Asset profile
Esketamine · Spravato
Small molecule
Approvedregulatory verdict
Evidence outlook
Approved: Major Depressive Disorder
Regulatory approval supersedes design-level evidence grading; the trials behind approval are preserved below as the drug's evidence history.
track record: Reliable signal
How the evidence outlook works ↗
Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
67 competitors in this universe: 10 direct rivals (same mechanism and indication), 1 same-class, 56 same-indication.
Unlock with Research ↗
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| Esketamine (Spravato): this drug | Approved | Small molecule | NMDA receptor | ||
| AV-101 | Phase 3 | Small molecule | NMDA receptor | ||
| ACP-211 | Phase 2 | Small molecule | NMDA receptor | ||
| Arketamine (PRT042) | Phase 2 | Small molecule | NMDA receptor | ||
| BI 1569912 | Phase 2 | Small molecule | NMDA receptor | ||
| Blixeprodil | Phase 2 | Small molecule | NMDA receptor | ||
| CLE-100 | Phase 2 | Small molecule | NMDA receptor | ||
| Onfasprodil | Phase 2 | Small molecule | NMDA receptor | ||
| Zelquistinel | Phase 2 | Small molecule | NMDA receptor | ||
| ALA-3000 | Phase 1 | Small molecule | NMDA receptor | ||
| SP-101 | Phase 1 | Small molecule | NMDA receptor | ||
| Amantadine ER (Gocovri / ADS-5102) | Approved | Small molecule | NMDA receptor | ||
| Brexpiprazole (Rexulti) | Approved | Small molecule | Dopamine D2/D3 and serotonin 5-HT1A receptor | ||
| Cariprazine (Vraylar) | Approved | Small molecule | Dopamine D3/D2 receptor (partial agonist) | ||
| Cyclobenzaprine (Tonmya) | Approved | Small molecule | 5-HT2A, α1-adrenergic, H1-histaminergic, and M1-muscarinic acetylcholine receptors (functional antagonism) | ||
| Dextromethorphan / Bupropion (Auvelity) | Approved | Small molecule | sigma-1/NMDA |
…and 52 more. Research shows the complete landscape.
Research
Unlock with Research ↗Unlock the full comparison
Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
Compare head-to-head
vs AV-101 · Major Depressive Disordervs BI 1569912 · Major Depressive Disordervs Blixeprodil · Major Depressive Disordervs CLE-100 · Major Depressive Disordervs Onfasprodil · Major Depressive Disordervs Zelquistinel · Major Depressive Disorder
4 further head-to-head pairs are tracked; the rosters on each shared mechanism and indication page list every rival in the race.
Upcoming events
(54 total)
Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.
2026 (12)
October 2026 (1)
Early phase / not applicableBiliary and Pancreatic Diseases, Endoscopic Retrograde Cholangiopancreatography (ERCP)Not yet recruiting
Est. primary completion 2026-10-31 · NCT07584902 · CT.gov ↗
What to watch
November 2026 (3)
Phase 4Adults, Major Noncardiac Surgery, Dexmedetomidine, Esketamine, Postoperative Sleep DisturbancesRecruiting
Est. primary completion 2026-11 · NCT06859892 · CT.gov ↗
What to watch
Phase 1Esketamine, ECT, Depression, AdolescentRecruiting
Est. primary completion 2026-11-20 · NCT07247968 · CT.gov ↗
What to watch
Phase 4Depressed, Bariatric SurgeryActive not recruiting
Est. primary completion 2026-11-20 · NCT07179913 · CT.gov ↗
What to watch
December 2026 (8)
Phase 4Adverse Respiratory Events, Hypoxemia, Children, Gastroscopy, Esketamine, RemimazolamNot yet recruiting
Est. primary completion 2026-12 · NCT07748884 · CT.gov ↗
What to watch
Phase 4Elderly, Noncardiac Surgery, Delayed Neurocognitive Recovery, Postoperative Delirium, EsketamineNot yet recruiting
Est. primary completion 2026-12 · NCT07523334 · CT.gov ↗
What to watch
Phase 4Major Depressive DisorderRecruiting
Est. primary completion 2026-12-01 · NCT07369102 · CT.gov ↗
What to watch
Early phase / not applicableMajor Depressive DisorderRecruiting
Est. primary completion 2026-12-15 · NCT07422519 · CT.gov ↗
What to watch
Early phase / not applicableInsomnia, Breast Cancer Surgery, EsketamineRecruiting
Est. primary completion 2026-12-31 · NCT06773143 · CT.gov ↗
What to watch
Early phase / not applicablePost Induction HypotensionNot yet recruiting
Est. primary completion 2026-12-31 · NCT07374458 · CT.gov ↗
What to watch
Early phase / not applicableIrritable Bowel SyndromeRecruiting
Est. primary completion 2026-12-31 · NCT06788444 · CT.gov ↗
What to watch
Early phase / not applicableCircadian Rhythm, Postoperative Sleep DisturbanceRecruiting
Est. primary completion 2026-12-31 · NCT07315074 · CT.gov ↗
What to watch
2027 (24)
January 2027 (2)
Early phase / not applicablePerioperative Neurocognitive DisordersNot yet recruiting
Est. primary completion 2027-01-15 · NCT07665099 · CT.gov ↗
What to watch
Early phase / not applicableKnee Osteoarthritis, Replacement, Knee, Elective Surgical Patients, ASA Class I/II PatientsNot yet recruiting
Est. primary completion 2027-01-31 · NCT07736352 · CT.gov ↗
What to watch
February 2027 (3)
Phase 4Adenotonsillectomy, Children, Intranasal Administration, Dexmedetomidine, Esketamine, Postoperative PainRecruiting
Est. primary completion 2027-02 · NCT07479602 · CT.gov ↗
What to watch
Early phase / not applicableDepression, Anxiety, S-ketamine, Breast CancerNot yet recruiting
Est. primary completion 2027-02-01 · NCT07367542 · CT.gov ↗
What to watch
Early phase / not applicableAutism Spectrum DisorderRecruiting
Est. primary completion 2027-02-01 · NCT07324057 · CT.gov ↗
What to watch
March 2027 (2)
April 2027 (4)
Phase 4Major Depressive DisorderRecruiting
Est. primary completion 2027-04 · NCT06278779 · CT.gov ↗
What to watch
Phase 4Urinary Catheter, Catheter-related Bladder Discomfort, Dexmedetomidine, EsketamineRecruiting
Est. primary completion 2027-04 · NCT06399185 · CT.gov ↗
What to watch
Phase 4Spinal Surgery, Pain Intensity, Dexmedetomidine, Esketamine, Postoperative AnalgesiaNot yet recruiting
Est. primary completion 2027-04 · NCT07523321 · CT.gov ↗
What to watch
Early phase / not applicableCholestatic PruritusNot yet recruiting
Est. primary completion 2027-04-20 · NCT07760740 · CT.gov ↗
What to watch
May 2027 (3)
Early phase / not applicableThyroidectomy, Coughing ReflexNot yet recruiting
Est. primary completion 2027-05 · NCT07641673 · CT.gov ↗
What to watch
Early phase / not applicableThyroidectomy, Coughing ReflexNot yet recruiting
Est. primary completion 2027-05 · NCT07625826 · CT.gov ↗
What to watch
Early phase / not applicableIntrahepatic Cholestasis of PregnancyNot yet recruiting
Est. primary completion 2027-05-05 · NCT07560722 · CT.gov ↗
What to watch
June 2027 (4)
Early phase / not applicableDelirium in Old Age, Delirium, Postoperative, Anesthesia, Cognitive Dysfunction, Pain, Postoperative, Esketamine, Non-cardiac SurgeryRecruiting
Est. primary completion 2027-06 · NCT06817239 · CT.gov ↗
What to watch
Early phase / not applicableSenile PruritusNot yet recruiting
Est. primary completion 2027-06-20 · NCT07597486 · CT.gov ↗
What to watch
Early phase / not applicableDepth of Anesthesia Monitoring, BIS-EEGNot yet recruiting
Est. primary completion 2027-06-30 · NCT07699523 · CT.gov ↗
What to watch
Early phase / not applicableFibromyalgia, Pregabalin, EsketamineRecruiting
Est. primary completion 2027-06-30 · NCT07230171 · CT.gov ↗
What to watch
September 2027 (1)
Phase 2Out-of-hospital Cardiac Arrest (OHCA)Recruiting
Est. primary completion 2027-09-01 · NCT06744361 · CT.gov ↗
What to watch
November 2027 (3)
Phase 4Spinal Surgery, Pain Intensity, Dexmedetomidine, Esketamine, Postoperative AnalgesiaNot yet recruiting
Est. primary completion 2027-11 · NCT07525999 · CT.gov ↗
What to watch
Phase 4Older Adults, Cognitive Impairment, Sleep Disorders, Dexmedetomidine, EsketamineNot yet recruiting
Est. primary completion 2027-11 · NCT07610343 · CT.gov ↗
What to watch
Phase 4Behavior ProblemNot yet recruiting
Est. primary completion 2027-11-30 · NCT07570160 · CT.gov ↗
What to watch
2028 (10)
January 2028 (1)
Early phase / not applicableSuicidal IdeationEnrolling by invitation
Est. primary completion 2028-01 · NCT07396220 · CT.gov ↗
What to watch
March 2028 (1)
Early phase / not applicableBiliary Tract Diseases, Procedural Sedation and AnalgesiaNot yet recruiting
Est. primary completion 2028-03-10 · NCT07702240 · CT.gov ↗
What to watch
May 2028 (1)
Early phase / not applicableObesity, Pain, PostoperativeRecruiting
Est. primary completion 2028-05-31 · NCT03756961 · CT.gov ↗
What to watch
June 2028 (4)
Phase 1/2Intrauterine Polyp, Intrauterine SynechiaeActive not recruiting
Est. primary completion 2028-06-30 · NCT07034963 · CT.gov ↗
What to watch
Phase 1/2Hepatic Neoplasm, Hepatic CancerActive not recruiting
Est. primary completion 2028-06-30 · NCT07034950 · CT.gov ↗
What to watch
Phase 3Major Depressive DisorderRecruiting
Est. primary completion 2028-06-30 · NCT05973851 · CT.gov ↗
What to watch
Phase 3Major Depressive DisorderRecruiting
Est. primary completion 2028-06-30 · NCT05603104 · CT.gov ↗
What to watch
September 2028 (1)
Phase 4Subarachnoid Hemorrhage, Aneurysmal, Intracerebral Hemorrhage, Traumatic Brain InjuryRecruiting
Est. primary completion 2028-09-15 · NCT05095857 · CT.gov ↗
What to watch
2029 (5)
January 2029 (1)
Phase 4Dexmedetomidine, Ketamine, Analgesia, Respiratory Therapy, Intensive Care Units (ICUs), Agitation, Sedation and AnalgesiaNot yet recruiting
Est. primary completion 2029-01-01 · NCT07377981 · CT.gov ↗
What to watch
June 2029 (1)
Phase 4Older Patients, Surgery, Dexmedetomidine, Esketamine, Transcranial Direct Current Stimulation, Perioperative Neurocognitive DisordersNot yet recruiting
Est. primary completion 2029-06 · NCT07576517 · CT.gov ↗
What to watch
July 2029 (1)
Phase 4Ureteral Stricture, Dexmedetomidine, Esketamine, Depressive Symptoms, AnxietyNot yet recruiting
Est. primary completion 2029-07 · NCT07753772 · CT.gov ↗
What to watch
October 2029 (1)
Phase 4Parturients, Depressive Symptoms, Esketamine, Dexmedetomidine, Intranasal Administration, Postpartum DepressionNot yet recruiting
Est. primary completion 2029-10 · NCT07639099 · CT.gov ↗
What to watch
December 2029 (1)
Early phase / not applicableAged, Intensive Care Units, Ventilators, Mechanical, Dexmedetomidine, Esketamine, DeliriumNot yet recruiting
Est. primary completion 2029-12-01 · NCT06468436 · CT.gov ↗
What to watch
2030 (2)
June 2030 (1)
Phase 4Older Patients, Surgery, Dexmedetomidine, Esketamine, Transcranial Direct Current Stimulation, Cognitive Function, SurvivalNot yet recruiting
Est. primary completion 2030-06 · NCT07576543 · CT.gov ↗
What to watch
December 2030 (1)
2031 (1)
April 2031 (1)
Phase 3Major Depressive DisorderRecruiting
Est. primary completion 2031-04-09 · NCT07227454 · CT.gov ↗
What to watch
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.