Asset profile

Eribulin mesylate

Small molecule

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Approvedregulatory verdict

Evidence outlook

Approved: HR+/HER2- Metastatic Breast Cancer (label: metastatic breast cancer of any HR or HER2 status, after two or more prior chemotherapy regimens)

Regulatory approval supersedes design-level evidence grading; the trials behind approval are preserved below as the drug's evidence history.

track record: Partial signal

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Competitive landscape

61 competitors in this universe: 1 direct rival (same mechanism and indication), 0 same-class, 60 same-indication.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
Eribulin Mesylate: this drugApprovedSmall moleculeTubulin / microtubules
UtidelonePhase 3Small moleculeTubulin / microtubules
Abemaciclib (Verzenio)ApprovedSmall moleculeCDK4 and CDK6
Alpelisib (BYL719)ApprovedSmall moleculePI3K-alpha
AnastrozoleApprovedSmall moleculeAromatase
CapecitabineApprovedSmall moleculeFluoropyrimidine (antimetabolite)
CapivasertibApprovedSmall moleculeAKT (inhibitor)
Datopotamab DeruxtecanApprovedAntibody–drug conjugateTROP2
DenosumabApprovedMonoclonal antibodyRANKL
DocetaxelApprovedSmall moleculeMicrotubules (tubulin)
ElacestrantApprovedSmall moleculeEstrogen receptor
EverolimusApprovedSmall moleculemTOR kinase, mTOR (mTORC1) (inhibitor)
ExemestaneApprovedSmall moleculeAromatase
Fulvestrant (Faslodex)ApprovedSmall moleculeEstrogen receptor
GedatolisibApprovedSmall moleculePI3K (class I isoforms) and mTORC1/mTORC2
GemcitabineApprovedSmall moleculeribonucleotide reductase / DNA polymerase (dCTP competition)

…and 46 more. Research shows the complete landscape.

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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(30 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2026 (3)
December 2026 (3)
Phase 1/2HR+/HER2- Metastatic Breast CancerRecruiting
Est. primary completion 2026-12 · NCT06202261 · CT.gov ↗
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Phase 2HR+/HER2- Metastatic Breast CancerNot yet recruiting
Est. primary completion 2026-12-01 · NCT07255612 · CT.gov ↗
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Phase 1Refractory Solid TumorsRecruiting
Est. primary completion 2026-12-31 · NCT06006273 · CT.gov ↗
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2027 (13)
January 2027 (1)
Phase 1HER2-positive Breast Cancer, HER2-positive Gastric Cancer, HER2 Positive Solid Tumors, HER2 Amplification, Colorectal CancerActive not recruiting
Est. primary completion 2027-01 · NCT06328738 · CT.gov ↗
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March 2027 (1)
Phase 1/2Solid NeoplasmsActive not recruiting
Est. primary completion 2027-03-31 · NCT04078295 · CT.gov ↗
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June 2027 (4)
Phase 2Triple Negative Breast Cancer (TNBC), Metastatic Breast CancerNot yet recruiting
Est. primary completion 2027-06 · NCT06731153 · CT.gov ↗
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Phase 2Breast Cancer, Pretreated Unresectable Locally Advanced or Metastatic HER2+ Breast CancerActive not recruiting
Est. primary completion 2027-06-01 · NCT05458674 · CT.gov ↗
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Phase 1/2HR+/HER2- Metastatic Breast CancerRecruiting
Est. primary completion 2027-06-30 · NCT06942234 · CT.gov ↗
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Phase 2Locally Advanced Bladder Urothelial Carcinoma, Locally Advanced Renal Pelvis Urothelial Carcinoma …Active not recruiting
Est. primary completion 2027-06-30 · NCT03237780 · CT.gov ↗
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July 2027 (1)
Phase 3HR+/HER2- Metastatic Breast CancerRecruiting
Est. primary completion 2027-07-24 · NCT07088263 · CT.gov ↗
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October 2027 (1)
Phase 2Breast Cancer, Metastatic Triple-Negative Breast CancerRecruiting
Est. primary completion 2027-10 · NCT05570253 · CT.gov ↗
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November 2027 (1)
Phase 2Brest CancerNot yet recruiting
Est. primary completion 2027-11-20 · NCT07333937 · CT.gov ↗
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December 2027 (4)
Phase 2HR+/HER2- Metastatic Breast CancerRecruiting
Est. primary completion 2027-12 · NCT07007559 · CT.gov ↗
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Phase 1/2HR+/HER2- Metastatic Breast CancerNot yet recruiting
Est. primary completion 2027-12-31 · NCT07494448 · CT.gov ↗
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Phase 2Recurrent Breast Inflammatory Carcinoma, Stage IV Breast Inflammatory CarcinomaActive not recruiting
Est. primary completion 2027-12-31 · NCT03202316 · CT.gov ↗
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Phase 2Soft Tissue Sarcoma (STS)Not yet recruiting
Est. primary completion 2027-12-31 · NCT07205185 · CT.gov ↗
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2028 (7)
March 2028 (2)
Phase 2TNBC - Triple-Negative Breast Cancer, TNBCNot yet recruiting
Est. primary completion 2028-03-15 · NCT07441512 · CT.gov ↗
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Phase 2HR+/HER2- Metastatic Breast CancerNot yet recruiting
Est. primary completion 2028-03-31 · NCT07824869 · CT.gov ↗
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April 2028 (1)
Phase 3Metastatic HER2-positive Breast CancerRecruiting
Est. primary completion 2028-04-28 · NCT06435429 · CT.gov ↗
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June 2028 (2)
Phase 2HR+/HER2- Metastatic Breast CancerRecruiting
Est. primary completion 2028-06-01 · NCT04986579 · CT.gov ↗
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Phase 2HR+/HER2- Metastatic Breast CancerRecruiting
Est. primary completion 2028-06-30 · NCT05530057 · CT.gov ↗
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August 2028 (1)
Phase 2Locally Advanced Breast Cancer, Triple Negative Breast Cancer, Metastatic Triple Negative Breast CancersActive not recruiting
Est. primary completion 2028-08 · NCT06449222 · CT.gov ↗
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December 2028 (1)
Phase 3HR+/HER2- Metastatic Breast CancerRecruiting
Est. primary completion 2028-12-31 · NCT06889688 · CT.gov ↗
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2029 (2)
May 2029 (1)
Phase 2HR+/HER2- Metastatic Breast CancerRecruiting
Est. primary completion 2029-05 · NCT06875128 · CT.gov ↗
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December 2029 (1)
Phase 3HR+/HER2- Metastatic Breast CancerRecruiting
Est. primary completion 2029-12 · NCT07173751 · CT.gov ↗
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2030 (4)
April 2030 (1)
Phase 2HR+/HER2- Metastatic Breast CancerRecruiting
Est. primary completion 2030-04-30 · NCT07520760 · CT.gov ↗
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August 2030 (1)
Phase 3Metastatic Bladder Urothelial Carcinoma, Metastatic Urothelial Carcinoma, Refractory Bladder Urothelial Carcinoma …Active not recruiting
Est. primary completion 2030-08-15 · NCT04579224 · CT.gov ↗
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September 2030 (2)
Phase 1/2HR+/HER2- Metastatic Breast CancerNot yet recruiting
Est. primary completion 2030-09-01 · NCT07811232 · CT.gov ↗
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Phase 1/2HR+/HER2- Metastatic Breast CancerRecruiting
Est. primary completion 2030-09-30 · NCT03424005 · CT.gov ↗
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2031 (1)
May 2031 (1)
Phase 1Advanced Leiomyosarcoma, Adipocytic Sarcoma, Advanced LiposarcomaRecruiting
Est. primary completion 2031-05-31 · NCT06957431 · CT.gov ↗
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All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 3 (20)
Phase 2 (97)
Phase 1/2 (25)
Phase 1 (38)
Phase 4 (4)
Early phase / not applicable (2)
Used as active comparator (26)
Appears in other studies (1)