Asset profile

semaglutide · Wegovy / Ozempic / Rybelsus

Peptide

Approvedregulatory verdict

Evidence outlook

Approved — Chronic Kidney Disease, Atherosclerotic Cardiovascular Disease, Type 2 Diabetes, MASH / NASH, Obesity

Regulatory approval supersedes design-level evidence grading — the trials behind approval are preserved below as the drug's evidence history.

How the evidence outlook works ↗

Featured trials

Research

Unlock featured-trial analysis

Research includes the instrumental studies, endpoints, key results, design grades, rationales and source links behind the Outlook.

Upcoming events

(45 total)

Estimated primary-completion dates from ClinicalTrials.gov — registry estimates, never confirmed readout dates; they can move as trials progress.

2026 (7)

August 2026 (1)

Phase 2Type 2 DiabetesActive not recruiting

Est. primary completion 2026-08-21 · NCT06797869 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

September 2026 (1)

Phase 2AsthmaActive not recruiting

Est. primary completion 2026-09 · NCT05254314 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

October 2026 (1)

Phase 2ObesityActive not recruiting

Est. primary completion 2026-10-15 · NCT07505303 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

November 2026 (1)

Phase 2ObesityActive not recruiting

Est. primary completion 2026-11-20 · NCT06577090 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

December 2026 (3)

Phase 2Type 2 DiabetesActive not recruiting

Est. primary completion 2026-12 · NCT05067621 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 2Type 2 DiabetesActive not recruiting

Est. primary completion 2026-12-31 · NCT06005012 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 2Chronic Kidney DiseaseRecruiting

Est. primary completion 2026-12-31 · NCT05173714 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

2027 (17)

March 2027 (2)

Phase 2ObesityRecruiting

Est. primary completion 2027-03 · NCT07101939 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 3ObesityActive not recruiting

Est. primary completion 2027-03-01 · NCT07011667 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

April 2027 (1)

Phase 2MASH / NASHActive not recruiting

Est. primary completion 2027-04-30 · NCT07466017 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

June 2027 (3)

Phase 2ObesityNot yet recruiting

Est. primary completion 2027-06 · NCT07411378 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 2Chronic Kidney DiseaseRecruiting

Est. primary completion 2027-06 · NCT05822609 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 2Alcohol Use Disorder (AUD), HIVRecruiting

Est. primary completion 2027-06-30 · NCT07040592 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

July 2027 (1)

Phase 2ObesityRecruiting

Est. primary completion 2027-07-12 · NCT07639021 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

September 2027 (2)

Phase 2MASH / NASHRecruiting

Est. primary completion 2027-09-03 · NCT03884075 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 2DiabetesRecruiting

Est. primary completion 2027-09-20 · NCT06762314 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

October 2027 (2)

Phase 2ObesityRecruiting

Est. primary completion 2027-10 · NCT07446998 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 2Kidney Transplant RecipientsRecruiting

Est. primary completion 2027-10-01 · NCT05938712 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

November 2027 (1)

Phase 3Type 2 DiabetesActive not recruiting

Est. primary completion 2027-11-07 · NCT03811561 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

December 2027 (5)

Phase 3ObesityRecruiting

Est. primary completion 2027-12 · NCT06499857 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 2Alzheimer Disease, Mild Cognitive Impairment, Metabolic SyndromeRecruiting

Est. primary completion 2027-12-01 · NCT06072963 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 1/2ObesityRecruiting

Est. primary completion 2027-12-28 · NCT05746039 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 2/3ObesityRecruiting

Est. primary completion 2027-12-30 · NCT06423599 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 2Alzheimer DiseaseNot yet recruiting

Est. primary completion 2027-12-31 · NCT07200622 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

2028 (8)

February 2028 (1)

Phase 3ObesityRecruiting

Est. primary completion 2028-02-01 · NCT05819853 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

April 2028 (1)

Phase 2ObesityRecruiting

Est. primary completion 2028-04-30 · NCT06411210 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

May 2028 (1)

Phase 2Weight GainRecruiting

Est. primary completion 2028-05-31 · NCT07325500 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

June 2028 (1)

Phase 3ObesityNot yet recruiting

Est. primary completion 2028-06 · NCT06909006 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

August 2028 (1)

Phase 3ObesityActive not recruiting

Est. primary completion 2028-08-28 · NCT06780449 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

September 2028 (1)

Phase 3ObesityRecruiting

Est. primary completion 2028-09 · NCT07294950 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

November 2028 (1)

Phase 3Type 2 DiabetesRecruiting

Est. primary completion 2028-11 · NCT07428746 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

December 2028 (1)

Phase 3Type 2 DiabetesRecruiting

Est. primary completion 2028-12 · NCT07581145 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

2029 (6)

April 2029 (1)

Phase 3MASH / NASHActive not recruiting

Est. primary completion 2029-04-25 · NCT04822181 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

June 2029 (2)

Phase 1/2Alzheimer Dementia (AD)Recruiting

Est. primary completion 2029-06 · NCT07651319 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 3Glucose Intolerance After a Recent History of Gestational DiabetesRecruiting

Est. primary completion 2029-06 · NCT05569772 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

July 2029 (1)

Phase 3Cardiovascular Diseases, Heart Failure, Type 1 Diabetes, Kidney FailureRecruiting

Est. primary completion 2029-07-01 · NCT06082063 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

September 2029 (1)

Phase 3Type 2 DiabetesNot yet recruiting

Est. primary completion 2029-09-07 · NCT07282613 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

October 2029 (1)

Phase 2HIV, Alcohol, Smoking Cigarette, Cardiovascular Disease PreventionRecruiting

Est. primary completion 2029-10-31 · NCT07221214 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

2030 (5)

March 2030 (1)

Phase 3ObesityRecruiting

Est. primary completion 2030-03-20 · NCT07253285 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

September 2030 (3)

Phase 1/2Duchenne Muscular Dystrophy (DMD)Not yet recruiting

Est. primary completion 2030-09 · NCT07642635 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 3Aortic Stenosis, Heart FailureNot yet recruiting

Est. primary completion 2030-09-01 · NCT07090343 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 2Alzheimer Disease (AD)Not yet recruiting

Est. primary completion 2030-09-30 · NCT07135245 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

November 2030 (1)

Phase 3ObesityNot yet recruiting

Est. primary completion 2030-11-01 · NCT06934655 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

2031 (2)

January 2031 (1)

Phase 2ObesityNot yet recruiting

Est. primary completion 2031-01-01 · NCT07731256 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

April 2031 (1)

Phase 3ObesityNot yet recruiting

Est. primary completion 2031-04-30 · NCT07021937 · CT.gov ↗

What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

See the full readout calendar ↗

All registered studies

Research

Unlock the complete ClinicalTrials.gov registry

Research includes every linked study, indication filters, phase grouping and featured-trial cross-links.

Competitive landscape

Research

Unlock the competitor landscape

Research compares assets by shared mechanism and indication, including each competitor's stage in the relevant market.