Asset profile
Clobazam (Onfi)
Small molecule
Evidence outlook
Approved: Epilepsy (label: adjunctive treatment of seizures associated with Lennox-Gastaut syndrome, age 2 and older)
Regulatory approval supersedes design-level evidence grading; the trials behind approval are preserved below as the drug's evidence history.
track record: Reliable signal
How the evidence outlook works ↗
Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
72 competitors in this universe: 9 direct rivals (same mechanism and indication), 3 same-class, 60 same-indication.
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| Clobazam (Onfi): this drug | Approved | Small molecule | GABA-A receptor | ||
| Diastat | Approved | Combination | GABA-A receptor | ||
| Diazepam (Valium) | Approved | Small molecule | GABA-A receptor | ||
| Diazepam (Valtoco) | Approved | Small molecule | GABA-A receptor | ||
| Ganaxolone | Approved | Small molecule | GABA-A receptor | ||
| Midazolam (Nayzilam) | Approved | Small molecule | GABA-A receptor, GABA-A receptor (benzodiazepine site) | ||
| Phenobarbital Sodium Injection (Sezaby) | Approved | Small molecule | GABA-A receptor | ||
| Stiripentol | Approved | Small molecule | GABA-A receptor | ||
| Diazepam (Libervant) | Phase 3 | Small molecule | GABA-A receptor | ||
| Staccato Alprazolam | Phase 3 | Combination | GABA-A receptor | ||
| KH607 | Phase 3 | Small molecule | GABA-A receptor | ||
| GlyphAllo (allopregnanolone Prodrug) (SPT-300) | Phase 2 | Small molecule | GABA-A receptor | ||
| HS-10353 | Phase 2 | Small molecule | GABA-A receptor | ||
| Brivaracetam | Approved | Small molecule | Synaptic vesicle glycoprotein 2A (SV2A) | ||
| Cannabidiol (Epidiolex) | Approved | Small molecule | GPR55 / TRPV1 / adenosine transport (multi-target), cannabinoid | ||
| Carbamazepine | Approved | Small molecule | Sodium channels |
…and 57 more. Research shows the complete landscape.
Unlock the full comparison
Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
Compare head-to-head
3 further head-to-head pairs are tracked; the rosters on each shared mechanism and indication page list every rival in the race.
Upcoming events
No upcoming readouts on record for this asset.
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.