Asset profile

Huaier Granule

Protein / enzyme therapeutic

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Phase 3underway

Evidence outlook · registrational

Non-Small Cell Lung Cancer: registrational readout pending

Its supporting mid-stage evidence has not yet been graded on this platform. Registrational readout expected around 2028-06-30.

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Competitive landscape

62 competitors in this universe: 2 direct rivals (same mechanism and indication), 0 same-class, 60 same-indication; 58 further along in development.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
Huaier Granule: this drugPhase 3Protein / enzyme therapeuticN/A (innate, non-antigen-specific NK-cell cytotoxicity)
HankPhase 2Cell therapyN/A (innate, non-antigen-specific NK-cell cytotoxicity)
HS-IT101Phase 2Small moleculeN/A (innate, non-antigen-specific NK-cell cytotoxicity)
Afatinib (Gilotrif)ApprovedSmall moleculeEGFR/HER1, HER2, HER4
Alectinib (Alecensa)ApprovedSmall moleculeALK
Alymsys (bevacizumab-Maly)ApprovedMonoclonal antibodyVEGF-A
AmivantamabApprovedMultispecific antibodyEGFR x c-MET
AtezolizumabApprovedMonoclonal antibodyPD-L1
BAT1706 (Avzivi)ApprovedMonoclonal antibodyVEGF-A
BAY2927088 (Hyrnuo)ApprovedSmall moleculeHER2 (ERBB2) exon 20 insertions and point mutations; also mutant-selective EGFR
BevacizumabApprovedMonoclonal antibodyVEGF-A, Vascular Endothelial Growth Factor Inhibitor
Bevacizumab-Awwb (MVASI)ApprovedMonoclonal antibodyVEGF-A
BinimetinibApprovedSmall moleculeMEK1/2
BrigatinibApprovedSmall moleculeALK
CapmatinibApprovedSmall moleculeMET
CemiplimabApprovedMonoclonal antibodyPD-1

…and 47 more. Research shows the complete landscape.

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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(9 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2027 (6)
January 2027 (1)
Phase 4ProteinuriaNot yet recruiting
Est. primary completion 2027-01-28 · NCT07358520 · CT.gov ↗
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March 2027 (1)
Phase 2Hepatocellular Carcinoma (HCC)Recruiting
Est. primary completion 2027-03-31 · NCT07413354 · CT.gov ↗
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May 2027 (1)
Phase 4Nephropathy, Glomerular Diseases, Idiopathic Membranous NephropathyRecruiting
Est. primary completion 2027-05-03 · NCT05839314 · CT.gov ↗
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June 2027 (1)
Phase 2Proteinuria, Breast Cancer PatientsNot yet recruiting
Est. primary completion 2027-06-15 · NCT07355361 · CT.gov ↗
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July 2027 (1)
Phase 4Colorectal CancerRecruiting
Est. primary completion 2027-07 · NCT06090994 · CT.gov ↗
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December 2027 (1)
Phase 4Carcinoma Breast, Triple-negative Breast Cancer, Invasive Ductal Carcinoma, BreastRecruiting
Est. primary completion 2027-12-31 · NCT04790305 · CT.gov ↗
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2028 (2)
March 2028 (1)
Phase 4Pancreatic Cancer Non-resectableNot yet recruiting
Est. primary completion 2028-03 · NCT06387368 · CT.gov ↗
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June 2028 (1)
Phase 3Non-Small Cell Lung CancerNot yet recruiting
Est. primary completion 2028-06-30 · NCT07197853 · CT.gov ↗
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2029 (1)
July 2029 (1)
Phase 4Gastric CancerNot yet recruiting
Est. primary completion 2029-07-01 · NCT05498766 · CT.gov ↗
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See the full readout calendar ↗

All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 3 (3)
Phase 2/3 (1)
Phase 2 (3)
Phase 4 (14)
Early phase / not applicable (3)