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SHR-1701

Multispecific antibody

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Phase 3underway

Evidence outlook · registrational

Non-Small Cell Lung Cancer: registrational readout pending

Its supporting mid-stage evidence has not yet been graded on this platform. The registry's posted readout date (2024-12-30) has passed without a status update. Check News for topline announcements.

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Competitive landscape

60 competitors in this universe: 0 direct rivals (same mechanism and indication), 0 same-class, 60 same-indication; 58 further along in development.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
SHR-1701: this drugPhase 3Multispecific antibodyPD-L1 and TGF-beta (TGF-βRII trap)
Afatinib (Gilotrif)ApprovedSmall moleculeEGFR/HER1, HER2, HER4
Alectinib (Alecensa)ApprovedSmall moleculeALK
Alymsys (bevacizumab-Maly)ApprovedMonoclonal antibodyVEGF-A
AmivantamabApprovedMultispecific antibodyEGFR x c-MET
AtezolizumabApprovedMonoclonal antibodyPD-L1
BAT1706 (Avzivi)ApprovedMonoclonal antibodyVEGF-A
BAY2927088 (Hyrnuo)ApprovedSmall moleculeHER2 (ERBB2) exon 20 insertions and point mutations; also mutant-selective EGFR
BevacizumabApprovedMonoclonal antibodyVEGF-A, Vascular Endothelial Growth Factor Inhibitor
Bevacizumab-Awwb (MVASI)ApprovedMonoclonal antibodyVEGF-A
BinimetinibApprovedSmall moleculeMEK1/2
BrigatinibApprovedSmall moleculeALK
CapmatinibApprovedSmall moleculeMET
CemiplimabApprovedMonoclonal antibodyPD-1
CeritinibApprovedSmall moleculeALK
CrizotinibApprovedSmall moleculeALK, ROS1, MET/HGFR, and RON

…and 45 more. Research shows the complete landscape.

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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(18 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2027 (7)
July 2027 (2)
Phase 2Advanced Gastric Cancer, SHR1701Recruiting
Est. primary completion 2027-07-15 · NCT07294664 · CT.gov ↗
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Phase 1/2Non-Small Cell Lung CancerNot yet recruiting
Est. primary completion 2027-07-30 · NCT05503888 · CT.gov ↗
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September 2027 (2)
Phase 2Advanced Intrahepatic CholangiocarcinomaNot yet recruiting
Est. primary completion 2027-09-01 · NCT07147088 · CT.gov ↗
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Phase 2ESCCNot yet recruiting
Est. primary completion 2027-09-30 · NCT07524374 · CT.gov ↗
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December 2027 (3)
Phase 2Advanced Gastric Cancer, Metastatic Gastric Cancer, Gastroesophageal Junction AdenocarcinomaRecruiting
Est. primary completion 2027-12 · NCT07102901 · CT.gov ↗
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Phase 2HER2 Expression Gastric Cancer/Gastroesophageal Junction AdenocarcinomaRecruiting
Est. primary completion 2027-12 · NCT05671822 · CT.gov ↗
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Phase 2CRC (Colorectal Cancer)Recruiting
Est. primary completion 2027-12-31 · NCT07478731 · CT.gov ↗
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2028 (10)
January 2028 (1)
Phase 2Gastric Cancer (GC), Gastroesophageal Junction AdenocarcinomaRecruiting
Est. primary completion 2028-01-01 · NCT07311408 · CT.gov ↗
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March 2028 (1)
Phase 2Prostate Cancer, mCRPC (Metastatic Castration-resistant Prostate Cancer)Recruiting
Est. primary completion 2028-03-31 · NCT07451795 · CT.gov ↗
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April 2028 (1)
Phase 2Locally Advanced Colorectal CancerNot yet recruiting
Est. primary completion 2028-04 · NCT07503639 · CT.gov ↗
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May 2028 (1)
Phase 2Gastric AdenocarcinomaRecruiting
Est. primary completion 2028-05-31 · NCT07464756 · CT.gov ↗
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July 2028 (2)
Phase 2Non-Small Cell Lung CancerNot yet recruiting
Est. primary completion 2028-07 · NCT07619911 · CT.gov ↗
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Phase 2Gastric Cancer (GC), Gastroesophageal Junction AdenocarcinomaRecruiting
Est. primary completion 2028-07-30 · NCT07689851 · CT.gov ↗
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October 2028 (1)
Phase 2Non-Small Cell Lung CancerRecruiting
Est. primary completion 2028-10 · NCT07175220 · CT.gov ↗
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November 2028 (1)
Phase 2MelanomaNot yet recruiting
Est. primary completion 2028-11-30 · NCT07517653 · CT.gov ↗
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December 2028 (2)
Phase 2Ovarian CancerNot yet recruiting
Est. primary completion 2028-12-30 · NCT07355010 · CT.gov ↗
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Phase 2Gastric Adenocarcinoma and Gastroesophageal Junction AdenocarcinomaRecruiting
Est. primary completion 2028-12-30 · NCT07384234 · CT.gov ↗
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2029 (1)
August 2029 (1)
Phase 2Gastric Cancer, HER2 + Gastric Cancer, CLDN18.2-positive Adenocarcinoma of the Gastroesophageal Junction, PD-L1 PositiveNot yet recruiting
Est. primary completion 2029-08-01 · NCT06881017 · CT.gov ↗
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See the full readout calendar ↗

All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 3 (3)
Phase 2/3 (2)
Phase 2 (30)
Phase 1/2 (7)
Phase 1 (6)
Appears in other studies (3)