Asset profile
AZD7503
Unknown / undisclosed
Evidence outlook · program status
Discontinued, as a strategic decision by the sponsor
AZD7503 was AstraZeneca's siRNA/antisense agent targeting HSD17B13 for MASH. The sponsor terminated its Phase 1 study in participants with hepatic impairment, giving the compound's discontinuation as the reason; no AZD7503 study has started since. The trials below are preserved as the program's evidence history; no evidence signal is assigned to a program the sponsor has stopped.
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Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
30 competitors in this universe: 1 direct rival (same mechanism and indication), 0 same-class, 29 same-indication; 26 further along in development.
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| AZD7503: this drug | Phase 1 | — | HSD17B13 (hydroxysteroid 17-beta dehydrogenase 13) mRNA | ||
| ARO-HSD | Phase 1/2 | — | HSD17B13 (hydroxysteroid 17-beta dehydrogenase 13) mRNA | ||
| Resmetirom (Rezdiffra) | Approved | Small molecule | Thyroid hormone receptor-beta | ||
| Rosuvastatin | Approved | Small molecule | HMG-CoA reductase | ||
| Semaglutide (Wegovy / Ozempic / Rybelsus) | Approved | Peptide | GLP-1 receptor | ||
| ALN-CIDEB | Phase 3 | RNA / oligonucleotide | CIDEB | ||
| Denifanstat | Phase 3 | Small molecule | Fatty acid synthase (FASN), FASN | ||
| Efimosfermin | Phase 3 | Protein / enzyme therapeutic | FGF21 | ||
| Efimosfermin Alfa | Phase 3 | Protein / enzyme therapeutic | FGF21 receptor | ||
| Lobeglitazone (Duvie) | Phase 3 | Small molecule | PPAR-gamma | ||
| Namodenoson | Phase 3 | — | Adenosine A3 receptor | ||
| Pemvidutide | Phase 3 | Peptide | GLP-1/glucagon receptor (dual) | ||
| Survodutide | Phase 3 | Peptide | GLP-1/glucagon receptor (dual) | ||
| Belapectin | Phase 2/3 | Protein / enzyme therapeutic | Galectin-3 | ||
| GR-MD-02 | Phase 2/3 | Protein / enzyme therapeutic | Galectin-3 | ||
| ALN-HSD | Phase 2 | RNA / oligonucleotide | HSD17B13 |
…and 15 more. Research shows the complete landscape.
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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
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Upcoming events
No upcoming readouts on record for this asset.
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.