Asset profile
Molidustat
Small molecule
Evidence outlook · lead readout
MIYABI HD-M (NCT03543657) · Anemia, Renal Insufficiency, Chronic
The completed lead evidence is positive, with design limits that temper confidence; the rationale below says which.
MIYABI HD-M (NCT03543657): The trial randomized 229 participants to molidustat or darbepoetin alfa with matching placebos and quadruple blinding. Its primary endpoints were hemoglobin measures, which are laboratory surrogate outcomes, and no primary results or statistical comparison are available.
How the evidence outlook works ↗
Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
67 competitors in this universe: 7 direct rivals (same mechanism and indication), 0 same-class, 60 same-indication; 25 further along in development.
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| Molidustat: this drug | Phase 3 | Small molecule | HIF prolyl hydroxylase (HIF-PH1/2/3) | ||
| Daprodustat (Jesduvroq) | Approved | Small molecule | HIF prolyl hydroxylase (HIF-PH1/2/3) | ||
| Vadadustat (Vafseo) | Approved | Small molecule | HIF prolyl hydroxylase (HIF-PH1/2/3) | ||
| AND017 | Phase 3 | Small molecule | HIF prolyl hydroxylase (HIF-PH1/2/3) | ||
| Desidustat (Oxemia) | Phase 3 | Small molecule | HIF prolyl hydroxylase (HIF-PH1/2/3) | ||
| Enarodustat | Phase 3 | Small molecule | HIF prolyl hydroxylase (HIF-PH1/2/3) | ||
| Roxadustat (Evrenzo) | Phase 3 | Small molecule | HIF prolyl hydroxylase (HIF-PH1/2/3) | ||
| SSS17 | Phase 2 | Small molecule | HIF prolyl hydroxylase (HIF-PH1/2/3) | ||
| Atrasentan (Vanrafia) | Approved | Small molecule | Endothelin A receptor | ||
| Avacopan (Tavneos) | Approved | Small molecule | Complement C5a receptor 1 (C5aR1/CD88) | ||
| Baxdrostat (Baxfendy) | Approved | Small molecule | Aldosterone synthase (CYP11B2) | ||
| Budesonide (targeted-Release) (TARPEYO / Nefecon) | Approved | Small molecule | Glucocorticoid receptor | ||
| Canagliflozin (Invokana) | Approved | Small molecule | SGLT2 | ||
| Dapagliflozin (Farxiga / Forxiga) | Approved | Small molecule | SGLT2 | ||
| Difelikefalin (Korsuva) | Approved | Peptide | Kappa-opioid receptor (agonist, peripherally restricted) | ||
| Empagliflozin (Jardiance) | Approved | Small molecule | SGLT2 |
…and 52 more. Research shows the complete landscape.
Unlock the full comparison
Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
Compare head-to-head
1 further head-to-head pair is tracked; the rosters on each shared mechanism and indication page list every rival in the race.
Upcoming events
No upcoming readouts on record for this asset.
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.