carcinoma, Stage IIIB Lung Non-Small Cell Cancer AJCC v7 …Recruiting
Est. primary completion 2027-06-30 · NCT03191149 · CT.gov ↗
What to watch
July 2027 (2)
August 2027 (3)
Phase 3Non-Small Cell Lung CancerActive not recruiting
Est. primary completion 2027-08-02 · NCT05120349 · CT.gov ↗
What to watch
Phase 2Non-Small Cell Lung CancerRecruiting
Est. primary completion 2027-08-30 · NCT07669779 · CT.gov ↗
What to watch
Phase 2Non-Small Cell Lung CancerRecruiting
Est. primary completion 2027-08-31 · NCT07329322 · CT.gov ↗
What to watch
September 2027 (3)
Phase 2Lung AdenocarcinomaRecruiting
Est. primary completion 2027-09-01 · NCT05528458 · CT.gov ↗
What to watch
Phase 2Lung CancerRecruiting
Est. primary completion 2027-09-01 · NCT04591002 · CT.gov ↗
What to watch
Phase 2Non-Small Cell Lung CancerActive not recruiting
Est. primary completion 2027-09-30 · NCT03667820 · CT.gov ↗
What to watch
October 2027 (2)
Phase 2Non-Small Cell Lung CancerActive not recruiting
Est. primary completion 2027-10-01 · NCT05801029 · CT.gov ↗
What to watch
Phase 1Advanced Lung Non-Small Cell Carcinoma, Locally Advanced Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8 …Active not recruiting
Est. primary completion 2027-10-28 · NCT05166616 · CT.gov ↗
What to watch
November 2027 (1)
Phase 2Non-Small Cell Lung CancerNot yet recruiting
Est. primary completion 2027-11-30 · NCT06142617 · CT.gov ↗
What to watch
December 2027 (8)
Phase 2Non-Small Cell Lung CancerNot yet recruiting
Est. primary completion 2027-12 · NCT07038460 · CT.gov ↗
What to watch
Phase 2Non-Small Cell Lung CancerRecruiting
Est. primary completion 2027-12 · NCT06741085 · CT.gov ↗
What to watch
Phase 2Non-Small Cell Lung CancerNot yet recruiting
Est. primary completion 2027-12-12 · NCT06452433 · CT.gov ↗
What to watch
Phase 1/2Advanced Solid TumorRecruiting
Est. primary completion 2027-12-30 · NCT05785741 · CT.gov ↗
What to watch
Phase 2Non-Small Cell Lung CancerNot yet recruiting
Est. primary completion 2027-12-30 · NCT07603791 · CT.gov ↗
What to watch
Phase 2Non-Small Cell Lung CancerNot yet recruiting
Est. primary completion 2027-12-31 · NCT06918782 · CT.gov ↗
What to watch
Phase 2Rare TumourNot yet recruiting
Est. primary completion 2027-12-31 · NCT06692491 · CT.gov ↗
What to watch
Phase 2Advanced Lymphoma, Advanced Malignant Solid Neoplasm, Bladder Carcinoma, Breast Carcinoma, Cervical Carcinoma, Colon Carcinoma …Active not recruiting
Est. primary completion 2027-12-31 · NCT02465060 · CT.gov ↗
What to watch
2028 (20)
January 2028 (2)
February 2028 (3)
Phase 3Non-Small Cell Lung CancerRecruiting
Est. primary completion 2028-02-15 · NCT06829459 · CT.gov ↗
What to watch
Phase 2Non-Small Cell Lung CancerActive not recruiting
Est. primary completion 2028-02-28 · NCT03586453 · CT.gov ↗
What to watch
Phase 4Advanced Solid TumorsNot yet recruiting
Est. primary completion 2028-02-29 · NCT06824792 · CT.gov ↗
What to watch
March 2028 (2)
April 2028 (2)
May 2028 (1)
Phase 3Non-Small Cell Lung CancerActive not recruiting
Est. primary completion 2028-05-30 · NCT05009836 · CT.gov ↗
What to watch
June 2028 (1)
Phase 2Non-Small Cell Lung CancerRecruiting
Est. primary completion 2028-06-30 · NCT07375316 · CT.gov ↗
What to watch
September 2028 (1)
Phase 3Non-Small Cell Lung CancerRecruiting
Est. primary completion 2028-09 · NCT06486142 · CT.gov ↗
What to watch
October 2028 (4)
Phase 2Non-Small Cell Lung CancerNot yet recruiting
Est. primary completion 2028-10-01 · NCT07177092 · CT.gov ↗
What to watch
Phase 1/2Non-Small Cell Lung CancerRecruiting
Est. primary completion 2028-10-14 · NCT07206498 · CT.gov ↗
What to watch
Phase 1/2Non-Small Cell Lung CancerNot yet recruiting
Est. primary completion 2028-10-15 · NCT07486648 · CT.gov ↗
What to watch
Phase 3Non-Small Cell Lung CancerActive not recruiting
Est. primary completion 2028-10-31 · NCT03833154 · CT.gov ↗
What to watch
December 2028 (4)
Phase 2Advanced Solid TumorsRecruiting
Est. primary completion 2028-12 · NCT06895928 · CT.gov ↗
What to watch
Phase 3Non-Small Cell Lung CancerRecruiting
Est. primary completion 2028-12 · NCT06838273 · CT.gov ↗
What to watch
Phase 2Non-Small Cell Lung CancerRecruiting
Est. primary completion 2028-12-31 · NCT07622186 · CT.gov ↗
What to watch
Phase 2/3Non-Small Cell Lung CancerNot yet recruiting
Est. primary completion 2028-12-31 · NCT06908772 · CT.gov ↗
What to watch
2029 (11)
January 2029 (3)
Phase 2Non-Small Cell Lung CancerRecruiting
Est. primary completion 2029-01 · NCT06206850 · CT.gov ↗
What to watch
Early phase / not applicableNon-Small Cell Lung CancerNot yet recruiting
Est. primary completion 2029-01 · NCT06709274 · CT.gov ↗
What to watch
Phase 2Non-Small Cell Lung CancerRecruiting
Est. primary completion 2029-01-24 · NCT07058519 · CT.gov ↗
What to watch
April 2029 (1)
Phase 1/2Small Cell Lung Cancer ( SCLC ), Transformed Small Cell Lung CancerRecruiting
Est. primary completion 2029-04 · NCT07153055 · CT.gov ↗
What to watch
May 2029 (1)
Phase 2Lung CancerRecruiting
Est. primary completion 2029-05-30 · NCT07295821 · CT.gov ↗
What to watch
June 2029 (3)
Phase 2Non-Small Cell Lung CancerNot yet recruiting
Est. primary completion 2029-06 · NCT06436144 · CT.gov ↗
What to watch
Phase 2Non-Small Cell Lung CancerActive not recruiting
Est. primary completion 2029-06-30 · NCT05546866 · CT.gov ↗
What to watch
Phase 3Advanced Lung Non-Squamous Non-Small Cell Carcinoma, Metastatic Lung Non-Squamous Non-Small Cell Carcinoma …Recruiting
Est. primary completion 2029-06-30 · NCT04181060 · CT.gov ↗
What to watch
November 2029 (2)
December 2029 (1)
Phase 2Non-Small Cell Lung CancerNot yet recruiting
Est. primary completion 2029-12-31 · NCT07710612 · CT.gov ↗
What to watch
2030 (5)
February 2030 (1)
Phase 1Non-Small Cell Lung CancerRecruiting
Est. primary completion 2030-02 · NCT05142189 · CT.gov ↗
What to watch
May 2030 (1)
Phase 4Non-Small Cell Lung CancerRecruiting
Est. primary completion 2030-05-18 · NCT07279935 · CT.gov ↗
What to watch
June 2030 (1)
Phase 2Non-Small Cell Lung CancerRecruiting
Est. primary completion 2030-06-30 · NCT07073365 · CT.gov ↗
What to watch
September 2030 (1)
Phase 2/3Non-Small Cell Lung CancerRecruiting
Est. primary completion 2030-09 · NCT07155187 · CT.gov ↗
What to watch
December 2030 (1)
Phase 3Non-Small Cell Lung CancerRecruiting
Est. primary completion 2030-12 · NCT07640789 · CT.gov ↗
What to watch
2031 (6)
February 2031 (1)
Phase 1/2Lung Cancer, Breast CancerRecruiting
Est. primary completion 2031-02-26 · NCT06618287 · CT.gov ↗
What to watch
August 2031 (1)
Phase 3Non-Small Cell Lung CancerRecruiting
Est. primary completion 2031-08-01 · NCT07738172 · CT.gov ↗
What to watch
October 2031 (2)
Early phase / not applicableNon-Small Cell Lung CancerRecruiting
Est. primary completion 2031-10 · NCT06053099 · CT.gov ↗
What to watch
Phase 3Locally Advanced Lung Non-Small Cell Carcinoma, Stage IIB Lung Cancer AJCC v8, Stage III Lung Cancer AJCC v8Recruiting
Est. primary completion 2031-10-15 · NCT05624996 · CT.gov ↗
What to watch
2032 (1)
December 2032 (1)
Phase 2/3Non-Small Cell Lung CancerRecruiting
Est. primary completion 2032-12 · NCT07642024 · CT.gov ↗
What to watch
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.