Asset profile

upadacitinib · Rinvoq

Small molecule

Approvedregulatory verdict

Evidence outlook

Approved — Atopic Dermatitis, Crohn's Disease, Rheumatoid Arthritis, Ulcerative Colitis

Regulatory approval supersedes design-level evidence grading — the trials behind approval are preserved below as the drug's evidence history.

Also in development:Systemic Lupus Erythematosus · Phase 3

How the evidence outlook works ↗

Upcoming events

(13 total)

Estimated primary-completion dates from ClinicalTrials.gov — registry estimates, never confirmed readout dates; they can move as trials progress.

2026 (2)
September 2026 (1)
Phase 3Rheumatoid ArthritisActive not recruiting
Est. primary completion 2026-09-30 · NCT07008846 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

December 2026 (1)
Phase 3Crohn's DiseaseNot yet recruiting
Est. primary completion 2026-12-31 · NCT07149467 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

2027 (8)
January 2027 (1)
Phase 3Atopic DermatitisActive not recruiting
Est. primary completion 2027-01 · NCT06701331 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

March 2027 (1)
Phase 3Systemic Lupus ErythematosusActive not recruiting
Est. primary completion 2027-03 · NCT05843643 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

May 2027 (1)
Phase 3Ulcerative ColitisRecruiting
Est. primary completion 2027-05 · NCT06660693 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

June 2027 (2)
Phase 3Crohn's DiseaseRecruiting
Est. primary completion 2027-06 · NCT06332534 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 3Crohn's DiseaseRecruiting
Est. primary completion 2027-06-08 · NCT06227910 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

July 2027 (1)
Phase 3Ulcerative ColitisActive not recruiting
Est. primary completion 2027-07 · NCT03006068 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

September 2027 (1)
Phase 3Crohn's DiseaseActive not recruiting
Est. primary completion 2027-09 · NCT03345823 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

November 2027 (1)
Phase 2Atopic DermatitisNot yet recruiting
Est. primary completion 2027-11-30 · NCT07678645 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

2028 (2)
January 2028 (1)
Phase 2Rheumatic DiseaseRecruiting
Est. primary completion 2028-01 · NCT07138898 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

August 2028 (1)
Phase 3Ulcerative ColitisActive not recruiting
Est. primary completion 2028-08 · NCT05782907 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

2030 (1)
July 2030 (1)
Phase 3Atopic DermatitisRecruiting
Est. primary completion 2030-07 · NCT06461897 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

See the full readout calendar ↗

All registered studies

Research

Unlock the complete ClinicalTrials.gov registry

Research includes every linked study, indication filters, phase grouping and featured-trial cross-links.

Competitive landscape

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