Asset profile
Azacitidine
Small molecule
Evidence outlook · results not reported
NCT00887068 · Leukemia, AML, MDS
The lead study's design has limits that temper confidence (see the rationale below), and its results have not been reported. This tier describes the design, not an outcome.
NCT00887068: The study was randomized and controlled, with 87 participants assigned to azacitidine and 94 to observation, but it was open-label rather than blinded. Its primary clinical endpoint, relapse-free survival, had a numerically favorable result for azacitidine. Results were not posted at the time of grading; the key result shown was recorded subsequently from the registry record.
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Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
61 competitors in this universe: 0 direct rivals (same mechanism and indication), 1 same-class, 60 same-indication; 11 further along in development.
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| Azacitidine: this drug | Phase 3 | Small molecule | DNMT1 (DNA methyltransferase 1) | ||
| Decitabine / Tetrahydrouridine (NDec) | Phase 2 | — | DNMT1 (DNA methyltransferase 1) | ||
| ASTX727 | Approved | Small molecule | Decitabine/cedazuridine fixed combination (DNMT + CDA inhibition) | ||
| Enasidenib | Approved | Small molecule | IDH2 | ||
| Gemtuzumab Ozogamicin | Approved | Antibody–drug conjugate | CD33 | ||
| Gilteritinib | Approved | Small molecule | FLT3 | ||
| Midostaurin | Approved | Small molecule | FLT3;KIT;PKC;PDGFR | ||
| Olutasidenib | Approved | Small molecule | Mutant IDH1 | ||
| Quizartinib | Approved | Small molecule | FLT3 | ||
| Revumenib | Approved | Small molecule | Menin | ||
| Tretinoin (Vesanoid) | Approved | Small molecule | RARA (retinoic acid receptor alpha); degrades the PML-RARA fusion oncoprotein in APL | ||
| Venetoclax | Approved | Small molecule | BCL-2 | ||
| Vyxeos | Approved | Small molecule | DNA synthesis (cytarabine, antimetabolite) / Topoisomerase II | ||
| 131I-Apamistamab | Phase 3 | Monoclonal antibody | CD45 | ||
| AK117 | Phase 3 | Monoclonal antibody | CD47 | ||
| APG-2575(Lisaftoclax ) | Phase 3 | Small molecule | BCL-2 |
…and 46 more. Research shows the complete landscape.
Unlock the full comparison
Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
Upcoming events
(217 total)
Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.
2026 (34)
October 2026 (3)
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November 2026 (4)
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December 2026 (27)
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2027 (84)
January 2027 (8)
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October 2027 (9)
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November 2027 (4)
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December 2027 (18)
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2028 (53)
January 2028 (5)
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February 2028 (7)
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March 2028 (3)
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April 2028 (3)
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June 2028 (7)
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July 2028 (6)
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August 2028 (1)
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September 2028 (5)
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October 2028 (1)
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December 2028 (9)
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2029 (23)
January 2029 (2)
February 2029 (1)
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May 2029 (3)
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June 2029 (4)
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July 2029 (1)
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December 2029 (6)
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2030 (19)
January 2030 (1)
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April 2030 (4)
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June 2030 (4)
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July 2030 (2)
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September 2030 (4)
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October 2030 (1)
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December 2030 (1)
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2031 (2)
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.