Asset profile

Dual-target Car-nk Cells

Cell therapy

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Earlyevidence

Evidence outlook

Early-stage evidence only

Phase 1 / first-in-human studies establish safety, tolerability, and dosing; they are not designed to demonstrate efficacy, so no evidence signal is assigned yet. The first graded signal arrives with a completed confirmatory readout.

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Competitive landscape

60 competitors in this universe: 0 direct rivals (same mechanism and indication), 0 same-class, 60 same-indication; 60 further along in development.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
Dual-Target Car-Nk Cells: this drugPhase 1/2Cell therapyDual-antigen combinations: MSLN+EGFR, MSLN+HER2/ERBB2
Afatinib (Gilotrif)ApprovedSmall moleculeEGFR/HER1, HER2, HER4
Alectinib (Alecensa)ApprovedSmall moleculeALK
Alymsys (bevacizumab-Maly)ApprovedMonoclonal antibodyVEGF-A
AmivantamabApprovedMultispecific antibodyEGFR x c-MET
AtezolizumabApprovedMonoclonal antibodyPD-L1
BAT1706 (Avzivi)ApprovedMonoclonal antibodyVEGF-A
BAY2927088 (Hyrnuo)ApprovedSmall moleculeHER2 (ERBB2) exon 20 insertions and point mutations; also mutant-selective EGFR
BevacizumabApprovedMonoclonal antibodyVEGF-A, Vascular Endothelial Growth Factor Inhibitor
Bevacizumab-Awwb (MVASI)ApprovedMonoclonal antibodyVEGF-A
BinimetinibApprovedSmall moleculeMEK1/2
BrigatinibApprovedSmall moleculeALK
CapmatinibApprovedSmall moleculeMET
CemiplimabApprovedMonoclonal antibodyPD-1
CeritinibApprovedSmall moleculeALK
CrizotinibApprovedSmall moleculeALK, ROS1, MET/HGFR, and RON

…and 45 more. Research shows the complete landscape.

Research

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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(10 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2027 (10)
February 2027 (3)
Phase 1/2Non-Small Cell Lung CancerRecruiting
Est. primary completion 2027-02-14 · NCT07467863 · CT.gov ↗
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Phase 1/2Breast Cancer (Locally Advanced or Metastatic), HER2-positive Breast Cancer, Triple-Negative Breast Cancer (TNBC)Recruiting
Est. primary completion 2027-02-14 · NCT07486089 · CT.gov ↗
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Phase 1Glioblastoma, High-grade Glioma, Malignant Glioma, Recurrent Glioblastoma, Recurrent High-grade GliomaRecruiting
Est. primary completion 2027-02-18 · NCT07480941 · CT.gov ↗
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March 2027 (5)
Phase 1/2Non-Small Cell Lung CancerRecruiting
Est. primary completion 2027-03-14 · NCT07641023 · CT.gov ↗
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Phase 1/2Breast Cancer (Advanced/Metastatic), HER2-positive Breast Cancer, Triple-negative Breast CancerRecruiting
Est. primary completion 2027-03-14 · NCT07510802 · CT.gov ↗
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Phase 1/2Advanced Hepatocellular Carcinoma (HCC), Metastatic Liver CancerRecruiting
Est. primary completion 2027-03-14 · NCT07500220 · CT.gov ↗
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Phase 1/2Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma, Biomarker-positive EGFR/HER2- Expressing HNSCCRecruiting
Est. primary completion 2027-03-14 · NCT07617805 · CT.gov ↗
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Phase 1/2Epithelial Ovarian Cancer, Epithelial Ovarian Cancer, Fallopian Tube or PeritoneumRecruiting
Est. primary completion 2027-03-14 · NCT07589543 · CT.gov ↗
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April 2027 (1)
Phase 1Malignant Glioma, High-Grade Gliomas, Glioblastoma, Recurrent High-Grade Gliomas, Recurrent GlioblastomaRecruiting
Est. primary completion 2027-04-14 · NCT07551336 · CT.gov ↗
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December 2027 (1)
Phase 1/2Colorectal Cancer Metastatic, Adenocarcinoma of ColonRecruiting
Est. primary completion 2027-12-21 · NCT07462650 · CT.gov ↗
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See the full readout calendar ↗

All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 1/2 (8)
Phase 1 (2)
Appears in other studies (5)