Head-to-head evidence
Bretisilocin vs Psilocybin (COMP360)
Same mechanism, same race: design-graded trial evidence for both assets, with the grading rationale shown. Grades describe the quality of the evidence, never the merits of either security.
Major Depressive Disorder
Shared mechanism: 5-HT2A receptor · full Major Depressive Disorder pipeline
Bretisilocin
Developed by Gilgamesh Pharmaceuticals and partners
No graded featured trial for this indication yet; the grade above reflects that absence, not a judgment.
Psilocybin (COMP360)
Developed by COMPASS Pathways
NCT05624268 · Phase 3 · completed
This was a randomized, quadruple-blind, placebo-controlled trial with 258 participants, using change in a standard clinician-rated depression scale as the primary measure. The sponsor reports a statistically significant difference favoring COMP360 over placebo at week 6.
Caveat: this result is taken from a company announcement or a news report of one, not from the trial registry or a peer-reviewed publication. Treat the figures as the sponsor's own statement, not as independently verified evidence.
Next expected readout: December 2026 · NCT06731621 (registry estimate)
The full competitive landscape for each asset (every same-race competitor with aligned evidence, sortable) is on the asset pages: Bretisilocin's landscape · Psilocybin (COMP360)'s landscape