Asset profile
GK1-399 (formerly TTP399)
Small molecule
Evidence outlook · lead readout
NCT01474083 · Type 2 Diabetes Mellitus
The completed lead evidence is positive, with design limits that temper confidence — see the rationale below for exactly which.
NCT01474083: The study was randomized, quadruple-blind, and placebo-controlled, with 248 participants across three GK1-399 dose groups and a placebo group. Its primary endpoint was a pharmacokinetic measure, a surrogate rather than a clinical outcome, and no primary endpoint results are posted.
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