Asset profile

Xanomeline/trospium chloride · Cobenfy

Small molecule

Approvedregulatory verdict

Evidence outlook

Approved — Schizophrenia

Regulatory approval supersedes design-level evidence grading — the trials behind approval are preserved below as the drug's evidence history.

track record: Reliable signal

Also in development:Alzheimer's Disease · Phase 3

How the evidence outlook works ↗

Upcoming events

(16 total)

Estimated primary-completion dates from ClinicalTrials.gov — registry estimates, never confirmed readout dates; they can move as trials progress.

2026 (3)
October 2026 (1)
Phase 3Alzheimer's DiseaseRecruiting
Est. primary completion 2026-10-05 · NCT05511363 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

November 2026 (1)
Phase 3Alzheimer's DiseaseRecruiting
Est. primary completion 2026-11-24 · NCT06585787 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

December 2026 (1)
Phase 3Alzheimer's DiseaseRecruiting
Est. primary completion 2026-12-09 · NCT06126224 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

2027 (2)
April 2027 (1)
Phase 1/2SchizophreniaRecruiting
Est. primary completion 2027-04-30 · NCT07423546 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

September 2027 (1)
Phase 3Alzheimer's DiseaseRecruiting
Est. primary completion 2027-09-07 · NCT05980949 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

2028 (6)
February 2028 (1)
Phase 3Alzheimer's DiseaseRecruiting
Est. primary completion 2028-02-21 · NCT06947941 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

September 2028 (3)
Phase 3Alzheimer's DiseaseRecruiting
Est. primary completion 2028-09-11 · NCT06976203 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 3Alzheimer's DiseaseRecruiting
Est. primary completion 2028-09-11 · NCT06976216 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 3SchizophreniaRecruiting
Est. primary completion 2028-09-23 · NCT06882785 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

November 2028 (2)
Phase 3Alzheimer's DiseaseRecruiting
Est. primary completion 2028-11-03 · NCT07011745 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 3Alzheimer's DiseaseRecruiting
Est. primary completion 2028-11-24 · NCT07011732 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

2029 (4)
January 2029 (1)
Phase 3SchizophreniaNot yet recruiting
Est. primary completion 2029-01-01 · NCT07084831 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

March 2029 (1)
Phase 3SchizophreniaNot yet recruiting
Est. primary completion 2029-03-03 · NCT07686263 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

June 2029 (1)
Phase 3Alzheimer's DiseaseRecruiting
Est. primary completion 2029-06-22 · NCT06937229 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

December 2029 (1)
Phase 3SchizophreniaRecruiting
Est. primary completion 2029-12-18 · NCT07288567 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

2030 (1)
March 2030 (1)
Phase 3SchizophreniaRecruiting
Est. primary completion 2030-03-08 · NCT07424404 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

See the full readout calendar ↗

All registered studies

Research

Unlock the complete ClinicalTrials.gov registry

Research includes every linked study, indication filters, phase grouping and featured-trial cross-links.

Competitive landscape

Research

Unlock the competitor landscape

Research compares assets by shared mechanism and indication, including each competitor's stage in the relevant market.