Asset profile

Cenobamate · Xcopri

Small molecule

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Approvedregulatory verdict

Evidence outlook

Approved: Epilepsy

Regulatory approval supersedes design-level evidence grading; the trials behind approval are preserved below as the drug's evidence history.

track record: Reliable signal

How the evidence outlook works ↗

Competitive landscape

60 competitors in this universe: 0 direct rivals (same mechanism and indication), 0 same-class, 60 same-indication.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
Cenobamate (Xcopri): this drugApprovedSmall moleculeSodium channels + GABA-A receptors
BrivaracetamApprovedSmall moleculeSynaptic vesicle glycoprotein 2A (SV2A)
Cannabidiol (Epidiolex)ApprovedSmall moleculeGPR55 / TRPV1 / adenosine transport (multi-target), cannabinoid
CarbamazepineApprovedSmall moleculeSodium channels
Clobazam (Onfi)ApprovedSmall moleculeGABA-A receptor
Clobazam (Sympazan)ApprovedSmall moleculeGABA-A receptor (benzodiazepine site)
DiastatApprovedCombinationGABA-A receptor
Diazepam (Valium)ApprovedSmall moleculeGABA-A receptor
Diazepam (Valtoco)ApprovedSmall moleculeGABA-A receptor
Divalproex Sodium (Depakote)ApprovedSmall moleculeGABAergic neurotransmission
Eslicarbazepine Acetate (Aptiom)ApprovedSmall moleculeVoltage-gated sodium channel
EthosuximideApprovedSmall moleculeT-type calcium channel
EverolimusApprovedSmall moleculemTOR kinase, mTOR (mTORC1) (inhibitor)
Ezogabine (Potiga)ApprovedSmall moleculeKv7 potassium channel
FelbamateApprovedSmall moleculeNMDA receptor (glycine site, antagonist)
FenfluramineApprovedSmall moleculeSerotonin 5-HT2 receptors

…and 45 more. Research shows the complete landscape.

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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(6 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2026 (1)
November 2026 (1)
Phase 3EpilepsyActive not recruiting
Est. primary completion 2026-11 · NCT05067634 · CT.gov ↗
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2027 (3)
January 2027 (2)
Phase 2EpilepsyRecruiting
Est. primary completion 2027-01-31 · NCT06590896 · CT.gov ↗
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Phase 3EpilepsyRecruiting
Est. primary completion 2027-01-31 · NCT06579573 · CT.gov ↗
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May 2027 (1)
Phase 4Focal Onset SeizureActive not recruiting
Est. primary completion 2027-05-26 · NCT06453213 · CT.gov ↗
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2028 (2)
March 2028 (1)
Phase 3EpilepsyRecruiting
Est. primary completion 2028-03-30 · NCT07594158 · CT.gov ↗
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June 2028 (1)
Phase 1EpilepsyNot yet recruiting
Est. primary completion 2028-06 · NCT06352723 · CT.gov ↗
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See the full readout calendar ↗

All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 3 (7)
Phase 2 (4)
Phase 1 (7)
Phase 4 (1)