Asset profile
tofacitinib · Xeljanz
Small molecule
Evidence outlook
Approved: Rheumatoid Arthritis, Psoriatic Arthritis, Ulcerative Colitis (label: moderately to severely active UC who have had an inadequate response, lost response, or were...)
Regulatory approval supersedes design-level evidence grading; the trials behind approval are preserved below as the drug's evidence history.
track record: Reliable signal
How the evidence outlook works ↗
Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
128 competitors in this universe: 3 direct rivals (same mechanism and indication), 2 same-class, 123 same-indication.
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| Tofacitinib (Xeljanz): this drug | Approved | Small molecule | JAK, JAK1/JAK3 | ||
| Baricitinib (Olumiant) | Approved | Small molecule | JAK, JAK1/2 | ||
| Upadacitinib (Rinvoq) | Approved | Small molecule | JAK, JAK1 | ||
| Filgotinib (Jyseleca) | Phase 3 | Small molecule | JAK, JAK1 | ||
| QLM3003 | Phase 3 | Small molecule | JAK | ||
| ZL-82 | Phase 2 | Small molecule | JAK | ||
| Abatacept (Orencia) | Approved | Protein / enzyme therapeutic | CD80/CD86 (CTLA-4-Ig), Selective T Cell Costimulation Modulator, CD80/CD86 (B7-1/B7-2) on antigen-presenting cells | ||
| Adalimumab (Humira) | Approved | Monoclonal antibody | TNF-alpha | ||
| Adalimumab-Aacf (Idacio) | Approved | — | TNF-alpha | ||
| Adalimumab-Aaty (Yuflyma) | Approved | — | TNF-alpha | ||
| Adalimumab-Adaz (Hyrimoz) | Approved | — | TNF-alpha | ||
| Adalimumab-Adbm (Cyltezo) | Approved | Monoclonal antibody | TNF-alpha | ||
| Adalimumab-Afzb (Abrilada) | Approved | — | TNF-alpha | ||
| Adalimumab-Aqvh (Yusimry) | Approved | — | TNF-alpha | ||
| Adalimumab-Atto (Amjevita) | Approved | — | TNF-alpha | ||
| Adalimumab-Bwwd (Hadlima) | Approved | — | TNF-alpha |
…and 113 more. Research shows the complete landscape.
Unlock the full comparison
Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
Upcoming events
(23 total)
Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.
2026 (2)
2027 (11)
January 2027 (2)
March 2027 (2)
April 2027 (1)
What to watch
May 2027 (1)
What to watch
June 2027 (1)
What to watch
July 2027 (2)
October 2027 (1)
What to watch
December 2027 (1)
What to watch
2028 (4)
January 2028 (1)
What to watch
March 2028 (1)
What to watch
August 2028 (1)
What to watch
October 2028 (1)
What to watch
2029 (3)
April 2029 (1)
What to watch
May 2029 (1)
What to watch
December 2029 (1)
What to watch
2030 (3)
June 2030 (1)
What to watch
August 2030 (1)
December 2030 (1)
What to watch
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.