Asset profile
SAR441566
Small molecule
Evidence outlook · lead readout
SPECIFI-RA (NCT06073093) · Rheumatoid Arthritis
The lead readout missed its primary endpoint. The grade and rationale below record what the trial was designed to show and what it found.
SPECIFI-RA (NCT06073093): The study randomized 264 participants to four SAR441566 dose regimens or placebo and used triple masking of participants, investigators, and outcome assessors. Its primary endpoint was the clinical ACR20 response at week 12, but results have not been posted, so whether the endpoint was met or missed cannot be assessed.
Caveat: this result is taken from a company announcement or a news report of one, not from the trial registry or a peer-reviewed publication. Treat the figures as the sponsor's own statement, not as independently verified evidence.
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Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
76 competitors in this universe: 11 direct rivals (same mechanism and indication), 16 same-class, 49 same-indication; 52 further along in development.
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| SAR441566: this drug | Phase 2 | Small molecule | TNF-alpha | ||
| Adalimumab (Humira) | Approved | Monoclonal antibody | TNF-alpha | ||
| Adalimumab-Adbm (Cyltezo) | Approved | Monoclonal antibody | TNF-alpha | ||
| Adalimumab-Ryvk (Simlandi) | Approved | — | TNF-alpha | ||
| Certolizumab Pegol (Cimzia) | Approved | Antibody fragment | TNF-alpha | ||
| CT-P13 (Inflectra / Remsima) | Approved | Monoclonal antibody | TNF-alpha | ||
| Etanercept (Enbrel) | Approved | Protein / enzyme therapeutic | TNF-alpha, TNF-alpha / TNF-beta (lymphotoxin-alpha) | ||
| Golimumab (Simponi) | Approved | Monoclonal antibody | TNF-alpha | ||
| Infliximab (Remicade) | Approved | Monoclonal antibody | TNF-alpha | ||
| Infliximab-Qbtx (Ixifi) | Approved | Monoclonal antibody | TNF-alpha | ||
| PF-06410293 | Approved | Monoclonal antibody | TNF-alpha | ||
| CT-P17 | Phase 3 | Monoclonal antibody | TNF-alpha | ||
| Adalimumab-Aacf (Idacio) | Approved | — | TNF-alpha | ||
| Adalimumab-Aaty (Yuflyma) | Approved | — | TNF-alpha | ||
| Adalimumab-Adaz (Hyrimoz) | Approved | — | TNF-alpha | ||
| Adalimumab-Afzb (Abrilada) | Approved | — | TNF-alpha |
…and 61 more. Research shows the complete landscape.
Unlock the full comparison
Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
Compare head-to-head
5 further head-to-head pairs are tracked; the rosters on each shared mechanism and indication page list every rival in the race.
Upcoming events
(1 total)
Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.
2030 (1)
May 2030 (1)
What to watch
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.