Asset profile

ALN-PNP

Unknown / undisclosed

Partialsignal

Evidence outlook · lead readout

NCT06024408 · Nonalcoholic Fatty Liver Disease (NAFLD), Nonalcoholic Steatohepatitis (NASH), Genetic Risk Factor

The completed lead evidence is positive, with design limits that temper confidence — see the rationale below for exactly which.

NCT06024408: Participants were randomly assigned and neither they nor the study staff knew who received ALN-PNP versus placebo, which is a solid design. But only 9 people were enrolled and the trial's own findings have not yet been posted, so there is no result to judge yet.

How the evidence outlook works ↗

Upcoming events

(2 total)

Estimated primary-completion dates from ClinicalTrials.gov — registry estimates, never confirmed readout dates; they can move as trials progress.

2027 (1)
August 2027 (1)
Phase 1/2MASH / NASHRecruiting
Est. primary completion 2027-08-10 · NCT05648214 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

2030 (1)
March 2030 (1)
Phase 2MASH / NASHRecruiting
Est. primary completion 2030-03-15 · NCT07527910 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

See the full readout calendar ↗

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