Asset profile
DS-7011a
Unknown / undisclosed
Evidence outlook · no controlled comparison
NCT05638802 · Systemic Lupus Erythematosus
The lead study's design has limits that temper confidence (see the rationale below), and it produced no formal comparison against a control. This tier describes the design, not an outcome.
NCT05638802: The trial was randomized and double-blinded with a placebo arm, which are real methodological strengths, but the sample size was very small (19 drug vs 6 placebo) and unevenly split, and the pre-specified primary endpoint was safety (adverse event counts) rather than a disease-activity or clinical efficacy measure. Efficacy signals on skin and disease-activity scores were only secondary and descriptive, so this record does not demonstrate a statistically confirmed clinical benefit for DS-7011a.
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Featured trials
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Competitive landscape
54 competitors in this universe: 0 direct rivals (same mechanism and indication), 0 same-class, 54 same-indication; 29 further along in development.
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| DS-7011a: this drug | Phase 1/2 | — | Toll-like receptor 7 (TLR7) (inhibitor) | ||
| Anifrolumab | Approved | Monoclonal antibody | Type I interferon receptor, Type I interferon receptor subunit 1 (IFNAR1) | ||
| Avacopan (Tavneos) | Approved | Small molecule | Complement C5a receptor 1 (C5aR1/CD88) | ||
| Belimumab (GSK1550188) | Approved | Monoclonal antibody | BAFF / BLyS (B-lymphocyte stimulator), BAFF (BLyS) | ||
| Deucravacitinib (Sotyktu) | Approved | Small molecule | TYK2 | ||
| Repository Corticotropin (Acthar Gel) | Approved | Peptide | Melanocortin receptors (primarily MC2R on the adrenal cortex), Melanocortin 2 receptor (MC2R) (agonist) | ||
| Upadacitinib (Rinvoq) | Approved | Small molecule | JAK, JAK1 | ||
| Voclosporin (Lupkynis) | Approved | Small molecule | Calcineurin, Cyclophilin A (leading to calcineurin inhibition) | ||
| APG-2575(Lisaftoclax ) | Phase 3 | Small molecule | BCL-2 | ||
| AZD0120 | Phase 3 | Cell therapy | BCMA / CD19 | ||
| Blinatumomab | Phase 3 | Multispecific antibody | CD19 x CD3 | ||
| Descartes-08 | Phase 3 | Cell therapy | — | ||
| Divozilimab | Phase 3 | Monoclonal antibody | CD20 | ||
| Envudeucitinib | Phase 3 | Small molecule | TYK2 | ||
| Frexalimab | Phase 3 | Monoclonal antibody | CD40 ligand (CD40L / CD154) | ||
| Inebilizumab | Phase 3 | Monoclonal antibody | CD19 |
…and 39 more. Research shows the complete landscape.
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Upcoming events
No upcoming readouts on record for this asset.
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.