Asset profile

vedolizumab · Entyvio

Monoclonal antibody

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Approvedregulatory verdict

Evidence outlook

Approved: Crohn's Disease, Ulcerative Colitis

Regulatory approval supersedes design-level evidence grading; the trials behind approval are preserved below as the drug's evidence history.

track record: Reliable signal

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Competitive landscape

86 competitors in this universe: 2 direct rivals (same mechanism and indication), 1 same-class, 83 same-indication.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
Vedolizumab (Entyvio): this drugApprovedMonoclonal antibodyα4β7 integrin
Morf-057Phase 2Small moleculeα4β7 integrin
SPY001Phase 2Monoclonal antibodyα4β7 integrin
TrosunilimabPhase 2Monoclonal antibodyα4β7 integrin
Adalimumab (Humira)ApprovedMonoclonal antibodyTNF-alpha
Adalimumab-Aacf (Idacio)Approved—TNF-alpha
Adalimumab-Aaty (Yuflyma)Approved—TNF-alpha
Adalimumab-Adaz (Hyrimoz)Approved—TNF-alpha
Adalimumab-Adbm (Cyltezo)ApprovedMonoclonal antibodyTNF-alpha
Adalimumab-Afzb (Abrilada)Approved—TNF-alpha
Adalimumab-Aqvh (Yusimry)Approved—TNF-alpha
Adalimumab-Atto (Amjevita)Approved—TNF-alpha
Adalimumab-Bwwd (Hadlima)Approved—TNF-alpha
Adalimumab-Fkjp (Hulio)Approved—TNF-alpha
Adalimumab-Ryvk (Simlandi)Approved—TNF-alpha
Balsalazide Disodium (Colazal)Approved—Aminosalicylate

…and 71 more. Research shows the complete landscape.

Research

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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(25 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2026 (1)
October 2026 (1)
Phase 1Clinical Stage 0 Cutaneous Melanoma AJCC v8, Clinical Stage I Cutaneous Melanoma AJCC v8, Clinical Stage IA Cutaneous Melanoma AJCC v8 …Recruiting
Est. primary completion 2026-10-31 · NCT03819296 · CT.gov ↗
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2027 (13)
May 2027 (1)
Phase 4Crohn's DiseaseRecruiting
Est. primary completion 2027-05-01 · NCT06581328 · CT.gov ↗
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June 2027 (3)
Phase 3Crohn's DiseaseRecruiting
Est. primary completion 2027-06-08 · NCT06227910 · CT.gov ↗
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Phase 4Ulcerative ColitisNot yet recruiting
Est. primary completion 2027-06-23 · NCT07665294 · CT.gov ↗
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Phase 4Crohn's DiseaseRecruiting
Est. primary completion 2027-06-28 · NCT06045754 · CT.gov ↗
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July 2027 (2)
Phase 4Ulcerative ColitisRecruiting
Est. primary completion 2027-07-09 · NCT06095128 · CT.gov ↗
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Phase 4Crohn's DiseaseRecruiting
Est. primary completion 2027-07-30 · NCT05928039 · CT.gov ↗
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August 2027 (2)
Phase 3Ulcerative ColitisActive not recruiting
Est. primary completion 2027-08 · NCT06880744 · CT.gov ↗
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Phase 4Crohn's DiseaseNot yet recruiting
Est. primary completion 2027-08-30 · NCT06788340 · CT.gov ↗
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September 2027 (2)
Phase 3Crohn's DiseaseRecruiting
Est. primary completion 2027-09-13 · NCT04779320 · CT.gov ↗
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Phase 3Ulcerative ColitisActive not recruiting
Est. primary completion 2027-09-24 · NCT03221036 · CT.gov ↗
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October 2027 (1)
Phase 4Crohn's DiseaseRecruiting
Est. primary completion 2027-10-31 · NCT06180382 · CT.gov ↗
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December 2027 (2)
Phase 1/2Colitis, Lung Non-Small Cell Carcinoma, Malignant Genitourinary System Neoplasm, Malignant Solid Neoplasm, MelanomaActive not recruiting
Est. primary completion 2027-12-31 · NCT04407247 · CT.gov ↗
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Phase 4Ulcerative ColitisRecruiting
Est. primary completion 2027-12-31 · NCT06609447 · CT.gov ↗
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2028 (4)
April 2028 (1)
Phase 3Ulcerative ColitisNot yet recruiting
Est. primary completion 2028-04-30 · NCT06614387 · CT.gov ↗
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May 2028 (1)
Phase 3Crohn's DiseaseRecruiting
Est. primary completion 2028-05-16 · NCT06100289 · CT.gov ↗
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October 2028 (2)
Phase 2Crohn's DiseaseRecruiting
Est. primary completion 2028-10 · NCT03219359 · CT.gov ↗
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Phase 2Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Chronic Myelomonocytic Leukemia, Graft Versus Host Disease, Myelodysplastic Syndrome …Recruiting
Est. primary completion 2028-10-15 · NCT06815003 · CT.gov ↗
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2029 (1)
January 2029 (1)
Phase 4Crohn's DiseaseRecruiting
Est. primary completion 2029-01-03 · NCT06257706 · CT.gov ↗
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2030 (5)
January 2030 (1)
Phase 3PouchitisRecruiting
Est. primary completion 2030-01-31 · NCT06443502 · CT.gov ↗
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March 2030 (1)
Phase 3Crohn's DiseaseRecruiting
Est. primary completion 2030-03-08 · NCT05837897 · CT.gov ↗
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June 2030 (1)
Phase 4Ulcerative ColitisNot yet recruiting
Est. primary completion 2030-06-01 · NCT07576452 · CT.gov ↗
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August 2030 (1)
Phase 3Crohn's DiseaseRecruiting
Est. primary completion 2030-08-12 · NCT06405087 · CT.gov ↗
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December 2030 (1)
Phase 2/3IrAE, Immune-related Adverse Event, Diarrhea, ColitisRecruiting
Est. primary completion 2030-12-01 · NCT06337695 · CT.gov ↗
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2033 (1)
February 2033 (1)
Phase 3Crohn's DiseaseRecruiting
Est. primary completion 2033-02-07 · NCT05442567 · CT.gov ↗
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See the full readout calendar ↗

All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 3 (32)
Phase 2/3 (2)
Phase 2 (17)
Phase 1/2 (3)
Phase 1 (15)
Phase 4 (36)
Early phase / not applicable (6)
Used as active comparator (6)
Appears in other studies (5)