Asset profile
SYHX1901
Small molecule
Evidence outlook · registrational
Psoriasis: registrational readout pending
Entered Phase 3 on partial signal mid-stage evidence. Registrational readout expected around 2027-04-28.
NCT05858047: The trial randomized 93 participants to placebo or one of three SYHX1901 doses and masked participants, care providers, investigators, and outcome assessors. Its primary endpoint was the clinical PASI 75 response at week 12, but no results are available to determine whether the comparison was met.
How the evidence outlook works ↗
Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
70 competitors in this universe: 10 direct rivals (same mechanism and indication), 2 same-class, 58 same-indication; 26 further along in development.
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| SYHX1901: this drug | Phase 3 | Small molecule | TYK2 | ||
| Deucravacitinib (Sotyktu) | Approved | Small molecule | TYK2 | ||
| Envudeucitinib | Phase 3 | Small molecule | TYK2 | ||
| HS-10374 | Phase 3 | Small molecule | TYK2 | ||
| ICP-488 | Phase 3 | Small molecule | TYK2 | ||
| TQH3906 | Phase 3 | Small molecule | TYK2 | ||
| WD-890 | Phase 3 | Small molecule | TYK2 | ||
| Zasocitinib | Phase 3 | Small molecule | TYK2 | ||
| CMS-D001 | Phase 2/3 | Small molecule | TYK2 | ||
| BMS-986322 | Phase 2 | Small molecule | TYK2 | ||
| CS32582 | Phase 1/2 | Small molecule | TYK2 | ||
| D-2570 | Phase 3 | Small molecule | TYK2 | ||
| GLPG3667 | Phase 2 | Small molecule | TYK2 | ||
| Adalimumab (Humira) | Approved | Monoclonal antibody | TNF-alpha | ||
| Apremilast (Otezla) | Approved | Small molecule | PDE4 | ||
| Bimekizumab (Bimzelx) | Approved | Monoclonal antibody | IL-17A/F |
…and 55 more. Research shows the complete landscape.
Unlock the full comparison
Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
Compare head-to-head
4 further head-to-head pairs are tracked; the rosters on each shared mechanism and indication page list every rival in the race.
Upcoming events
(2 total)
Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.