Head-to-head evidence
Mebufotenin (5-MeO-DMT) vs Psilocybin (COMP360)
Same mechanism, same race: design-graded trial evidence for both assets, with the grading rationale shown. Grades describe the quality of the evidence, never the merits of either security.
Major Depressive Disorder
Shared mechanism: 5-HT2A receptor · full Major Depressive Disorder pipeline
Mebufotenin (5-MeO-DMT) · GH001
Developed by GH Research
NCT05800860 · Phase 2 · completed
The study randomly assigned 81 participants and used quadruple blinding with a placebo comparator. Its primary endpoint was the change in MADRS depression scores from baseline to Day 7. Registry results were not posted at the time of grading; the key result shown was recovered from the cited external source.
Caveat: this result is taken from a company announcement or a news report of one, not from the trial registry or a peer-reviewed publication. Treat the figures as the sponsor's own statement, not as independently verified evidence.
Psilocybin (COMP360)
Developed by COMPASS Pathways
NCT05624268 · Phase 3 · completed
This was a randomized, quadruple-blind, placebo-controlled trial with 258 participants, using change in a standard clinician-rated depression scale as the primary measure. The sponsor reports a statistically significant difference favoring COMP360 over placebo at week 6.
Caveat: this result is taken from a company announcement or a news report of one, not from the trial registry or a peer-reviewed publication. Treat the figures as the sponsor's own statement, not as independently verified evidence.
Next expected readout: December 2026 · NCT06731621 (registry estimate)
The full competitive landscape for each asset (every same-race competitor with aligned evidence, sortable) is on the asset pages: Mebufotenin (5-MeO-DMT)'s landscape · Psilocybin (COMP360)'s landscape