Asset profile
Aflibercept · Eylea
Protein / enzyme therapeutic
Evidence outlook
Approved: Age-Related Macular Degeneration
Regulatory approval supersedes design-level evidence grading; the trials behind approval are preserved below as the drug's evidence history.
track record: Reliable signal
How the evidence outlook works ↗
Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
42 competitors in this universe: 11 direct rivals (same mechanism and indication), 11 same-class, 20 same-indication.
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| Aflibercept (Eylea): this drug | Approved | Protein / enzyme therapeutic | VEGF-A, VEGF-A / VEGF-B / Placental Growth Factor (PlGF) | ||
| Brolucizumab-Dbll | Approved | Monoclonal antibody | VEGF-A | ||
| Pegaptanib (Macugen) | Approved | Small molecule | VEGF-A | ||
| Ranibizumab (Lucentis) | Approved | Monoclonal antibody | VEGF-A | ||
| ABBV-RGX-314 | Phase 3 | Gene therapy / editing | VEGF-A | ||
| CKD-701 | Phase 3 | Monoclonal antibody | VEGF-A | ||
| HLX04-O | Phase 3 | Monoclonal antibody | VEGF-A | ||
| KSI-301 | Phase 3 | Monoclonal antibody | VEGF-A | ||
| RGX-314 | Phase 3 | Gene therapy / editing | VEGF-A | ||
| Surabgene Lomparvovec (ABBV-RGX-314) | Phase 3 | Gene therapy / editing | VEGF-A | ||
| Tarcocimab Tedromer | Phase 3 | Monoclonal antibody | VEGF-A | ||
| MW02 | Phase 2/3 | Monoclonal antibody | VEGF-A | ||
| Alymsys (bevacizumab-Maly) | Approved | Monoclonal antibody | VEGF-A | ||
| BAT1706 (Avzivi) | Approved | Monoclonal antibody | VEGF-A | ||
| Bevacizumab | Approved | Monoclonal antibody | VEGF-A, Vascular Endothelial Growth Factor Inhibitor | ||
| Bevacizumab-Awwb (MVASI) | Approved | Monoclonal antibody | VEGF-A |
…and 27 more. Research shows the complete landscape.
Unlock the full comparison
Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
Compare head-to-head
5 further head-to-head pairs are tracked; the rosters on each shared mechanism and indication page list every rival in the race.
Upcoming events
(20 total)
Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.
2026 (1)
December 2026 (1)
What to watch
2027 (9)
January 2027 (1)
What to watch
February 2027 (1)
What to watch
April 2027 (2)
June 2027 (1)
What to watch
July 2027 (1)
What to watch
September 2027 (1)
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November 2027 (1)
What to watch
December 2027 (1)
What to watch
2028 (7)
February 2028 (1)
What to watch
May 2028 (1)
June 2028 (2)
July 2028 (1)
What to watch
November 2028 (1)
What to watch
December 2028 (1)
What to watch
2029 (1)
February 2029 (1)
What to watch
2030 (1)
October 2030 (1)
What to watch
2031 (1)
June 2031 (1)
What to watch
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.