Asset profile
CC-223
Small molecule
Evidence outlook · program status
Discontinued (2015), as a strategic decision by the sponsor
CC-223 was Celgene's dual mTORC1/mTORC2 (TORK) inhibitor, taken into phase 1/2 in multiple myeloma, non-small cell lung cancer and other tumours. Celgene's FY2014 Form 10-K pipeline table still carried 'Dual TORK Inhibitor: CC-223 . Phase I 2012' under Solid Tumors; the FY2015 Form 10-K reprints the same Area-of-Research table for every franchise, including Multiple Myeloma and Solid Tumors, and CC-223 appears nowhere in the document, dating the stop to 2015. The molecule was later out-licensed to Antengene as ATG-008, whose hepatocellular study (NCT03591965) was itself terminated on a development-strategy change. The trials below are preserved as the program's evidence history; no evidence signal is assigned to a program the sponsor has stopped.
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Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
61 competitors in this universe: 0 direct rivals (same mechanism and indication), 1 same-class, 60 same-indication; 61 further along in development.
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| CC-223: this drug | Phase 1/2 | Small molecule | mTOR (inhibitor) | ||
| LAM-001 | Phase 2 | Small molecule | mTOR (inhibitor) | ||
| Afatinib (Gilotrif) | Approved | Small molecule | EGFR/HER1, HER2, HER4 | ||
| Alectinib (Alecensa) | Approved | Small molecule | ALK | ||
| Alymsys (bevacizumab-Maly) | Approved | Monoclonal antibody | VEGF-A | ||
| Amivantamab | Approved | Multispecific antibody | EGFR x c-MET | ||
| Atezolizumab | Approved | Monoclonal antibody | PD-L1 | ||
| BAT1706 (Avzivi) | Approved | Monoclonal antibody | VEGF-A | ||
| BAY2927088 (Hyrnuo) | Approved | Small molecule | HER2 (ERBB2) exon 20 insertions and point mutations; also mutant-selective EGFR | ||
| Bevacizumab | Approved | Monoclonal antibody | VEGF-A, Vascular Endothelial Growth Factor Inhibitor | ||
| Bevacizumab-Awwb (MVASI) | Approved | Monoclonal antibody | VEGF-A | ||
| Binimetinib | Approved | Small molecule | MEK1/2 | ||
| Brigatinib | Approved | Small molecule | ALK | ||
| Capmatinib | Approved | Small molecule | MET | ||
| Cemiplimab | Approved | Monoclonal antibody | PD-1 | ||
| Ceritinib | Approved | Small molecule | ALK |
…and 46 more. Research shows the complete landscape.
Unlock the full comparison
Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
Upcoming events
No upcoming readouts on record for this asset.
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.