Asset profile

Gabapentin

Small molecule

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Approvedregulatory verdict

Evidence outlook

Approved: Epilepsy

Regulatory approval supersedes design-level evidence grading; the trials behind approval are preserved below as the drug's evidence history.

track record: Partial signal

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Competitive landscape

61 competitors in this universe: 1 direct rival (same mechanism and indication), 0 same-class, 60 same-indication.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
Gabapentin: this drugApprovedSmall moleculeα2δ subunit of voltage-gated calcium channels
PregabalinApprovedSmall moleculeα2δ subunit of voltage-gated calcium channels
BrivaracetamApprovedSmall moleculeSynaptic vesicle glycoprotein 2A (SV2A)
Cannabidiol (Epidiolex)ApprovedSmall moleculeGPR55 / TRPV1 / adenosine transport (multi-target), cannabinoid
CarbamazepineApprovedSmall moleculeSodium channels
Cenobamate (Xcopri)ApprovedSmall moleculeSodium channels + GABA-A receptors
Clobazam (Onfi)ApprovedSmall moleculeGABA-A receptor
Clobazam (Sympazan)ApprovedSmall moleculeGABA-A receptor (benzodiazepine site)
DiastatApprovedCombinationGABA-A receptor
Diazepam (Valium)ApprovedSmall moleculeGABA-A receptor
Diazepam (Valtoco)ApprovedSmall moleculeGABA-A receptor
Divalproex Sodium (Depakote)ApprovedSmall moleculeGABAergic neurotransmission
Eslicarbazepine Acetate (Aptiom)ApprovedSmall moleculeVoltage-gated sodium channel
EthosuximideApprovedSmall moleculeT-type calcium channel
EverolimusApprovedSmall moleculemTOR kinase, mTOR (mTORC1) (inhibitor)
Ezogabine (Potiga)ApprovedSmall moleculeKv7 potassium channel

…and 46 more. Research shows the complete landscape.

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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

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Upcoming events

(12 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2026 (5)
October 2026 (1)
Early phase / not applicablePain Management, Analgesia, PostoperativeActive not recruiting
Est. primary completion 2026-10-25 · NCT07019103 · CT.gov ↗
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November 2026 (2)
Early phase / not applicableTheophylline, Sumatriptan, Gabapentin, Post-Dural Puncture HeadacheRecruiting
Est. primary completion 2026-11-01 · NCT07515456 · CT.gov ↗
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Phase 4Opioid Abuse (Disorder), Opioid Analgesia, Opioid Analgesic Adverse Reaction, Opioid ConsumptionEnrolling by invitation
Est. primary completion 2026-11-30 · NCT07750639 · CT.gov ↗
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December 2026 (2)
Phase 4Dental Pain and Sensation Disorder, Pain, PostoperativeRecruiting
Est. primary completion 2026-12 · NCT04860141 · CT.gov ↗
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Phase 2/3Pain, PostoperativeRecruiting
Est. primary completion 2026-12-31 · NCT04724252 · CT.gov ↗
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2027 (3)
October 2027 (1)
Phase 2/3Pain, Postoperative, Osteoarthritis, KneeNot yet recruiting
Est. primary completion 2027-10-30 · NCT07047040 · CT.gov ↗
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December 2027 (2)
Phase 4Breast CancerRecruiting
Est. primary completion 2027-12-16 · NCT07308717 · CT.gov ↗
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Phase 1Pain, Postoperative, Opioid UseActive not recruiting
Est. primary completion 2027-12-30 · NCT03498261 · CT.gov ↗
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2028 (2)
August 2028 (1)
Phase 3Alcohol Use DisorderRecruiting
Est. primary completion 2028-08-01 · NCT05827159 · CT.gov ↗
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December 2028 (1)
Phase 3Pediatric Chronic Neuropathic PainNot yet recruiting
Est. primary completion 2028-12 · NCT02219373 · CT.gov ↗
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2029 (1)
August 2029 (1)
Phase 3Head and Neck Squamous Cell Carcinoma, Stage I Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8 …Recruiting
Est. primary completion 2029-08-15 · NCT06992427 · CT.gov ↗
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2030 (1)
September 2030 (1)
Phase 4ACL Surgery, Pain ManagementRecruiting
Est. primary completion 2030-09 · NCT07158476 · CT.gov ↗
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See the full readout calendar ↗

All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 3 (72)
Phase 2/3 (19)
Phase 2 (55)
Phase 1/2 (7)
Phase 1 (37)
Phase 4 (115)
Early phase / not applicable (81)
Used as active comparator (18)
Studied as part of a combination product (1)
Appears in other studies (22)