Asset profile
metformin · Glucophage
Small molecule
Approvedregulatory verdict
Evidence outlook
Approved: Type 2 Diabetes
Regulatory approval supersedes design-level evidence grading; the trials behind approval are preserved below as the drug's evidence history.
track record: Reliable signal
Featured evidence outside covered markets:DPPOS (NCT00038727) · Diabetes Mellitus, Cancer, CVD · Phase 3 · mixed result · Partial signal
How the evidence outlook works ↗
Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
60 competitors in this universe: 0 direct rivals (same mechanism and indication), 0 same-class, 60 same-indication.
Unlock with Research ↗
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| Metformin (Glucophage): this drug | Approved | Small molecule | AMPK | ||
| Afrezza | Approved | Peptide | Insulin receptor (basal), Insulin | ||
| Alogliptin (Nesina) | Approved | Small molecule | DPP-4 | ||
| Bexagliflozin (Brenzavvy) | Approved | Small molecule | SGLT2 | ||
| Canagliflozin (Invokana) | Approved | Small molecule | SGLT2 | ||
| Dapagliflozin (Farxiga / Forxiga) | Approved | Small molecule | SGLT2 | ||
| Dulaglutide (Trulicity) | Approved | Peptide | GLP-1 receptor | ||
| Empagliflozin (Jardiance) | Approved | Small molecule | SGLT2 | ||
| Ertugliflozin (Steglatro) | Approved | Small molecule | SGLT2 | ||
| Glipizide (Glucotrol) | Approved | Small molecule | Sulfonylurea receptor (SUR1) | ||
| Glyburide (Diabeta / Micronase) | Approved | Small molecule | Sulfonylurea receptor (SUR1) | ||
| Insulin Aspart (NovoLog / Fiasp) | Approved | Peptide | Insulin receptor | ||
| Insulin Degludec (Tresiba) | Approved | Peptide | Insulin receptor (basal) | ||
| Insulin Detemir (Levemir) | Approved | Peptide | Insulin receptor (basal) | ||
| Insulin Glargine (Lantus / Toujeo) | Approved | Peptide | Insulin receptor (basal) | ||
| Insulin Glulisine (Apidra) | Approved | Peptide | Insulin receptor (basal) |
…and 45 more. Research shows the complete landscape.
Research
Unlock with Research ↗Unlock the full comparison
Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
Upcoming events
(132 total)
Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.
2026 (31)
October 2026 (4)
Phase 2/3Type 2 DiabetesActive not recruiting
Est. primary completion 2026-10-18 · NCT07033585 · CT.gov ↗
What to watch
Phase 1Type 2 DiabetesNot yet recruiting
Est. primary completion 2026-10-26 · NCT07511010 · CT.gov ↗
What to watch
Phase 4Type 2 DiabetesRecruiting
Est. primary completion 2026-10-30 · NCT07019012 · CT.gov ↗
What to watch
Phase 3Type 2 DiabetesActive not recruiting
Est. primary completion 2026-10-30 · NCT07026968 · CT.gov ↗
What to watch
November 2026 (7)
Phase 3Steinert's Disease, Myotonic Dystrophy 1, MetforminRecruiting
Est. primary completion 2026-11 · NCT05532813 · CT.gov ↗
What to watch
Phase 2Weight Loss, Gestational Diabetes Mellitus in Pregnancy, Postpartum CareRecruiting
Est. primary completion 2026-11 · NCT06948825 · CT.gov ↗
What to watch
Phase 1Muscle Atrophy, Insulin ResistanceActive not recruiting
Est. primary completion 2026-11-01 · NCT03107884 · CT.gov ↗
What to watch
Phase 2Type 1 Diabetes, ObesityRecruiting
Est. primary completion 2026-11-02 · NCT05414409 · CT.gov ↗
What to watch
Phase 1Healthy VolunteersRecruiting
Est. primary completion 2026-11-07 · NCT07446400 · CT.gov ↗
What to watch
Phase 3Osteo Arthritis KneeRecruiting
Est. primary completion 2026-11-20 · NCT06231758 · CT.gov ↗
What to watch
Phase 2/3Parkinson DiseaseRecruiting
Est. primary completion 2026-11-20 · NCT07229651 · CT.gov ↗
What to watch
December 2026 (20)
Early phase / not applicableType 2 DiabetesActive not recruiting
Est. primary completion 2026-12 · NCT02087826 · CT.gov ↗
What to watch
Phase 4Atrial FibrillationActive not recruiting
Est. primary completion 2026-12 · NCT03603912 · CT.gov ↗
What to watch
Phase 2Inflammatory Bowel DiseasesRecruiting
Est. primary completion 2026-12 · NCT05574387 · CT.gov ↗
What to watch
Phase 2Oesophageal Adenocarcinoma, Tumor MicroenvironmentRecruiting
Est. primary completion 2026-12 · NCT06687876 · CT.gov ↗
What to watch
Phase 3Type 2 DiabetesRecruiting
Est. primary completion 2026-12 · NCT07093476 · CT.gov ↗
What to watch
Phase 1Drug Drug Interaction (DDI); Pharmacokinetics and PharmacodynamicsRecruiting
Est. primary completion 2026-12 · NCT07785934 · CT.gov ↗
What to watch
Early phase / not applicableType 2 DiabetesEnrolling by invitation
Est. primary completion 2026-12-01 · NCT06846138 · CT.gov ↗
What to watch
Early phase / not applicableMelasma (Facial Melasma), MelasmaNot yet recruiting
Est. primary completion 2026-12-01 · NCT07485777 · CT.gov ↗
What to watch
Early phase / not applicableMelasmaNot yet recruiting
Est. primary completion 2026-12-01 · NCT07495748 · CT.gov ↗
What to watch
Phase 1Overweight, ObesityNot yet recruiting
Est. primary completion 2026-12-01 · NCT07502001 · CT.gov ↗
What to watch
Early phase / not applicablePolycystic Ovarian Syndrome (PCOS)Active not recruiting
Est. primary completion 2026-12-03 · NCT07604779 · CT.gov ↗
What to watch
Phase 1Overweight,ObesityRecruiting
Est. primary completion 2026-12-05 · NCT07550816 · CT.gov ↗
What to watch
Phase 1Advanced Pancreatic Cancer, Advanced Solid TumorActive not recruiting
Est. primary completion 2026-12-30 · NCT03889795 · CT.gov ↗
What to watch
Phase 1Breast Cancer, Solid TumorActive not recruiting
Est. primary completion 2026-12-31 · NCT03006172 · CT.gov ↗
What to watch
Phase 2Lung CarcinomaActive not recruiting
Est. primary completion 2026-12-31 · NCT04931017 · CT.gov ↗
What to watch
Early phase / not applicableMetformin, Prediabetes, In-Vitro FertilizationRecruiting
Est. primary completion 2026-12-31 · NCT06064669 · CT.gov ↗
What to watch
Phase 1Type 2 DiabetesRecruiting
Est. primary completion 2026-12-31 · NCT06120881 · CT.gov ↗
What to watch
Phase 4Type 2 DiabetesNot yet recruiting
Est. primary completion 2026-12-31 · NCT06762223 · CT.gov ↗
What to watch
Early phase / not applicablePolycystic Ovary Syndrome, Obesity, Infertility, FemaleNot yet recruiting
Est. primary completion 2026-12-31 · NCT06775093 · CT.gov ↗
What to watch
Phase 4Type 2 DiabetesNot yet recruiting
Est. primary completion 2026-12-31 · NCT07165158 · CT.gov ↗
What to watch
2027 (59)
January 2027 (5)
Phase 2Pelvic Pain, EndometriosisActive not recruiting
Est. primary completion 2027-01 · NCT06611501 · CT.gov ↗
What to watch
Phase 2Multiple SclerosisRecruiting
Est. primary completion 2027-01-01 · NCT06463743 · CT.gov ↗
What to watch
Phase 2Epidermal Melasma, Facial HyperpigmentationNot yet recruiting
Est. primary completion 2027-01-15 · NCT07779811 · CT.gov ↗
What to watch
Early phase / not applicableDefectRecruiting
Est. primary completion 2027-01-30 · NCT05205317 · CT.gov ↗
What to watch
February 2027 (5)
Early phase / not applicableStress Resilience, Blood-Brain Barrier Integrity, Mental HealthNot yet recruiting
Est. primary completion 2027-02 · NCT06965868 · CT.gov ↗
What to watch
Early phase / not applicableControlled Type 2 Diabetic Patients With PeriodontitisNot yet recruiting
Est. primary completion 2027-02-07 · NCT07753317 · CT.gov ↗
What to watch
Early phase / not applicableType 2 DiabetesRecruiting
Est. primary completion 2027-02-28 · NCT02969798 · CT.gov ↗
What to watch
Phase 3Intermittent ClaudicationRecruiting
Est. primary completion 2027-02-28 · NCT05132439 · CT.gov ↗
What to watch
Phase 2Multiple Sclerosis, Primary Progressive Multiple Sclerosis, Secondary-progressive Multiple SclerosisActive not recruiting
Est. primary completion 2027-02-28 · NCT05893225 · CT.gov ↗
What to watch
March 2027 (10)
Phase 1/2Multiple Sclerosis (MS)Recruiting
Est. primary completion 2027-03 · NCT04121468 · CT.gov ↗
What to watch
Phase 1TP53 Y220C Mutation, Advanced Solid TumorsRecruiting
Est. primary completion 2027-03 · NCT07372625 · CT.gov ↗
What to watch
Phase 1Type 1 Diabetes, Diabetic Kidney Disease, Cardiovascular Diseases, Endothelial Dysfunction, Insulin SensitivityRecruiting
Est. primary completion 2027-03-01 · NCT05065372 · CT.gov ↗
What to watch
Phase 4Intellectual Disability, Developmental Disability, ObesityRecruiting
Est. primary completion 2027-03-01 · NCT05744479 · CT.gov ↗
What to watch
Early phase / not applicableDental Implant, StabilityRecruiting
Est. primary completion 2027-03-09 · NCT07497568 · CT.gov ↗
What to watch
Phase 2Cirrhosis, Portal Hypertension Related to CirrhosisRecruiting
Est. primary completion 2027-03-30 · NCT06687265 · CT.gov ↗
What to watch
Phase 2Fibromyalgia SyndromeRecruiting
Est. primary completion 2027-03-31 · NCT05900466 · CT.gov ↗
What to watch
Phase 3Obesity and Cardiovascular Risk, Insulin Resistance, Obesity (Body Mass Index >30 kg/m2)Recruiting
Est. primary completion 2027-03-31 · NCT07297290 · CT.gov ↗
What to watch
Phase 4Type 2 DiabetesRecruiting
Est. primary completion 2027-03-31 · NCT07442006 · CT.gov ↗
What to watch
May 2027 (3)
Phase 2Malignant Brain NeoplasmRecruiting
Est. primary completion 2027-05-01 · NCT06377696 · CT.gov ↗
What to watch
Phase 2Alveolar CleftNot yet recruiting
Est. primary completion 2027-05-01 · NCT07536620 · CT.gov ↗
What to watch
Phase 1/2Prostate Cancer Recurrent, Solid Tumor, AdultRecruiting
Est. primary completion 2027-05-21 · NCT05036226 · CT.gov ↗
What to watch
June 2027 (5)
Early phase / not applicableGestational DiabetesRecruiting
Est. primary completion 2027-06 · NCT07645001 · CT.gov ↗
What to watch
Early phase / not applicableMales, Females, Sedentary, Metformin, PrediabetesRecruiting
Est. primary completion 2027-06-01 · NCT07131384 · CT.gov ↗
What to watch
Early phase / not applicableDepression, Depressive Disorder, Overweight or Obesity, Depressive SymptomsRecruiting
Est. primary completion 2027-06-11 · NCT07654179 · CT.gov ↗
What to watch
Phase 4Type 2 DiabetesNot yet recruiting
Est. primary completion 2027-06-30 · NCT07173712 · CT.gov ↗
What to watch
Phase 4Melasma (Facial Melasma)Enrolling by invitation
Est. primary completion 2027-06-30 · NCT07696806 · CT.gov ↗
What to watch
July 2027 (4)
Phase 2Osteosarcoma, Ewing SarcomaRecruiting
Est. primary completion 2027-07 · NCT04758000 · CT.gov ↗
What to watch
Phase 1Pre-Diabetes, Weight, Body, Cardiovascular DiseasesRecruiting
Est. primary completion 2027-07 · NCT06446531 · CT.gov ↗
What to watch
Phase 1Advanced Solid TumorRecruiting
Est. primary completion 2027-07-07 · NCT07098299 · CT.gov ↗
What to watch
Phase 2Oral LeukoplakiaRecruiting
Est. primary completion 2027-07-30 · NCT05727761 · CT.gov ↗
What to watch
August 2027 (2)
September 2027 (5)
Phase 2Oral LeukoplakiaRecruiting
Est. primary completion 2027-09 · NCT07387900 · CT.gov ↗
What to watch
Phase 2Type 2 DiabetesNot yet recruiting
Est. primary completion 2027-09-01 · NCT07139405 · CT.gov ↗
What to watch
Phase 3Type 1 Diabetes, Peripheral Arterial CalcificationActive not recruiting
Est. primary completion 2027-09-29 · NCT04583462 · CT.gov ↗
What to watch
Phase 2Infertility, FemaleNot yet recruiting
Est. primary completion 2027-09-30 · NCT06012682 · CT.gov ↗
What to watch
Phase 4Type 2 DiabetesNot yet recruiting
Est. primary completion 2027-09-30 · NCT07323381 · CT.gov ↗
What to watch
October 2027 (4)
Phase 4Plasminogen Activator Inhibitor-1 Deficiency, Cardiac FibrosisActive not recruiting
Est. primary completion 2027-10 · NCT05317806 · CT.gov ↗
What to watch
Phase 1Castration Sensitive Prostate CancerRecruiting
Est. primary completion 2027-10 · NCT06044025 · CT.gov ↗
What to watch
Early phase / not applicableType 2 DiabetesNot yet recruiting
Est. primary completion 2027-10-10 · NCT07778719 · CT.gov ↗
What to watch
Phase 4NIDDM, ObesityActive not recruiting
Est. primary completion 2027-10-30 · NCT05949008 · CT.gov ↗
What to watch
November 2027 (3)
Phase 1/2Focal Segmental GlomerulosclerosisRecruiting
Est. primary completion 2027-11 · NCT06090227 · CT.gov ↗
What to watch
Phase 3Medulloblastoma, Childhood, Cognitive ImpairmentRecruiting
Est. primary completion 2027-11-30 · NCT05230758 · CT.gov ↗
What to watch
December 2027 (13)
Phase 3Cognitive DeclineActive not recruiting
Est. primary completion 2027-12 · NCT04511416 · CT.gov ↗
What to watch
Phase 4Type 2 DiabetesNot yet recruiting
Est. primary completion 2027-12 · NCT06682351 · CT.gov ↗
What to watch
Phase 3Post COVID ConditionEnrolling by invitation
Est. primary completion 2027-12-01 · NCT07280572 · CT.gov ↗
What to watch
Phase 2Cystic Fibrosis-related Diabetes, Cystic FibrosisRecruiting
Est. primary completion 2027-12-30 · NCT04530383 · CT.gov ↗
What to watch
Phase 1Gestational DiabetesRecruiting
Est. primary completion 2027-12-31 · NCT05917587 · CT.gov ↗
What to watch
Phase 3PreeclampsiaRecruiting
Est. primary completion 2027-12-31 · NCT06033131 · CT.gov ↗
What to watch
Phase 3SchizophreniaRecruiting
Est. primary completion 2027-12-31 · NCT07045142 · CT.gov ↗
What to watch
Phase 3Polycystic Ovary Syndrome (PCOS)Not yet recruiting
Est. primary completion 2027-12-31 · NCT07120815 · CT.gov ↗
What to watch
Phase 4Type 2 DiabetesRecruiting
Est. primary completion 2027-12-31 · NCT07244003 · CT.gov ↗
What to watch
Early phase / not applicableLatent Autoimmune Diabetes in Adults (LADA)Not yet recruiting
Est. primary completion 2027-12-31 · NCT07460336 · CT.gov ↗
What to watch
Phase 4Type 2 DiabetesRecruiting
Est. primary completion 2027-12-31 · NCT07771010 · CT.gov ↗
What to watch
2028 (21)
January 2028 (2)
February 2028 (3)
Phase 2Appendiceal Mucinous Neoplasm, Pseudomyxoma PeritoneiRecruiting
Est. primary completion 2028-02 · NCT07693452 · CT.gov ↗
What to watch
Early phase / not applicableType 2 DiabetesNot yet recruiting
Est. primary completion 2028-02 · NCT07768280 · CT.gov ↗
What to watch
Phase 1/2ABCA4 Retinopathy, Stargardt Disease, Retinal Dystrophy, Retinal DegenerationActive not recruiting
Est. primary completion 2028-02-02 · NCT04545736 · CT.gov ↗
What to watch
March 2028 (1)
April 2028 (3)
Phase 3Pre-Eclampsia Onset Less Than 37 Weeks, Pre-Eclampsia, Pre-Eclampsia; Complicating Pregnancy, Pre-Eclampsia as Antepartum Condition …Not yet recruiting
Est. primary completion 2028-04 · NCT06452498 · CT.gov ↗
What to watch
Phase 1Osteoarthritis (OA) of the KneeRecruiting
Est. primary completion 2028-04-17 · NCT07065591 · CT.gov ↗
What to watch
Phase 2Posterior Fossa Ependymal TumorRecruiting
Est. primary completion 2028-04-30 · NCT07226453 · CT.gov ↗
What to watch
May 2028 (2)
Phase 2Glioblastoma, IDH-wildtypeRecruiting
Est. primary completion 2028-05 · NCT04945148 · CT.gov ↗
What to watch
Early phase / not applicableSafety and Impact of Medically Supervised Performance Enhancing Substance Usage in Healthy Elite AthletesEnrolling by invitation
Est. primary completion 2028-05-01 · NCT07568574 · CT.gov ↗
What to watch
June 2028 (2)
July 2028 (1)
Phase 1/2Heart Failure, Left Ventricular Assist DeviceRecruiting
Est. primary completion 2028-07 · NCT07666698 · CT.gov ↗
What to watch
August 2028 (1)
Phase 2Endometrial CancerRecruiting
Est. primary completion 2028-08-01 · NCT03675893 · CT.gov ↗
What to watch
September 2028 (2)
October 2028 (1)
Phase 2Sarcoma Metastatic, Sarcoma, Soft TissueRecruiting
Est. primary completion 2028-10 · NCT07291297 · CT.gov ↗
What to watch
November 2028 (1)
Phase 4Systemic Inflammation, Immune Dysregulation, Injection Drug Use, HIVRecruiting
Est. primary completion 2028-11-30 · NCT06829238 · CT.gov ↗
What to watch
2029 (8)
March 2029 (1)
Phase 3Idiopathic Pulmonary FibrosisNot yet recruiting
Est. primary completion 2029-03-15 · NCT07520110 · CT.gov ↗
What to watch
April 2029 (1)
Early phase / not applicableDiabete MellitusNot yet recruiting
Est. primary completion 2029-04-30 · NCT07589387 · CT.gov ↗
What to watch
May 2029 (3)
Phase 3COPDNot yet recruiting
Est. primary completion 2029-05-01 · NCT06999343 · CT.gov ↗
What to watch
Phase 4PCOS, Obesity, InfertilityRecruiting
Est. primary completion 2029-05-30 · NCT06742710 · CT.gov ↗
What to watch
Phase 1Muscle Atrophy or WeaknessRecruiting
Est. primary completion 2029-05-31 · NCT06185179 · CT.gov ↗
What to watch
June 2029 (1)
Phase 3Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8 …Recruiting
Est. primary completion 2029-06-16 · NCT06763328 · CT.gov ↗
What to watch
September 2029 (1)
Phase 4Prediabetic State, Atherosclerosis, MetforminRecruiting
Est. primary completion 2029-09-28 · NCT02915198 · CT.gov ↗
What to watch
December 2029 (1)
Phase 4Gestational Diabetes Mellitus, Pregnancy, High RiskRecruiting
Est. primary completion 2029-12 · NCT06445946 · CT.gov ↗
What to watch
2030 (5)
July 2030 (1)
Phase 1/2Breast Cancer, Solid Tumors, AdultRecruiting
Est. primary completion 2030-07 · NCT05768139 · CT.gov ↗
What to watch
September 2030 (2)
December 2030 (2)
Phase 2Breast Neoplasms, Breast Cancer, Breast Tumors, Angiosarcoma, TNBC - Triple-Negative Breast Cancer, HER2-positive Breast Cancer …Recruiting
Est. primary completion 2030-12 · NCT01042379 · CT.gov ↗
What to watch
Phase 3Autosomal Dominant Polycystic Kidney DiseaseRecruiting
Est. primary completion 2030-12 · NCT04939935 · CT.gov ↗
What to watch
2031 (5)
January 2031 (1)
Phase 3TuberculosisNot yet recruiting
Est. primary completion 2031-01 · NCT07136987 · CT.gov ↗
What to watch
March 2031 (2)
Phase 1/2Hyperemesis GravidarumRecruiting
Est. primary completion 2031-03 · NCT07129473 · CT.gov ↗
What to watch
Phase 3Alzheimer's Disease (AD), Mild Cognitive Impairment Due to Alzheimer's Disease, Alzheimer Disease DementiaRecruiting
Est. primary completion 2031-03 · NCT07724132 · CT.gov ↗
What to watch
October 2031 (1)
Phase 1Atrophy, Inflammation, Weakness, MuscleNot yet recruiting
Est. primary completion 2031-10-01 · NCT07699367 · CT.gov ↗
What to watch
November 2031 (1)
Phase 1/2Prostate CancerActive not recruiting
Est. primary completion 2031-11 · NCT04536805 · CT.gov ↗
What to watch
2032 (1)
April 2032 (1)
Phase 2Melanoma, NSCLC, Hepatocellular Carcinoma, Urothelial Cancer, Gastric Adenocarcinoma, HNSCC, Esophageal Adenocarcinoma …Recruiting
Est. primary completion 2032-04-30 · NCT04114136 · CT.gov ↗
What to watch
2035 (1)
October 2035 (1)
Phase 1Prostate CancerRecruiting
Est. primary completion 2035-10-20 · NCT05515978 · CT.gov ↗
What to watch
2043 (1)
December 2043 (1)
Phase 3Gestational Diabetes, Insulin ResistanceRecruiting
Est. primary completion 2043-12 · NCT02947503 · CT.gov ↗
What to watch
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.