Asset profile
PM012
Botanical
Evidence outlook · registrational
Alzheimer's Disease: registrational readout pending
Entered Phase 3 on partial signal mid-stage evidence. The registry's posted readout date (2021-02-24) has passed without a status update. Check News for topline announcements.
ADD (NCT01715350): The study was randomized, quadruple-blind, placebo-controlled, and enrolled 151 participants, with a clinical cognitive primary endpoint (ADAS-cog). However, the primary comparison has no posted results, so whether it was met or missed is unknown.
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Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
65 competitors in this universe: 2 direct rivals (same mechanism and indication), 3 same-class, 60 same-indication; 23 further along in development.
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| PM012: this drug | Phase 2/3 | Botanical | Multi-target (ginsenoside) | ||
| Cerebrolysin | Phase 3 | Peptide | Multi-target (ginsenoside) | ||
| MLC901 (NeuroAiD II) | Phase 3 | Botanical | Multi-target (ginsenoside) | ||
| Shenfu Injection (Shenfu Zhusheye) | Phase 2/3 | Botanical | Multi-target (ginsenoside) | ||
| Jia Shen Tablet | Phase 2 | Botanical | Multi-target (ginsenoside) | ||
| QiShenYiQi | Phase 2 | Botanical | Multi-target (ginsenoside) | ||
| Benzgalantamine (Zunveyl) | Approved | Small molecule | Acetylcholinesterase/nicotinic receptor (prodrug) | ||
| Brexpiprazole (Rexulti) | Approved | Small molecule | Dopamine D2/D3 and serotonin 5-HT1A receptor | ||
| Dextromethorphan / Bupropion (Auvelity) | Approved | Small molecule | sigma-1/NMDA | ||
| Donanemab (Kisunla) | Approved | Monoclonal antibody | Amyloid-beta (monoclonal antibody) | ||
| Lecanemab (Leqembi) | Approved | Monoclonal antibody | Amyloid-beta (monoclonal antibody) | ||
| Xanomeline / Trospium Chloride (Cobenfy) | Approved | Small molecule | Muscarinic M1/M4 receptor (agonist/antagonist combination) | ||
| ACP-204 | Phase 3 | Small molecule | Serotonin 5-HT2A receptor (antagonist / inverse agonist) | ||
| AR1001 | Phase 3 | Small molecule | PDE5 | ||
| Bezisterim | Phase 3 | Small molecule | ERK/NF-kB inflammatory | ||
| Blarcamesine | Phase 3 | Small molecule | Sigma-1 receptor / muscarinic receptor (dual) |
…and 50 more. Research shows the complete landscape.
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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
Compare head-to-head
Upcoming events
No upcoming readouts on record for this asset.
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.