Asset profile

zenagamtide

Peptide

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Phase 3underway

Evidence outlook · registrational

Obesity: registrational readout pending

Its supporting mid-stage evidence has not yet been graded on this platform. Registrational readout expected around 2028-06-27.

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Competitive landscape

60 competitors in this universe: 0 direct rivals (same mechanism and indication), 0 same-class, 60 same-indication; 8 further along in development.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
Zenagamtide: this drugPhase 3PeptideGLP-1 / Amylin / Calcitonin receptors
Liraglutide (Saxenda / Victoza)ApprovedPeptideGLP-1 receptor
Naltrexone / Bupropion (Contrave)ApprovedSmall moleculeOpioid receptor / dopamine (combination)
Orforglipron (Foundayo)ApprovedSmall moleculeGLP-1 receptor
Orlistat (Xenical / Alli)ApprovedSmall moleculePancreatic/gastric lipase
Phentermine / Topiramate (Qsymia)ApprovedSmall moleculeNoradrenergic/anticonvulsant (combination)
Semaglutide (Wegovy / Ozempic / Rybelsus)ApprovedPeptideGLP-1 receptor
Setmelanotide (Imcivree)ApprovedPeptideMC4R
Tirzepatide (Zepbound / Mounjaro)ApprovedPeptideGLP-1/GIP receptor (dual)
AleniglipronPhase 3Small moleculeGLP-1 receptor
AmycretinPhase 3PeptideGLP-1 receptor, Amylin receptor
ApitegromabPhase 3Monoclonal antibodyActivin/myostatin type II receptor
ARD-101Phase 3Small moleculeBitter taste receptor (gut)
ASC30Phase 3Small moleculeGLP-1 receptor
AZD6234Phase 3PeptideAmylin receptor
BGM0504Phase 3PeptideGLP-1/GIP receptor (dual)

…and 45 more. Research shows the complete landscape.

Research

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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(6 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2028 (5)
June 2028 (2)
Phase 1ObesityRecruiting
Est. primary completion 2028-06-12 · NCT07815067 · CT.gov ↗
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Phase 3ObesityRecruiting
Est. primary completion 2028-06-27 · NCT07720271 · CT.gov ↗
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July 2028 (1)
Phase 3Type 2 Diabetes, Cardiovascular RiskRecruiting
Est. primary completion 2028-07-31 · NCT07797335 · CT.gov ↗
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September 2028 (1)
Phase 1ObesityNot yet recruiting
Est. primary completion 2028-09-06 · NCT07855133 · CT.gov ↗
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October 2028 (1)
Phase 3ObesityRecruiting
Est. primary completion 2028-10-10 · NCT07668414 · CT.gov ↗
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2029 (1)
January 2029 (1)
Phase 3ObesityNot yet recruiting
Est. primary completion 2029-01-11 · NCT07668401 · CT.gov ↗
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See the full readout calendar ↗

All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 3 (4)
Phase 1 (2)