Asset profile
Henagliflozin
Small molecule
Evidence outlook · lead readout
NCT04390295 · Type 2 Diabetes Mellitus
The completed lead evidence has the design features that historically survive confirmatory trials: randomized, controlled, and adequately powered against a prespecified clinically accepted endpoint.
NCT04390295: This was a randomized, quadruple-blind, placebo-controlled trial (n=450) adding henagliflozin or placebo onto metformin. The primary endpoint, HbA1c change at 24 weeks, was clearly met: both doses reduced HbA1c significantly more than placebo (p<.0001 for each).
How the evidence outlook works ↗
Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
80 competitors in this universe: 19 direct rivals (same mechanism and indication), 1 same-class, 60 same-indication; 33 further along in development.
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| Henagliflozin: this drug | Phase 3 | Small molecule | DPP-4, Sodium-glucose cotransporter 2 (SGLT2) | ||
| Alogliptin (Nesina) | Approved | Small molecule | DPP-4 | ||
| Linagliptin (Tradjenta) | Approved | Small molecule | DPP-4 | ||
| Saxagliptin (Onglyza) | Approved | Small molecule | DPP-4 | ||
| Sitagliptin (Januvia) | Approved | Small molecule | DPP-4 | ||
| Anagliptin (Suiny) | Phase 3 | Small molecule | DPP-4 | ||
| DBPR108 | Phase 3 | Small molecule | DPP-4 | ||
| Evogliptin (Suganon) | Phase 3 | Small molecule | DPP-4 | ||
| Gemigliptin (Zemiglo) | Phase 3 | Small molecule | DPP-4 | ||
| Gosogliptin | Phase 3 | Small molecule | DPP-4 | ||
| MP-513 | Phase 3 | Small molecule | DPP-4 | ||
| Omarigliptin (Marizev) | Phase 3 | Small molecule | DPP-4 | ||
| SP2086 | Phase 3 | Small molecule | DPP-4 | ||
| SYR-472 | Phase 3 | Small molecule | DPP-4 | ||
| Teneligliptin (Tenelia) | Phase 3 | Small molecule | DPP-4 | ||
| Trelagliptin (Zafatek) | Phase 3 | Small molecule | DPP-4 |
…and 65 more. Research shows the complete landscape.
Unlock the full comparison
Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
Compare head-to-head
13 further head-to-head pairs are tracked; the rosters on each shared mechanism and indication page list every rival in the race.
Upcoming events
(6 total)
Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.
2026 (2)
2027 (3)
September 2027 (1)
What to watch
2028 (1)
December 2028 (1)
What to watch
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.