Asset profile
ALN-ANG3
RNA / oligonucleotide
Evidence outlook
Mid-stage studies underway, no completed readout
Phase 2 studies are registered but none has completed a readout, so no evidence signal is assigned yet. The first graded signal arrives with a completed confirmatory readout.
Also in development:Atherosclerotic Cardiovascular Disease · Phase 1
How the evidence outlook works ↗
Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
127 competitors in this universe: 9 direct rivals (same mechanism and indication), 1 same-class, 117 same-indication; 116 further along in development.
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| ALN-ANG3: this drug | Phase 2 | RNA / oligonucleotide | ANGPTL3 | ||
| Evinacumab (Evkeeza) | Phase 3 | Monoclonal antibody | ANGPTL3 | ||
| BW-00112 | Phase 2 | RNA / oligonucleotide | ANGPTL3 | ||
| EDP167 | Phase 2 | RNA / oligonucleotide | ANGPTL3 | ||
| HRS-7249 | Phase 2 | Unknown Undisclosed | ANGPTL3 | ||
| Solbinsiran | Phase 2 | RNA / oligonucleotide | ANGPTL3 | ||
| SYH2070 | Phase 2 | RNA / oligonucleotide | ANGPTL3 | ||
| AZD1705 | Phase 1 | Small molecule | ANGPTL3 | ||
| CTX310 | Phase 1 | Gene therapy / editing | ANGPTL3 | ||
| NNC0491-6075 | Phase 1 | Unknown Undisclosed | ANGPTL3 | ||
| SHR-1918 | Phase 3 | Monoclonal antibody | ANGPTL3 | ||
| Alirocumab (Praluent) | Approved | Monoclonal antibody | PCSK9 | ||
| Atrasentan (Vanrafia) | Approved | Small molecule | Endothelin A receptor | ||
| Avacopan (Tavneos) | Approved | Small molecule | Complement C5a receptor 1 (C5aR1/CD88) | ||
| Baxdrostat (Baxfendy) | Approved | Small molecule | Aldosterone synthase (CYP11B2) | ||
| Bempedoic Acid (Nexletol) | Approved | Small molecule | Adenosine Triphosphate-Citrate Lyase Inhibitor, ATP citrate lyase |
…and 112 more. Research shows the complete landscape.
Unlock the full comparison
Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
Upcoming events
(2 total)
Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.