Asset profile
Insulin Efsitora Alfa
Protein / enzyme therapeutic
Evidence outlook · lead readout
QWINT-1 (NCT05662332) · Type 2 Diabetes, T2D
The completed lead evidence is positive, with design limits that temper confidence; the rationale below says which.
QWINT-1 (NCT05662332): The trial was randomized and adequately sized, comparing efsitora with active-control insulin glargine in 795 participants, and its primary HbA1c endpoint met the prespecified noninferiority margin. However, the registry lists no participant or investigator masking, with only the sponsor blinded, so it does not have the fully double-blind design needed for the highest evidence grade.
How the evidence outlook works ↗
Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
80 competitors in this universe: 19 direct rivals (same mechanism and indication), 1 same-class, 60 same-indication; 33 further along in development.
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| Insulin Efsitora Alfa: this drug | Phase 3 | Protein / enzyme therapeutic | Insulin receptor (basal) | ||
| Afrezza | Approved | Peptide | Insulin receptor (basal), Insulin | ||
| Insulin Degludec (Tresiba) | Approved | Peptide | Insulin receptor (basal) | ||
| Insulin Detemir (Levemir) | Approved | Peptide | Insulin receptor (basal) | ||
| Insulin Glargine (Lantus / Toujeo) | Approved | Peptide | Insulin receptor (basal) | ||
| Insulin Glulisine (Apidra) | Approved | Peptide | Insulin receptor (basal) | ||
| Insulin Icodec (Awiqli) | Approved | Peptide | Insulin receptor (basal) | ||
| Insulin Lispro (Humalog) | Approved | Peptide | Insulin receptor (basal) | ||
| LY2963016 (Basaglar) | Approved | Peptide | Insulin receptor (basal) | ||
| LY900014 (Lyumjev) | Approved | Peptide | Insulin receptor (basal) | ||
| SAR341402 | Approved | Peptide | Insulin receptor (basal) | ||
| GZR33 | Phase 3 | Peptide | Insulin receptor (basal) | ||
| IcoSema (Kyinsu) | Phase 3 | Peptide | Insulin receptor (basal), GLP-1 receptor | ||
| INS068 | Phase 3 | Peptide | Insulin receptor (basal) | ||
| ORMD-0801 | Phase 3 | Peptide | Insulin receptor (basal) | ||
| THDB0206 | Phase 3 | Peptide | Insulin receptor (basal) |
…and 65 more. Research shows the complete landscape.
Unlock the full comparison
Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
Compare head-to-head
13 further head-to-head pairs are tracked; the rosters on each shared mechanism and indication page list every rival in the race.
Upcoming events
No upcoming readouts on record for this asset.
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.