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Epirubicin

Small molecule

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Partialdesign only

Evidence outlook · results not reported

NCT00002529 · Breast Cancer

The lead study's design has limits that temper confidence (see the rationale below), and its results have not been reported. This tier describes the design, not an outcome.

NCT00002529: The study was randomized and included active comparator groups, with 452 participants, but it was not blinded. Overall survival was the primary clinical endpoint; however, no results are posted, so whether the primary endpoint was met or missed is unknown.

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Competitive landscape

60 competitors in this universe: 0 direct rivals (same mechanism and indication), 0 same-class, 60 same-indication; 29 further along in development.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
Epirubicin: this drugPhase 3Small moleculeTopoisomerase II / DNA
Abemaciclib (Verzenio)ApprovedSmall moleculeCDK4 and CDK6
Alpelisib (BYL719)ApprovedSmall moleculePI3K-alpha
AnastrozoleApprovedSmall moleculeAromatase
CapecitabineApprovedSmall moleculeFluoropyrimidine (antimetabolite)
CapivasertibApprovedSmall moleculeAKT (inhibitor)
Datopotamab DeruxtecanApprovedAntibody–drug conjugateTROP2
DenosumabApprovedMonoclonal antibodyRANKL
DocetaxelApprovedSmall moleculeMicrotubules (tubulin)
ElacestrantApprovedSmall moleculeEstrogen receptor
Eribulin MesylateApprovedSmall moleculeTubulin / microtubules
EverolimusApprovedSmall moleculemTOR kinase, mTOR (mTORC1) (inhibitor)
ExemestaneApprovedSmall moleculeAromatase
Fulvestrant (Faslodex)ApprovedSmall moleculeEstrogen receptor
GedatolisibApprovedSmall moleculePI3K (class I isoforms) and mTORC1/mTORC2
GemcitabineApprovedSmall moleculeribonucleotide reductase / DNA polymerase (dCTP competition)

…and 45 more. Research shows the complete landscape.

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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(34 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2026 (7)
October 2026 (1)
Phase 2Multiple Myeloma, Primary Plasma Cell Leukemia, Extramedullary Multiple MyelomaRecruiting
Est. primary completion 2026-10-20 · NCT06140966 · CT.gov ↗
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December 2026 (6)
Phase 1HR+/HER2- Metastatic Breast CancerRecruiting
Est. primary completion 2026-12 · NCT02897700 · CT.gov ↗
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Phase 2/3HR+/HER2- Metastatic Breast CancerActive not recruiting
Est. primary completion 2026-12-01 · NCT04290793 · CT.gov ↗
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Phase 1Osteosarcoma, Soft Tissue Sarcoma (STS)Not yet recruiting
Est. primary completion 2026-12-30 · NCT06699576 · CT.gov ↗
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Phase 2HR+/HER2- Metastatic Breast CancerRecruiting
Est. primary completion 2026-12-31 · NCT05978648 · CT.gov ↗
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Phase 2Bladder Cancer, Non-muscle InvasiveActive not recruiting
Est. primary completion 2026-12-31 · NCT05024734 · CT.gov ↗
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Phase 2/3Gastric CancerActive not recruiting
Est. primary completion 2026-12-31 · NCT01924819 · CT.gov ↗
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2027 (12)
March 2027 (2)
Phase 2Triple Negative Breast CancerRecruiting
Est. primary completion 2027-03 · NCT04771871 · CT.gov ↗
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Phase 3HR+/HER2- Metastatic Breast CancerActive not recruiting
Est. primary completion 2027-03 · NCT02455141 · CT.gov ↗
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April 2027 (1)
Phase 2HR+/HER2- Metastatic Breast CancerRecruiting
Est. primary completion 2027-04-30 · NCT05900206 · CT.gov ↗
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June 2027 (1)
Phase 4HR+/HER2- Metastatic Breast CancerRecruiting
Est. primary completion 2027-06-10 · NCT05420454 · CT.gov ↗
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July 2027 (2)
Phase 4HR+/HER2- Metastatic Breast CancerRecruiting
Est. primary completion 2027-07-10 · NCT05420467 · CT.gov ↗
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Phase 1/2HR+/HER2- Metastatic Breast CancerRecruiting
Est. primary completion 2027-07-30 · NCT07739485 · CT.gov ↗
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September 2027 (1)
Early phase / not applicableHR+/HER2- Metastatic Breast CancerNot yet recruiting
Est. primary completion 2027-09 · NCT05287308 · CT.gov ↗
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December 2027 (5)
Phase 3Peripheral T-cell Lymphoma Targeted TherapyEnrolling by invitation
Est. primary completion 2027-12-01 · NCT05678933 · CT.gov ↗
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Phase 2Adenoid Cystic Carcinoma, Sinonasal Carcinoma, EpirubicinRecruiting
Est. primary completion 2027-12-12 · NCT07320508 · CT.gov ↗
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Phase 2HR+/HER2- Metastatic Breast CancerRecruiting
Est. primary completion 2027-12-31 · NCT06964906 · CT.gov ↗
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Phase 2HR+/HER2- Metastatic Breast CancerRecruiting
Est. primary completion 2027-12-31 · NCT05582499 · CT.gov ↗
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Phase 2Rare TumourNot yet recruiting
Est. primary completion 2027-12-31 · NCT06692491 · CT.gov ↗
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2028 (7)
March 2028 (2)
Phase 2HR+/HER2- Metastatic Breast CancerRecruiting
Est. primary completion 2028-03-31 · NCT06860529 · CT.gov ↗
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Phase 2Down Syndrome, Acute Lymphoblastic Leukemia, Childhood CancerActive not recruiting
Est. primary completion 2028-03-31 · NCT03286634 · CT.gov ↗
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June 2028 (1)
Phase 2Adenoid Cystic CarcinomaNot yet recruiting
Est. primary completion 2028-06-01 · NCT07616141 · CT.gov ↗
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August 2028 (1)
Phase 2Nodal T-follicular Helper Cell LymphomaNot yet recruiting
Est. primary completion 2028-08-31 · NCT07753642 · CT.gov ↗
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September 2028 (1)
Phase 2Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Triple-Negative Breast CarcinomaRecruiting
Est. primary completion 2028-09-01 · NCT07016399 · CT.gov ↗
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October 2028 (1)
Phase 2Adenoid Cystic Carcinoma, Sinonasal CarcinomaRecruiting
Est. primary completion 2028-10-01 · NCT07522879 · CT.gov ↗
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November 2028 (1)
Phase 3HR+/HER2- Metastatic Breast CancerActive not recruiting
Est. primary completion 2028-11-20 · NCT06112379 · CT.gov ↗
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2029 (2)
June 2029 (1)
Phase 2Triple Negative Breast CancerRecruiting
Est. primary completion 2029-06 · NCT06291064 · CT.gov ↗
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December 2029 (1)
Phase 2HR+/HER2- Metastatic Breast CancerRecruiting
Est. primary completion 2029-12-31 · NCT06797635 · CT.gov ↗
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2030 (2)
November 2030 (1)
Phase 2Bladder Cancer, Non-muscle Invasive Bladder Cancer, Low GradeNot yet recruiting
Est. primary completion 2030-11-30 · NCT06227065 · CT.gov ↗
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December 2030 (1)
Phase 1/2HR+/HER2- Metastatic Breast CancerRecruiting
Est. primary completion 2030-12-31 · NCT05981014 · CT.gov ↗
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2031 (1)
January 2031 (1)
Phase 3HR+/HER2- Metastatic Breast CancerActive not recruiting
Est. primary completion 2031-01-24 · NCT03725059 · CT.gov ↗
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2033 (1)
March 2033 (1)
Phase 3Breast Neoplasms, Triple Negative Breast Neoplasms, HR Low-Positive/HER2-Negative Breast NeoplasmsRecruiting
Est. primary completion 2033-03-23 · NCT06966700 · CT.gov ↗
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2034 (1)
August 2034 (1)
Phase 3Resectable HER2-positive Breast CancerRecruiting
Est. primary completion 2034-08-07 · NCT07441460 · CT.gov ↗
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2035 (1)
September 2035 (1)
Phase 3Breast Cancer, Triple Negative Breast NeoplasmsActive not recruiting
Est. primary completion 2035-09 · NCT04335669 · CT.gov ↗
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See the full readout calendar ↗

All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 3 (108)
Phase 2/3 (14)
Phase 2 (163)
Phase 1/2 (17)
Phase 1 (23)
Phase 4 (11)
Early phase / not applicable (19)
Used as active comparator (51)
Appears in other studies (9)