Asset profile

Emavusertib

Small molecule

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Earlyevidence

Evidence outlook

Mid-stage studies underway, no completed readout

Phase 2 studies are registered but none has completed a readout, so no evidence signal is assigned yet. The first graded signal arrives with a completed confirmatory readout.

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Competitive landscape

63 competitors in this universe: 0 direct rivals (same mechanism and indication), 3 same-class, 60 same-indication; 33 further along in development.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
Emavusertib: this drugPhase 2Small moleculeIRAK4
KT-474Phase 2Small moleculeIRAK4
QLS12010Phase 2Small moleculeIRAK4
LT-002-158Phase 1/2Protein / enzyme therapeuticIRAK4
ASTX727ApprovedSmall moleculeDecitabine/cedazuridine fixed combination (DNMT + CDA inhibition)
EnasidenibApprovedSmall moleculeIDH2
Gemtuzumab OzogamicinApprovedAntibody–drug conjugateCD33
GilteritinibApprovedSmall moleculeFLT3
MidostaurinApprovedSmall moleculeFLT3;KIT;PKC;PDGFR
OlutasidenibApprovedSmall moleculeMutant IDH1
QuizartinibApprovedSmall moleculeFLT3
RevumenibApprovedSmall moleculeMenin
Tretinoin (Vesanoid)ApprovedSmall moleculeRARA (retinoic acid receptor alpha); degrades the PML-RARA fusion oncoprotein in APL
VenetoclaxApprovedSmall moleculeBCL-2
VyxeosApprovedSmall moleculeDNA synthesis (cytarabine, antimetabolite) / Topoisomerase II
131I-ApamistamabPhase 3Monoclonal antibodyCD45

…and 48 more. Research shows the complete landscape.

Research

Unlock the full comparison

Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(7 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2026 (1)
December 2026 (1)
Phase 1Metastatic Colorectal Adenocarcinoma, Stage III Colorectal Cancer AJCC v8, Stage IV Colorectal Cancer AJCC v8 …Recruiting
Est. primary completion 2026-12-31 · NCT06696768 · CT.gov ↗
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2027 (3)
June 2027 (1)
Phase 1Metastatic Urothelial Carcinoma, Unresectable Urothelial CarcinomaRecruiting
Est. primary completion 2027-06-01 · NCT06439836 · CT.gov ↗
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November 2027 (1)
Phase 2Chronic Lymphocytic Leukemia, B-cell MalignanciesRecruiting
Est. primary completion 2027-11 · NCT07271667 · CT.gov ↗
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December 2027 (1)
Phase 2Myelodysplastic SyndromeNot yet recruiting
Est. primary completion 2027-12-31 · NCT07463820 · CT.gov ↗
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2028 (1)
July 2028 (1)
Phase 1Gastric Cancer, Esophageal Cancer, Stomach Cancer, Esophagus Cancer, Gastroesophageal Junction CancerRecruiting
Est. primary completion 2028-07-31 · NCT05187182 · CT.gov ↗
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2029 (1)
May 2029 (1)
Phase 2Acute Myeloid LeukemiaRecruiting
Est. primary completion 2029-05-15 · NCT05564390 · CT.gov ↗
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2030 (1)
June 2030 (1)
Phase 1Metastatic Biliary Tract Cancer, Metastatic Biliary Tract CarcinomaRecruiting
Est. primary completion 2030-06-30 · NCT07107750 · CT.gov ↗
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See the full readout calendar ↗

All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 2 (4)
Phase 1/2 (3)
Phase 1 (5)