Asset profile

Levetiracetam (Keppra)

Small molecule

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Approvedregulatory verdict

Evidence outlook

Approved: Epilepsy

Regulatory approval supersedes design-level evidence grading; the trials behind approval are preserved below as the drug's evidence history.

track record: Partial signal

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Competitive landscape

60 competitors in this universe: 0 direct rivals (same mechanism and indication), 0 same-class, 60 same-indication.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
Levetiracetam (Keppra): this drugApprovedSmall moleculeSynaptic vesicle protein 2A (SV2A)
BrivaracetamApprovedSmall moleculeSynaptic vesicle glycoprotein 2A (SV2A)
Cannabidiol (Epidiolex)ApprovedSmall moleculeGPR55 / TRPV1 / adenosine transport (multi-target), cannabinoid
CarbamazepineApprovedSmall moleculeSodium channels
Cenobamate (Xcopri)ApprovedSmall moleculeSodium channels + GABA-A receptors
Clobazam (Onfi)ApprovedSmall moleculeGABA-A receptor
Clobazam (Sympazan)ApprovedSmall moleculeGABA-A receptor (benzodiazepine site)
DiastatApprovedCombinationGABA-A receptor
Diazepam (Valium)ApprovedSmall moleculeGABA-A receptor
Diazepam (Valtoco)ApprovedSmall moleculeGABA-A receptor
Divalproex Sodium (Depakote)ApprovedSmall moleculeGABAergic neurotransmission
Eslicarbazepine Acetate (Aptiom)ApprovedSmall moleculeVoltage-gated sodium channel
EthosuximideApprovedSmall moleculeT-type calcium channel
EverolimusApprovedSmall moleculemTOR kinase, mTOR (mTORC1) (inhibitor)
Ezogabine (Potiga)ApprovedSmall moleculeKv7 potassium channel
FelbamateApprovedSmall moleculeNMDA receptor (glycine site, antagonist)

…and 45 more. Research shows the complete landscape.

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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(19 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2027 (10)
January 2027 (2)
Phase 3EpilepsyRecruiting
Est. primary completion 2027-01 · NCT07239115 · CT.gov ↗
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Phase 2Splenomegaly, MyelofibrosisRecruiting
Est. primary completion 2027-01-01 · NCT06345495 · CT.gov ↗
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March 2027 (1)
Phase 4EpilepsyRecruiting
Est. primary completion 2027-03-15 · NCT07072624 · CT.gov ↗
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April 2027 (1)
Phase 4Traumatic Brain InjuryRecruiting
Est. primary completion 2027-04 · NCT06866691 · CT.gov ↗
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June 2027 (2)
Early phase / not applicableHematologic Disorders, Hemoglobinopathies, ImmunodeficienciesRecruiting
Est. primary completion 2027-06 · NCT01666080 · CT.gov ↗
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Phase 3Septic ShockNot yet recruiting
Est. primary completion 2027-06-15 · NCT06851078 · CT.gov ↗
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July 2027 (1)
Phase 2Neonatal Seizure, Neonatal Encephalopathy, Hypoxic-Ischemic Encephalopathy, Seizure NewbornRecruiting
Est. primary completion 2027-07-01 · NCT05610085 · CT.gov ↗
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November 2027 (1)
Phase 2Hematologic Malignancy, Acute Leukemia, Remission, Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, AML, TP53 …Recruiting
Est. primary completion 2027-11-30 · NCT05735717 · CT.gov ↗
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December 2027 (2)
Phase 2Hippocampal Hyperactivation, Prodromal Alzheimer DiseaseRecruiting
Est. primary completion 2027-12 · NCT07477431 · CT.gov ↗
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Phase 3EpilepsyRecruiting
Est. primary completion 2027-12 · NCT07234695 · CT.gov ↗
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2028 (3)
January 2028 (1)
Phase 4GliomaRecruiting
Est. primary completion 2028-01-01 · NCT03048084 · CT.gov ↗
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December 2028 (2)
Phase 3EpilepsyRecruiting
Est. primary completion 2028-12-30 · NCT07490769 · CT.gov ↗
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Phase 3Suspected StrokeRecruiting
Est. primary completion 2028-12-31 · NCT06773364 · CT.gov ↗
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2029 (3)
February 2029 (1)
Phase 2EpilepsyRecruiting
Est. primary completion 2029-02 · NCT07130786 · CT.gov ↗
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June 2029 (1)
Phase 3EpilepsyRecruiting
Est. primary completion 2029-06 · NCT06907173 · CT.gov ↗
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August 2029 (1)
Phase 2GlioblastomaNot yet recruiting
Est. primary completion 2029-08-01 · NCT07758062 · CT.gov ↗
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2030 (1)
April 2030 (1)
Phase 3Spontaneous Intracerebral HemorrhageNot yet recruiting
Est. primary completion 2030-04-02 · NCT07336992 · CT.gov ↗
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2031 (1)
June 2031 (1)
Phase 3EpilepsyRecruiting
Est. primary completion 2031-06-01 · NCT06442748 · CT.gov ↗
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2033 (1)
December 2033 (1)
Phase 3Severe Preeclampsia, Eclampsia PreeclampsiaNot yet recruiting
Est. primary completion 2033-12-31 · NCT07220902 · CT.gov ↗
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See the full readout calendar ↗

All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 3 (58)
Phase 2/3 (4)
Phase 2 (57)
Phase 1/2 (9)
Phase 1 (18)
Phase 4 (46)
Early phase / not applicable (33)
Used as active comparator (5)
Appears in other studies (6)