Asset profile
RC28-E
Protein / enzyme therapeutic
Evidence outlook · registrational
Age-Related Macular Degeneration: registrational readout pending
Entered Phase 3 on weak signal mid-stage evidence. The registry's posted readout date (2025-11-29) has passed without a status update. Check News for topline announcements.
NCT04270669: The study was open-label and non-randomized, included 37 participants across three dose groups, and had no placebo or active comparator. Its primary clinical endpoint was change in ETDRS best-corrected visual acuity at weeks 12 and 48, but the results and whether the endpoint was met are unavailable.
How the evidence outlook works ↗
Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
31 competitors in this universe: 0 direct rivals (same mechanism and indication), 0 same-class, 31 same-indication; 10 further along in development.
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| RC28-E: this drug | Phase 3 | Protein / enzyme therapeutic | VEGF-A / FGF-2 (dual blockade) | ||
| Aflibercept (Eylea) | Approved | Protein / enzyme therapeutic | VEGF-A, VEGF-A / VEGF-B / Placental Growth Factor (PlGF) | ||
| Avacincaptad Pegol (Izervay) | Approved | Rna Aptamer | Complement C5 | ||
| Brolucizumab-Dbll | Approved | Monoclonal antibody | VEGF-A | ||
| Chloroprocaine | Approved | Small molecule | Voltage-gated sodium channels (Nav) on sensory nerve membranes | ||
| Faricimab | Approved | Multispecific antibody | Angiopoietin-2 / VEGF-A | ||
| Pegaptanib (Macugen) | Approved | Small molecule | VEGF-A | ||
| Pegcetacoplan Ophthalmic (Syfovre) | Approved | Peptide | Complement C3, Complement C3 / C3b | ||
| Ranibizumab (Lucentis) | Approved | Monoclonal antibody | VEGF-A | ||
| Verteporfin | Approved | Small molecule | Benzoporphyrin-derivative photosensitizer for photodynamic therapy | ||
| Visudyne | Approved | Small molecule | Photosensitizing agent (photodynamic therapy) | ||
| ABBV-RGX-314 | Phase 3 | Gene therapy / editing | VEGF-A | ||
| ABP 938 | Phase 3 | Protein / enzyme therapeutic | VEGF-A / VEGF-B / PlGF | ||
| ANX007 | Phase 3 | Monoclonal antibody | Complement C1q | ||
| Cemdisiran | Phase 3 | RNA / oligonucleotide | Complement C5 | ||
| CKD-701 | Phase 3 | Monoclonal antibody | VEGF-A |
…and 16 more. Research shows the complete landscape.
Unlock the full comparison
Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
Upcoming events
No upcoming readouts on record for this asset.
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.