Asset profile
semaglutide · Wegovy / Ozempic / Rybelsus
Peptide
Approvedregulatory verdict
Evidence outlook
Approved: Chronic Kidney Disease, Atherosclerotic Cardiovascular Disease, Type 2 Diabetes, MASH / NASH [accelerated] (label: adults; noncirrhotic, moderate to advanced fibrosis), Obesity
Accelerated approval is granted on surrogate endpoints; confirmatory clinical benefit is being verified in ongoing trials. Regulatory approval supersedes design-level evidence grading; the trials behind approval are preserved below as the drug's evidence history.
track record: Reliable signal
How the evidence outlook works ↗
Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
303 competitors in this universe: 49 direct rivals (same mechanism and indication), 1 same-class, 253 same-indication.
Unlock with Research ↗
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| Semaglutide (Wegovy / Ozempic / Rybelsus): this drug | Approved | Peptide | GLP-1 receptor | ||
| Dulaglutide (Trulicity) | Approved | Peptide | GLP-1 receptor | ||
| Liraglutide (Saxenda / Victoza) | Approved | Peptide | GLP-1 receptor | ||
| Lixisenatide (Adlyxin / Lyxumia) | Approved | Peptide | GLP-1 receptor | ||
| Orforglipron (Foundayo) | Approved | Small molecule | GLP-1 receptor | ||
| Aleniglipron | Phase 3 | Small molecule | GLP-1 receptor | ||
| Amycretin | Phase 3 | Peptide | GLP-1 receptor, Amylin receptor | ||
| ASC30 | Phase 3 | Small molecule | GLP-1 receptor | ||
| Cagrilintide / Semaglutide (CagriSema) | Phase 3 | Peptide | Amylin receptor, GLP-1 receptor | ||
| CJC-1134-PC | Phase 3 | Peptide | GLP-1 receptor | ||
| CX11 | Phase 3 | Small molecule | GLP-1 receptor | ||
| DA-302168S | Phase 3 | Small molecule | GLP-1 receptor | ||
| Ecnoglutide | Phase 3 | Peptide | GLP-1 receptor | ||
| Efpeglenatide | Phase 3 | Peptide | GLP-1 receptor | ||
| Elecoglipron | Phase 3 | Small molecule | GLP-1 receptor | ||
| Enicepatide | Phase 3 | Peptide | GLP-1 receptor, GLP-1/GIP receptor (dual) |
…and 288 more. Research shows the complete landscape.
Research
Unlock with Research ↗Unlock the full comparison
Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
Compare head-to-head
vs dulaglutide · Type 2 Diabetes +1vs liraglutide · Obesity +2vs lixisenatide · Type 2 Diabetesvs orforglipron · Obesity +2vs aleniglipron · Obesity +1vs amycretin · Obesity +1
43 further head-to-head pairs are tracked; the rosters on each shared mechanism and indication page list every rival in the race.
Upcoming events
(157 total)
Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.
2026 (21)
October 2026 (2)
November 2026 (3)
Phase 2ObesityActive not recruiting
Est. primary completion 2026-11-20 · NCT06577090 · CT.gov ↗
What to watch
Phase 4Chronic Kidney DiseaseEnrolling by invitation
Est. primary completion 2026-11-30 · NCT06954090 · CT.gov ↗
What to watch
Early phase / not applicableType 2 DiabetesNot yet recruiting
Est. primary completion 2026-11-30 · NCT07570810 · CT.gov ↗
What to watch
December 2026 (16)
Phase 2Type 2 DiabetesActive not recruiting
Est. primary completion 2026-12 · NCT05067621 · CT.gov ↗
What to watch
Phase 4MASH / NASHEnrolling by invitation
Est. primary completion 2026-12 · NCT05195944 · CT.gov ↗
What to watch
Phase 3Type 2 DiabetesRecruiting
Est. primary completion 2026-12 · NCT07059377 · CT.gov ↗
What to watch
Phase 1ObesityNot yet recruiting
Est. primary completion 2026-12 · NCT07430059 · CT.gov ↗
What to watch
Early phase / not applicableType 2 DiabetesEnrolling by invitation
Est. primary completion 2026-12 · NCT07677995 · CT.gov ↗
What to watch
Phase 2Chronic Kidney DiseaseRecruiting
Est. primary completion 2026-12-31 · NCT05173714 · CT.gov ↗
What to watch
Phase 2Type 2 DiabetesActive not recruiting
Est. primary completion 2026-12-31 · NCT06005012 · CT.gov ↗
What to watch
Phase 2Intestinal Mucositis, Inflammation, Chemotherapeutic ToxicityNot yet recruiting
Est. primary completion 2026-12-31 · NCT06449625 · CT.gov ↗
What to watch
Phase 4Type 2 DiabetesRecruiting
Est. primary completion 2026-12-31 · NCT06461377 · CT.gov ↗
What to watch
Early phase / not applicableAdiposity, Fatty Liver, Alcohol Use DisorderNot yet recruiting
Est. primary completion 2026-12-31 · NCT06546384 · CT.gov ↗
What to watch
Early phase / not applicableObesityNot yet recruiting
Est. primary completion 2026-12-31 · NCT06825793 · CT.gov ↗
What to watch
Phase 4Diabetes Mellitus, Cardiovascular Diseases, Cerebrovascular DiseaseEnrolling by invitation
Est. primary completion 2026-12-31 · NCT06959784 · CT.gov ↗
What to watch
Early phase / not applicableObesityRecruiting
Est. primary completion 2026-12-31 · NCT06989203 · CT.gov ↗
What to watch
Phase 4ObesityEnrolling by invitation
Est. primary completion 2026-12-31 · NCT07057310 · CT.gov ↗
What to watch
Phase 4Type 2 DiabetesNot yet recruiting
Est. primary completion 2026-12-31 · NCT07165158 · CT.gov ↗
What to watch
2027 (63)
January 2027 (9)
Early phase / not applicableObesityRecruiting
Est. primary completion 2027-01 · NCT04174755 · CT.gov ↗
What to watch
Phase 2/3Type 1 Diabetes, Diabetes MellitusRecruiting
Est. primary completion 2027-01 · NCT06387199 · CT.gov ↗
What to watch
Phase 2Cocaine Use Disorder, HIVActive not recruiting
Est. primary completion 2027-01 · NCT06691243 · CT.gov ↗
What to watch
Phase 3Diabetes Type 1Recruiting
Est. primary completion 2027-01 · NCT06894784 · CT.gov ↗
What to watch
Phase 2Methamphetamine Use DisorderNot yet recruiting
Est. primary completion 2027-01 · NCT07509112 · CT.gov ↗
What to watch
Phase 4Psoriasis ArthritisNot yet recruiting
Est. primary completion 2027-01-01 · NCT07251556 · CT.gov ↗
What to watch
Phase 1ObesityActive not recruiting
Est. primary completion 2027-01-06 · NCT05202353 · CT.gov ↗
What to watch
Phase 2Type 2 DiabetesActive not recruiting
Est. primary completion 2027-01-15 · NCT06050577 · CT.gov ↗
What to watch
Early phase / not applicableType 2 DiabetesNot yet recruiting
Est. primary completion 2027-01-30 · NCT07599046 · CT.gov ↗
What to watch
February 2027 (6)
Phase 1ObesityActive not recruiting
Est. primary completion 2027-02 · NCT07223983 · CT.gov ↗
What to watch
Phase 2Trichotillomania (Hair-Pulling Disorder), Trichotillomania, Hair Pulling Disorder, Hair Pulling, Hair-Pulling DisorderNot yet recruiting
Est. primary completion 2027-02 · NCT07282769 · CT.gov ↗
What to watch
Early phase / not applicableChronic Kidney DiseaseNot yet recruiting
Est. primary completion 2027-02 · NCT07849348 · CT.gov ↗
What to watch
Phase 1Valid MeSH ConditiongsNot yet recruiting
Est. primary completion 2027-02-28 · NCT07840729 · CT.gov ↗
What to watch
March 2027 (4)
Phase 1Type 1 DiabetesRecruiting
Est. primary completion 2027-03 · NCT06338553 · CT.gov ↗
What to watch
Phase 4Type 2 DiabetesRecruiting
Est. primary completion 2027-03-08 · NCT07314684 · CT.gov ↗
What to watch
Phase 2Addiction, Alcohol Use DisorderActive not recruiting
Est. primary completion 2027-03-31 · NCT06015893 · CT.gov ↗
What to watch
April 2027 (9)
Phase 4Cardiovascular DiseasesNot yet recruiting
Est. primary completion 2027-04 · NCT07483801 · CT.gov ↗
What to watch
Early phase / not applicableObesityRecruiting
Est. primary completion 2027-04-01 · NCT06836284 · CT.gov ↗
What to watch
Early phase / not applicableObesityRecruiting
Est. primary completion 2027-04-02 · NCT07293325 · CT.gov ↗
What to watch
Phase 4ObesityActive not recruiting
Est. primary completion 2027-04-10 · NCT06184633 · CT.gov ↗
What to watch
Phase 4ObesityActive not recruiting
Est. primary completion 2027-04-28 · NCT06854614 · CT.gov ↗
What to watch
Phase 1Type 2 DiabetesRecruiting
Est. primary completion 2027-04-30 · NCT05071898 · CT.gov ↗
What to watch
Phase 3Klinefelter SyndromeRecruiting
Est. primary completion 2027-04-30 · NCT05586802 · CT.gov ↗
What to watch
Phase 2Opioid Use Disorder, Opioid Abuse and Addiction, Narcotic-Related Disorders, Substance-Related Disorders, Chemically-Induced Disorders …Recruiting
Est. primary completion 2027-04-30 · NCT06548490 · CT.gov ↗
What to watch
Phase 2MASH / NASHActive not recruiting
Est. primary completion 2027-04-30 · NCT07466017 · CT.gov ↗
What to watch
May 2027 (3)
June 2027 (6)
Phase 2Chronic Kidney DiseaseRecruiting
Est. primary completion 2027-06 · NCT05822609 · CT.gov ↗
What to watch
Early phase / not applicableType 2 DiabetesRecruiting
Est. primary completion 2027-06 · NCT07317115 · CT.gov ↗
What to watch
Phase 2ObesityNot yet recruiting
Est. primary completion 2027-06 · NCT07411378 · CT.gov ↗
What to watch
Early phase / not applicableSteroid-Induced Diabetes, Steroid Induced HyperglycemiaRecruiting
Est. primary completion 2027-06-01 · NCT06318442 · CT.gov ↗
What to watch
Phase 2ObesityActive not recruiting
Est. primary completion 2027-06-14 · NCT07639021 · CT.gov ↗
What to watch
Phase 2Alcohol Use Disorder (AUD), HIVRecruiting
Est. primary completion 2027-06-30 · NCT07040592 · CT.gov ↗
What to watch
July 2027 (5)
Phase 1Pre-Diabetes, Weight, Body, Cardiovascular DiseasesRecruiting
Est. primary completion 2027-07 · NCT06446531 · CT.gov ↗
What to watch
Phase 4Chronic Kidney DiseaseRecruiting
Est. primary completion 2027-07 · NCT07017270 · CT.gov ↗
What to watch
Phase 4ObesityActive not recruiting
Est. primary completion 2027-07-01 · NCT06803888 · CT.gov ↗
What to watch
Phase 4ObesityActive not recruiting
Est. primary completion 2027-07-31 · NCT06754163 · CT.gov ↗
What to watch
Phase 3Acute Ischemic StrokeNot yet recruiting
Est. primary completion 2027-07-31 · NCT07030621 · CT.gov ↗
What to watch
September 2027 (7)
Phase 4Chronic Kidney DiseaseActive not recruiting
Est. primary completion 2027-09 · NCT06042153 · CT.gov ↗
What to watch
Phase 4Type 2 DiabetesRecruiting
Est. primary completion 2027-09 · NCT06613854 · CT.gov ↗
What to watch
Phase 4Major Depressive DisorderRecruiting
Est. primary completion 2027-09 · NCT07136714 · CT.gov ↗
What to watch
Phase 2MASH / NASHRecruiting
Est. primary completion 2027-09-03 · NCT03884075 · CT.gov ↗
What to watch
Phase 1ObesityNot yet recruiting
Est. primary completion 2027-09-11 · NCT07845578 · CT.gov ↗
What to watch
Early phase / not applicableType 2 DiabetesRecruiting
Est. primary completion 2027-09-30 · NCT06497595 · CT.gov ↗
What to watch
October 2027 (4)
Phase 2ObesityActive not recruiting
Est. primary completion 2027-10 · NCT07446998 · CT.gov ↗
What to watch
Phase 3Diabetes Mellitus, Type 1Recruiting
Est. primary completion 2027-10-01 · NCT05819138 · CT.gov ↗
What to watch
Phase 2Kidney Transplant RecipientsRecruiting
Est. primary completion 2027-10-01 · NCT05938712 · CT.gov ↗
What to watch
Phase 4Prostate CancerActive not recruiting
Est. primary completion 2027-10-31 · NCT06908694 · CT.gov ↗
What to watch
November 2027 (1)
Phase 3Type 2 DiabetesActive not recruiting
Est. primary completion 2027-11-07 · NCT03811561 · CT.gov ↗
What to watch
December 2027 (9)
Phase 4Hyperglycemia, Renal Transplant Complication Primary Non-Function, DiabetesRecruiting
Est. primary completion 2027-12 · NCT05702931 · CT.gov ↗
What to watch
Phase 4ObesityActive not recruiting
Est. primary completion 2027-12 · NCT06814938 · CT.gov ↗
What to watch
Phase 2Alzheimer Disease, Mild Cognitive Impairment, Metabolic SyndromeRecruiting
Est. primary completion 2027-12-01 · NCT06072963 · CT.gov ↗
What to watch
Phase 4ObesityNot yet recruiting
Est. primary completion 2027-12-30 · NCT07783854 · CT.gov ↗
What to watch
Phase 2Alzheimer DiseaseNot yet recruiting
Est. primary completion 2027-12-31 · NCT07200622 · CT.gov ↗
What to watch
2028 (44)
January 2028 (3)
Early phase / not applicableType 2 DiabetesRecruiting
Est. primary completion 2028-01-23 · NCT07779343 · CT.gov ↗
What to watch
Phase 4ObesityActive not recruiting
Est. primary completion 2028-01-31 · NCT06801015 · CT.gov ↗
What to watch
Phase 2Type 1 Diabetes MellitusNot yet recruiting
Est. primary completion 2028-01-31 · NCT07614412 · CT.gov ↗
What to watch
February 2028 (6)
Phase 3Acute Ischemic Stroke, Large Vessel Occlusion, Neuroprotective Drugs, Endovascular TreatmentNot yet recruiting
Est. primary completion 2028-02 · NCT06788626 · CT.gov ↗
What to watch
Early phase / not applicableObesityNot yet recruiting
Est. primary completion 2028-02 · NCT07621640 · CT.gov ↗
What to watch
Early phase / not applicableObesityRecruiting
Est. primary completion 2028-02-29 · NCT07732426 · CT.gov ↗
What to watch
April 2028 (4)
Phase 2Prostate Carcinoma, Recurrent Prostate CarcinomaRecruiting
Est. primary completion 2028-04-09 · NCT07202247 · CT.gov ↗
What to watch
Phase 2Cannabis Use Disorder, Cannabis Use Disorders, Cannabis Abuse, Cannabis Dependence, Cannabis AddictionRecruiting
Est. primary completion 2028-04-30 · NCT07523633 · CT.gov ↗
What to watch
May 2028 (7)
Phase 1/2Type 2 DiabetesRecruiting
Est. primary completion 2028-05 · NCT07563699 · CT.gov ↗
What to watch
Phase 1Prostate CancerNot yet recruiting
Est. primary completion 2028-05 · NCT07727473 · CT.gov ↗
What to watch
Early phase / not applicableObesityRecruiting
Est. primary completion 2028-05-01 · NCT07633639 · CT.gov ↗
What to watch
Phase 4Tobacco UseRecruiting
Est. primary completion 2028-05-30 · NCT06986993 · CT.gov ↗
What to watch
Phase 2Weight GainRecruiting
Est. primary completion 2028-05-31 · NCT07325500 · CT.gov ↗
What to watch
June 2028 (4)
Phase 3ObesityNot yet recruiting
Est. primary completion 2028-06 · NCT06909006 · CT.gov ↗
What to watch
Phase 4Chronic Kidney DiseaseRecruiting
Est. primary completion 2028-06 · NCT07239570 · CT.gov ↗
What to watch
Phase 2Intracerebral HemorrhageNot yet recruiting
Est. primary completion 2028-06-14 · NCT07613437 · CT.gov ↗
What to watch
Phase 1Pancreatic Cancer, Colorectal Cancer, Hepatocellular CarcinomaRecruiting
Est. primary completion 2028-06-30 · NCT07627191 · CT.gov ↗
What to watch
July 2028 (2)
August 2028 (4)
Phase 3Double DiabetesRecruiting
Est. primary completion 2028-08 · NCT05305794 · CT.gov ↗
What to watch
Phase 4Primary Open Angle Glaucoma (POAG), Open-Angle Glaucoma, GlaucomaRecruiting
Est. primary completion 2028-08 · NCT06792422 · CT.gov ↗
What to watch
Early phase / not applicableObesityRecruiting
Est. primary completion 2028-08-01 · NCT07091500 · CT.gov ↗
What to watch
Phase 4Type 2 DiabetesActive not recruiting
Est. primary completion 2028-08-17 · NCT05441267 · CT.gov ↗
What to watch
September 2028 (6)
Phase 4Atherosclerotic Cardiovascular DiseaseNot yet recruiting
Est. primary completion 2028-09 · NCT07617155 · CT.gov ↗
What to watch
Phase 4Type 2 DiabetesRecruiting
Est. primary completion 2028-09-01 · NCT06706284 · CT.gov ↗
What to watch
Phase 4ObesityNot yet recruiting
Est. primary completion 2028-09-01 · NCT07770152 · CT.gov ↗
What to watch
Phase 1Type 2 DiabetesNot yet recruiting
Est. primary completion 2028-09-06 · NCT07855133 · CT.gov ↗
What to watch
Early phase / not applicableObesityRecruiting
Est. primary completion 2028-09-30 · NCT07589322 · CT.gov ↗
What to watch
October 2028 (1)
Phase 2Ischemic StrokeNot yet recruiting
Est. primary completion 2028-10-31 · NCT07511543 · CT.gov ↗
What to watch
November 2028 (2)
December 2028 (5)
Phase 3Type 2 DiabetesRecruiting
Est. primary completion 2028-12 · NCT07581145 · CT.gov ↗
What to watch
Phase 4ObesityNot yet recruiting
Est. primary completion 2028-12-01 · NCT07592546 · CT.gov ↗
What to watch
Early phase / not applicableChronic Kidney DiseaseNot yet recruiting
Est. primary completion 2028-12-31 · NCT07391267 · CT.gov ↗
What to watch
Phase 2ObesityNot yet recruiting
Est. primary completion 2028-12-31 · NCT07820358 · CT.gov ↗
What to watch
2029 (13)
January 2029 (1)
Phase 2Cocaine Use DisorderRecruiting
Est. primary completion 2029-01-28 · NCT07227948 · CT.gov ↗
What to watch
March 2029 (2)
April 2029 (2)
May 2029 (1)
Phase 4Type 2 DiabetesNot yet recruiting
Est. primary completion 2029-05-01 · NCT07485062 · CT.gov ↗
What to watch
June 2029 (3)
Phase 1/2Alzheimer Dementia (AD)Recruiting
Est. primary completion 2029-06 · NCT07651319 · CT.gov ↗
What to watch
Phase 2Stage 1 Diabetes Mellitus, Type 1Not yet recruiting
Est. primary completion 2029-06-01 · NCT07430332 · CT.gov ↗
What to watch
Phase 2/3Kidney Transplant RecipientNot yet recruiting
Est. primary completion 2029-06-30 · NCT06913023 · CT.gov ↗
What to watch
July 2029 (1)
Phase 3Cardiovascular Diseases, Heart Failure, Type 1 Diabetes, Kidney FailureRecruiting
Est. primary completion 2029-07-01 · NCT06082063 · CT.gov ↗
What to watch
August 2029 (2)
October 2029 (1)
Phase 2HIV, Alcohol, Smoking Cigarette, Cardiovascular Disease PreventionRecruiting
Est. primary completion 2029-10-31 · NCT07221214 · CT.gov ↗
What to watch
2030 (10)
February 2030 (1)
Phase 2Methamphetamine-dependenceRecruiting
Est. primary completion 2030-02-15 · NCT07204249 · CT.gov ↗
What to watch
March 2030 (2)
May 2030 (1)
Early phase / not applicableMild Autonomous Cortisol Secretion (MACS), Autonomous Cortisol Secretion (ACS), Subclinical Cushing's, Mild Autonomous Cortisol ExcessRecruiting
Est. primary completion 2030-05-31 · NCT07361874 · CT.gov ↗
What to watch
July 2030 (2)
Early phase / not applicableSevere Mental Illness, Depression / Major Depressive Disorder, Bipolar Disorder (BD), SchizophreniaNot yet recruiting
Est. primary completion 2030-07 · NCT07586150 · CT.gov ↗
What to watch
Phase 3Schizophrenia Disorder, Metabolic Syndrome, Antipsychotic-induced Weight Gain, Cardiovascular Risk, Insulin ResistanceNot yet recruiting
Est. primary completion 2030-07-30 · NCT07770282 · CT.gov ↗
What to watch
September 2030 (3)
Phase 1/2Duchenne Muscular Dystrophy (DMD)Not yet recruiting
Est. primary completion 2030-09 · NCT07642635 · CT.gov ↗
What to watch
Phase 3Aortic Stenosis, Heart FailureNot yet recruiting
Est. primary completion 2030-09-01 · NCT07090343 · CT.gov ↗
What to watch
Phase 2Alzheimer Disease (AD)Not yet recruiting
Est. primary completion 2030-09-30 · NCT07135245 · CT.gov ↗
What to watch
November 2030 (1)
2031 (6)
January 2031 (2)
February 2031 (1)
Phase 3Craniopharyngioma, ChildNot yet recruiting
Est. primary completion 2031-02 · NCT07845994 · CT.gov ↗
What to watch
April 2031 (1)
Phase 3ObesityNot yet recruiting
Est. primary completion 2031-04-30 · NCT07021937 · CT.gov ↗
What to watch
July 2031 (1)
Phase 4Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8Not yet recruiting
Est. primary completion 2031-07-30 · NCT07769047 · CT.gov ↗
What to watch
October 2031 (1)
Phase 1ObesityNot yet recruiting
Est. primary completion 2031-10-31 · NCT07772960 · CT.gov ↗
What to watch
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.