Asset profile
ALTO-100
Small molecule
Evidence outlook · lead readout
NCT05712187 · Major Depressive Disorder
The completed lead evidence is positive, with design limits that temper confidence — see the rationale below for exactly which.
NCT05712187: The study was randomized, quadruple-blind, and placebo-controlled, with 301 participants, and used a clinical depression-symptom endpoint (MADRS). However, because the registry has no posted results, it is not possible to determine whether the primary endpoint was met.
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