Asset profile
Avacincaptad pegol · Izervay
Other
Evidence outlook
Approved: Age-Related Macular Degeneration
Regulatory approval supersedes design-level evidence grading; the trials behind approval are preserved below as the drug's evidence history.
track record: Reliable signal
How the evidence outlook works ↗
Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
34 competitors in this universe: 2 direct rivals (same mechanism and indication), 3 same-class, 29 same-indication.
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| Avacincaptad Pegol (Izervay): this drug | Approved | Rna Aptamer | Complement C5 | ||
| Cemdisiran | Phase 3 | RNA / oligonucleotide | Complement C5 | ||
| ABBV-6628 | Phase 1/2 | Antibody fragment | Complement C5 | ||
| Eculizumab (Soliris) | Phase 3 | Monoclonal antibody | Complement C5 | ||
| Pozelimab | Phase 3 | Monoclonal antibody | Complement C5 | ||
| Ravulizumab (Ultomiris) | Phase 3 | Monoclonal antibody | Complement C5 | ||
| Aflibercept (Eylea) | Approved | Protein / enzyme therapeutic | VEGF-A, VEGF-A / VEGF-B / Placental Growth Factor (PlGF) | ||
| Brolucizumab-Dbll | Approved | Monoclonal antibody | VEGF-A | ||
| Chloroprocaine | Approved | Small molecule | Voltage-gated sodium channels (Nav) on sensory nerve membranes | ||
| Faricimab | Approved | Multispecific antibody | Angiopoietin-2 / VEGF-A | ||
| Pegaptanib (Macugen) | Approved | Small molecule | VEGF-A | ||
| Pegcetacoplan Ophthalmic (Syfovre) | Approved | Peptide | Complement C3, Complement C3 / C3b | ||
| Ranibizumab (Lucentis) | Approved | Monoclonal antibody | VEGF-A | ||
| Verteporfin | Approved | Small molecule | Benzoporphyrin-derivative photosensitizer for photodynamic therapy | ||
| Visudyne | Approved | Small molecule | Photosensitizing agent (photodynamic therapy) | ||
| ABBV-RGX-314 | Phase 3 | Gene therapy / editing | VEGF-A |
…and 19 more. Research shows the complete landscape.
Unlock the full comparison
Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
Upcoming events
(1 total)
Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.
2027 (1)
June 2027 (1)
What to watch
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.