Asset profile
SER-100
Small molecule
Evidence outlook · program status
Discontinued, for reasons the sponsor has not stated
SER-100 is Serodus's peptide licensed from Zealand Pharma (ZP120, a nociceptin/orphanin FQ receptor partial agonist); the CT.gov record NCT00283361 confirms the Zealand origin. Serodus took it into a Phase 2 study in isolated systolic hypertension that completed in 2014. Serodus's own website today enumerates its whole pipeline as two candidates, SER150 and SER140, both in diabetic kidney disease, and states the company is exploring options for an acquisition of that pipeline; SER-100 is not on it. Absence from a live company's own current pipeline supports discontinued, but nothing dates or explains the stop. The trials below are preserved as the program's evidence history; no evidence signal is assigned to a program the sponsor has stopped.
Caveat: this result is taken from a company announcement or a news report of one, not from the trial registry or a peer-reviewed publication. Treat the figures as the sponsor's own statement, not as independently verified evidence.
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Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
60 competitors in this universe: 0 direct rivals (same mechanism and indication), 0 same-class, 60 same-indication; 35 further along in development.
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| SER-100: this drug | Phase 2 | Small molecule | ORL-1 (nociceptin opioid-like receptor) | ||
| Aprocitentan (Tryvio) | Approved | Small molecule | Endothelin receptor (ETA/ETB, dual) | ||
| Baxdrostat (Baxfendy) | Approved | Small molecule | Aldosterone synthase (CYP11B2) | ||
| Bosentan (Tracleer) | Approved | Small molecule | Endothelin receptor (ETA/ETB, dual) | ||
| Epoprostenol (Flolan) | Approved | Small molecule | IP receptor (prostacyclin pathway) | ||
| Nitric Oxide (INOmax) | Approved | Gas (inhaled) | Nitric oxide | ||
| Sacubitril / Valsartan (Entresto) | Approved | Small molecule | Neprilysin + Angiotensin II receptor (dual) | ||
| Treprostinil (Orenitram / Remodulin / Tyvaso) | Approved | Small molecule | IP receptor (prostacyclin pathway) | ||
| Treprostinil (Yutrepia, Liquidia) | Approved | Small molecule | IP receptor (prostacyclin pathway) | ||
| AD-209 | Phase 3 | Small molecule | Angiotensin II type 1 receptor / L-type calcium channel / Na-Cl cotransporter | ||
| AGSAVI | Phase 3 | Small molecule | Angiotensin II receptor / Calcium channel / Thiazide-like diuretic | ||
| AJU-C52 | Phase 3 | Small molecule | Angiotensin II receptor / Calcium channel / Thiazide-like diuretic | ||
| Ambrisentan (Letairis) | Phase 3 | Small molecule | Endothelin A receptor | ||
| C2402 | Phase 3 | Small molecule | — | ||
| CJ-30060 | Phase 3 | Small molecule | Angiotensin II receptor / Calcium channel / HMG-CoA reductase | ||
| CJ-30061 | Phase 3 | Small molecule | Angiotensin II receptor / Calcium channel / HMG-CoA reductase |
…and 45 more. Research shows the complete landscape.
Unlock the full comparison
Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
Upcoming events
No upcoming readouts on record for this asset.
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.