Asset profile

Psilocybin (COMP360) · COMP360

Small molecule

Phase 3underway

Evidence outlook · registrational

Major Depressive Disorder: registrational readout pending

Its supporting mid-stage evidence has not yet been graded on this platform. Registrational readout expected around 2027-10-22.

How the evidence outlook works ↗

Upcoming events

(30 total)

Estimated primary-completion dates from ClinicalTrials.gov — registry estimates, never confirmed readout dates; they can move as trials progress.

2026 (3)
August 2026 (1)
Phase 1/2Depressive DisorderRecruiting
Est. primary completion 2026-08-20 · NCT06898606 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

December 2026 (2)
Phase 2Major Depressive DisorderRecruiting
Est. primary completion 2026-12 · NCT06319378 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 2Adjustment Disorder, Adjustment Disorder With Anxious Mood, Cancer, Cancer Cachexia, Cancer of Endometrium, Cancer of Kidney …Recruiting
Est. primary completion 2026-12-30 · NCT07072728 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

2027 (10)
January 2027 (1)
Phase 2Major Depressive DisorderRecruiting
Est. primary completion 2027-01-01 · NCT06782724 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

March 2027 (1)
Phase 2Major Depressive DisorderRecruiting
Est. primary completion 2027-03 · NCT06518720 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

April 2027 (2)
Phase 2Major Depressive DisorderRecruiting
Est. primary completion 2027-04 · NCT06512220 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 2Major Depressive DisorderActive not recruiting
Est. primary completion 2027-04-30 · NCT05947383 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

June 2027 (2)
Phase 2Parkinson Disease, DepressionRecruiting
Est. primary completion 2027-06 · NCT06455293 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 2Major Depressive DisorderRecruiting
Est. primary completion 2027-06-01 · NCT07183748 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

July 2027 (1)
Phase 2Major Depressive DisorderNot yet recruiting
Est. primary completion 2027-07 · NCT07479550 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

October 2027 (2)
Phase 3Major Depressive DisorderRecruiting
Est. primary completion 2027-10-22 · NCT07703722 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 2Lung Non-Small Cell Carcinoma, Unipolar DepressionRecruiting
Est. primary completion 2027-10-31 · NCT07216404 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

November 2027 (1)
Phase 1/2Major Depressive DiorderRecruiting
Est. primary completion 2027-11-30 · NCT07281352 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

2028 (9)
March 2028 (3)
Phase 2Major Depressive DisorderNot yet recruiting
Est. primary completion 2028-03 · NCT07405606 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 1/2Major Depressive DisorderRecruiting
Est. primary completion 2028-03-01 · NCT07251491 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 2Major Depressive DisorderRecruiting
Est. primary completion 2028-03-01 · NCT06592833 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

May 2028 (1)
Phase 2Major Depressive DisorderRecruiting
Est. primary completion 2028-05 · NCT06072898 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

June 2028 (1)
Phase 3Major Depressive DisorderRecruiting
Est. primary completion 2028-06-30 · NCT06247839 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

July 2028 (2)
Phase 2Major Depressive DisorderNot yet recruiting
Est. primary completion 2028-07 · NCT07373535 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 2Major Depressive DisorderRecruiting
Est. primary completion 2028-07 · NCT07211438 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

December 2028 (2)
Phase 2Major Depressive DisorderNot yet recruiting
Est. primary completion 2028-12 · NCT07566104 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 3Bipolar II DepressionNot yet recruiting
Est. primary completion 2028-12 · NCT06943573 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

2029 (4)
April 2029 (1)
Phase 2Methamphetamine Use Disorder, Human Immunodeficiency Virus (HIV)Not yet recruiting
Est. primary completion 2029-04 · NCT07756736 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

September 2029 (1)
Phase 2Major Depressive DisorderRecruiting
Est. primary completion 2029-09 · NCT07104916 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

December 2029 (2)
Phase 2Major Depressive DisorderRecruiting
Est. primary completion 2029-12-31 · NCT06132178 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 2Major Depressive DisorderNot yet recruiting
Est. primary completion 2029-12-31 · NCT07210112 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

2030 (3)
June 2030 (1)
Phase 2Major Depressive DisorderNot yet recruiting
Est. primary completion 2030-06-30 · NCT07745569 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

July 2030 (1)
Phase 2Depression, Parkinson's Disease (PD)Recruiting
Est. primary completion 2030-07 · NCT07610369 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

December 2030 (1)
Phase 3Major Depressive DisorderRecruiting
Est. primary completion 2030-12-02 · NCT07226232 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

2031 (1)
January 2031 (1)
Phase 1/2Major Depressive DisorderNot yet recruiting
Est. primary completion 2031-01-01 · NCT07499583 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

See the full readout calendar ↗

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